TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 431.325 | Formula: C16H12F7NO3S
H donors: 1 H acceptors: 3 LogP: 3.93 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Fc1cccc(c1)S(=O)(=O)N(c1ccc(cc1)C(C(F)(F)F)(C(F)(F)F)O)C
InChi: 1S/C16H12F7NO3S/c1-24(28(26,27)13-4-2-3-11(17)9-13)12-7-5-10(6-8-12)14(25,15(18,19)20)16(21,22)23/h2-9,25H,1H3
InChiKey: GMXMRZHYIVKFOF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	cathepsin L-like protease	0.0053	0.062	0.0579
Trypanosoma cruzi	cysteine peptidase, putative	0.0053	0.062	0.0579
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0045	0.0372	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0053	0.062	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0098	0.2091	0.2134
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.062	0.0626
Schistosoma mansoni	histone deacetylase 4 5	0.0336	0.9797	0.9796
Leishmania major	cathepsin L-like protease	0.0053	0.062	0.0579
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0313	0.9069	1
Onchocerca volvulus		0.0053	0.062	0.1503
Leishmania major	oligopeptidase b	0.0051	0.0553	0.051
Trichomonas vaginalis	histone deacetylase, putative	0.0313	0.9069	1
Schistosoma mansoni	histone deacetylase	0.0313	0.9069	0.9064
Echinococcus multilocularis	cathepsin b	0.0282	0.8064	0.8054
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0238	0.0243
Echinococcus multilocularis	prolyl endopeptidase	0.0128	0.3046	0.3006
Schistosoma mansoni	hypothetical protein	0.0048	0.0457	0.0403
Loa Loa (eye worm)	histone deacetylase 1	0.0313	0.9069	0.9257
Echinococcus multilocularis	adam	0.0045	0.0379	0.0324
Loa Loa (eye worm)	histone deacetylase 7A	0.0336	0.9797	1
Trypanosoma cruzi	histone deacetylase, putative	0.0098	0.2091	0.2089
Brugia malayi	Cathepsin L-like precursor	0.0053	0.062	0.0633
Onchocerca volvulus		0.0053	0.062	0.1503
Echinococcus granulosus	aminopeptidase N	0.012	0.2812	0.2771
Echinococcus granulosus	cathepsin l1	0.0053	0.062	0.0568
Brugia malayi	Trypsin family protein	0.0094	0.1947	0.1988
Plasmodium vivax	histone deacetylase, putative	0.0098	0.2091	0.1602
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0128	0.3046	0.3006
Onchocerca volvulus		0.0053	0.062	0.1503
Brugia malayi	Cathepsin L-like precursor	0.0053	0.062	0.0633
Entamoeba histolytica	cysteine proteinase, putative	0.0053	0.062	0.0626
Loa Loa (eye worm)	histone deacetylase 3	0.0313	0.9069	0.9257
Echinococcus granulosus	prolyl endopeptidase	0.0128	0.3046	0.3006
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0142	0.0145
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0313	0.9069	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0038	0.0142	0.0095
Plasmodium falciparum	histone deacetylase 1	0.0313	0.9069	0.9207
Echinococcus multilocularis	cathepsin L cysteine protease	0.0053	0.062	0.0568
Onchocerca volvulus		0.0053	0.062	0.1503
Loa Loa (eye worm)	fibroinase	0.0053	0.062	0.0633
Toxoplasma gondii	prolyl endopeptidase	0.0128	0.3046	0.2643
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0379	0.0387
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0099	0.2108	0.2106
Trypanosoma brucei	histone deacetylase, putative	0.0336	0.9797	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0053	0.062	0.0568
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0051	0.0553	0.051
Leishmania major	cathepsin L-like protease	0.0053	0.062	0.0579
Onchocerca volvulus		0.0035	0.0056	0.0136
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.062	0.0626
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.062	0.0626
Toxoplasma gondii	histone deacetylase HDAC5	0.0098	0.2091	0.1602
Trypanosoma brucei	histone deacetylase 3	0.0336	0.9797	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0099	0.2108	0.2106
Trypanosoma cruzi	histone deacetylase, putative	0.0336	0.9797	1
Toxoplasma gondii	histone deacetylase HDAC2	0.0313	0.9069	0.9207
Brugia malayi	prolyl oligopeptidase family protein	0.0128	0.3046	0.3109
Echinococcus multilocularis	histone deacetylase 6	0.0336	0.9797	0.9796
Echinococcus granulosus	cathepsin l1	0.0038	0.0142	0.0086
Giardia lamblia	Histone deacetylase	0.0313	0.9069	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0053	0.062	0.0568
Echinococcus granulosus	histone deacetylase 8	0.0098	0.2091	0.2046
Echinococcus granulosus	histone deacetylase 7	0.0336	0.9797	0.9796
Echinococcus granulosus	histone deacetylase	0.0336	0.9797	0.9796
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.062	0.0626
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0044	0.0327	0.0272
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.062	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0308	0.0315
Leishmania major	cathepsin L-like protease	0.0053	0.062	0.0579
Echinococcus multilocularis	histone deacetylase 6	0.0336	0.9797	0.9796
Plasmodium vivax	histone deacetylase 1, putative	0.0313	0.9069	0.9207
Leishmania major	histone deacetylase, putative	0.0313	0.9069	0.9253
Schistosoma mansoni	histone deacetylase hda2	0.0098	0.2091	0.2046
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0128	0.3046	0.3006
Trypanosoma cruzi	histone deacetylase, putative	0.0336	0.9797	1
Echinococcus multilocularis	histone deacetylase	0.0336	0.9797	0.9796
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0045	0.0372	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1947	0.1988
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0038	0.0142	0.0095
Brugia malayi	cathepsin B-like cysteine proteinase	0.0282	0.8064	0.8232
Leishmania major	cysteine peptidase A (CPA)	0.0053	0.062	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0128	0.3046	0.3109
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.062	0.0579
Leishmania major	cathepsin L-like protease	0.0053	0.062	0.0579
Schistosoma mansoni	cathepsin F (C01 family)	0.0053	0.062	0.0568
Brugia malayi	Cathepsin L-like precursor	0.0053	0.062	0.0633
Brugia malayi	Cathepsin L-like precursor	0.0038	0.0142	0.0145
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0053	0.062	0.0568
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0053	0.062	0.0568
Loa Loa (eye worm)	histone deacetylase 11	0.0098	0.2091	0.2134
Brugia malayi	hypothetical protein	0.0035	0.0056	0.0057
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.062	0.0579
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.062	0.0626
Trypanosoma cruzi	histone deacetylase, putative	0.0098	0.2091	0.2089
Loa Loa (eye worm)	hypothetical protein	0.0161	0.4127	0.4213
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0094	0.1947	0.1902
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0051	0.0553	1
Onchocerca volvulus	Cathepsin L homolog	0.0053	0.062	0.1503
Brugia malayi	Histone deacetylase family protein	0.0336	0.9797	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.062	0.0579
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0038	0.0142	0.0145
Trypanosoma cruzi	cysteine peptidase, putative	0.0053	0.062	0.0579
Schistosoma mansoni	adam (A disintegrin and metalloprotease	0.0045	0.0379	0.0324
Trichomonas vaginalis	histone deacetylase, putative	0.0313	0.9069	1
Entamoeba histolytica	cysteine proteinase, putative	0.0038	0.0142	0.0095
Trichomonas vaginalis	histone deacetylase, putative	0.0313	0.9069	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.062	0.0579
Echinococcus multilocularis	histone deacetylase 8	0.0098	0.2091	0.2046
Echinococcus granulosus	cathepsin b	0.0282	0.8064	0.8054
Brugia malayi	Cathepsin L-like precursor	0.0053	0.062	0.0633
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0099	0.2108	0.2106
Brugia malayi	ADAM-TS Spacer 1 family protein	0.0045	0.0379	0.0387
Trypanosoma cruzi	cysteine peptidase, putative	0.0053	0.062	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0142	0.0145
Trypanosoma cruzi	cruzipain precursor, putative	0.0053	0.062	0.0579
Loa Loa (eye worm)	calpain family protein 1	0.0043	0.0308	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0379	0.0387
Echinococcus multilocularis	histone deacetylase 1	0.0313	0.9069	0.9064
Loa Loa (eye worm)	hypothetical protein	0.0108	0.2407	0.2457
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.062	0.0579
Echinococcus granulosus	histone deacetylase 6	0.0336	0.9797	0.9796
Trypanosoma cruzi	prolyl endopeptidase	0.0128	0.3046	0.3069
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0053	0.062	0.0626
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.062	0.0579
Onchocerca volvulus		0.0038	0.0142	0.0344
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.062	0.0626
Trypanosoma cruzi	oligopeptidase b	0.0051	0.0553	0.051
Trypanosoma cruzi	cysteine peptidase, putative	0.0053	0.062	0.0579
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.062	0.0626
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0097	0.2066	0.2109
Loa Loa (eye worm)	hypothetical protein	0.0085	0.1662	0.1697
Brugia malayi	Cathepsin L-like precursor	0.0053	0.062	0.0633
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.004	0.0205	0.015
Trypanosoma cruzi	histone deacetylase 1, putative	0.0313	0.9069	0.9253
Schistosoma mansoni	histone deacetylase 1 2 3	0.0098	0.2091	0.2046
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0099	0.2108	0.2063
Loa Loa (eye worm)	hypothetical protein	0.0282	0.8064	0.8232
Trichomonas vaginalis	histone deacetylase, putative	0.0313	0.9069	1
Plasmodium vivax	histone deacetylase 2, putative	0.0336	0.9797	1
Brugia malayi	histone deacetylase 3 (HD3)	0.0313	0.9069	0.9257
Toxoplasma gondii	histone deacetylase HDAC4	0.0098	0.2091	0.1602
Trypanosoma brucei	histone deacetylase 2	0.0098	0.2091	0.2089
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.062	0.0626
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.0114	0.2611	1
Echinococcus multilocularis	calpain A	0.0045	0.0372	0.0317
Echinococcus granulosus	allatostatin A receptor	0.0161	0.4127	0.4094
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0051	0.0553	0.1324
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0282	0.8064	0.8054
Echinococcus granulosus	calpain A	0.0045	0.0372	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0142	0.0145
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.062	0.0626
Schistosoma mansoni	histone deacetylase	0.0313	0.9069	0.9064
Loa Loa (eye worm)	ctsf protein	0.0053	0.062	0.0633
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0038	0.0142	0.0088
Schistosoma mansoni	cathepsin F (C01 family)	0.0053	0.062	0.0568
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0128	0.3046	0.7379
Toxoplasma gondii	histone deacetylase HDAC3	0.0313	0.9069	0.9207
Echinococcus multilocularis	histone deacetylase 3	0.0313	0.9069	0.9064
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0041	0.0238	0.0243
Entamoeba histolytica	cysteine proteinase, putative	0.0053	0.062	0.0626
Trichomonas vaginalis	histone deacetylase, putative	0.0313	0.9069	1
Trypanosoma cruzi	histone deacetylase 1, putative	0.0313	0.9069	0.9253
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0282	0.8064	0.8222
Brugia malayi	Peptidase family M1 containing protein	0.012	0.2812	0.287
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.062	0.0626
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0282	0.8064	0.8054
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0149	0.0152
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0192	0.514	0.5112
Loa Loa (eye worm)	hypothetical protein	0.0103	0.2258	0.2305
Schistosoma mansoni	histone deacetylase 4 5	0.0336	0.9797	0.9796
Leishmania major	cathepsin L-like protease	0.0053	0.062	0.0579
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.062	0.0626
Leishmania major	cathepsin L-like protease	0.0053	0.062	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1947	0.1988
Brugia malayi	Cathepsin L-like precursor	0.0053	0.062	0.0633
Loa Loa (eye worm)	histone deacetylase	0.0336	0.9797	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.062	0.0626
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0161	0.4127	0.4094
Entamoeba histolytica	histone deacetylase, putative	0.0313	0.9069	1
Echinococcus multilocularis	histone deacetylase 6	0.0342	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.062	0.0626
Schistosoma mansoni	histone deacetylase hda2	0.0342	1	1
Onchocerca volvulus	Matrilysin homolog	0.0144	0.359	0.8697
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0192	0.514	0.5112
Onchocerca volvulus		0.0053	0.062	0.1503
Loa Loa (eye worm)	cysteine protease	0.0053	0.062	0.0633
Brugia malayi	ADAMTS-like protease	0.0045	0.0379	0.0387
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0045	0.0372	0.0317
Brugia malayi	cathepsin L-like precursor	0.0038	0.0142	0.0145
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.062	0.0579
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0053	0.062	0.0626
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0094	0.1947	0.1902
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.062	0.0626
Loa Loa (eye worm)	aminopeptidase N	0.0035	0.0056	0.0057
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.062	0.0579
Brugia malayi	calpain family protein 1	0.0043	0.0308	0.0315
Leishmania major	cathepsin L-like protease	0.0053	0.062	0.0579
Plasmodium vivax	histone deacetylase, putative	0.0336	0.9797	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.062	0.0626
Onchocerca volvulus		0.0094	0.1947	0.4717
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0282	0.8064	0.8054
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0045	0.0372	0.0317
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.062	0.0626
Brugia malayi	histone deacetylase 11	0.0098	0.2091	0.2134
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.062	0.0626
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0103	0.2258	0.2214
Brugia malayi	Matrixin family protein	0.0151	0.3808	0.3887
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0053	0.062	0.0633
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0128	0.3046	0.3069
Trypanosoma cruzi	oligopeptidase b	0.0051	0.0553	0.051
Echinococcus granulosus	histone deacetylase 3	0.0313	0.9069	0.9064
Mycobacterium ulcerans	hydrolase	0.0041	0.0238	0.3669
Leishmania major	histone deacetylase, putative	0.0313	0.9069	0.9253
Plasmodium falciparum	histone deacetylase, putative	0.0336	0.9797	1
Brugia malayi	Cathepsin L-like precursor	0.0038	0.0142	0.0145
Brugia malayi	Histone deacetylase 1	0.0313	0.9069	0.9257
Brugia malayi	histone deacetylase 1 (HD1)	0.0313	0.9069	0.9257
Trypanosoma brucei	histone deacetylase 4	0.0336	0.9797	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.062	0.0626
Loa Loa (eye worm)	matrixin family protein	0.0151	0.3808	0.3887
Onchocerca volvulus		0.0053	0.062	0.1503
Trypanosoma brucei	prolyl endopeptidase	0.0128	0.3046	0.3069
Toxoplasma gondii	histone deacetylase HDAC1	0.0336	0.9797	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0053	0.062	0.0633
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0313	0.9069	1
Brugia malayi	calpain family protein 1	0.0043	0.0308	0.0315
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.062	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0237	0.6613	0.675
Toxoplasma gondii	cathepsin B	0.0099	0.2108	0.1621
Schistosoma mansoni	cathepsin F (C01 family)	0.0038	0.0142	0.0086
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0075	0.1332	0.3226
Onchocerca volvulus		0.0048	0.0457	0.1107
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0282	0.8064	0.8054
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0051	0.0553	0.051
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0051	0.0553	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0053	0.062	0.0568
Loa Loa (eye worm)	cathepsin B	0.0099	0.2108	0.2151
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.062	0.0579
Trichomonas vaginalis	histone deacetylase, putative	0.0313	0.9069	1
Echinococcus multilocularis	allatostatin A receptor	0.0161	0.4127	0.4094
Brugia malayi	angiogenesis inhibito	0.0045	0.0379	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0244	0.6816	0.6957
Trypanosoma cruzi	histone deacetylase, putative	0.0336	0.9797	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.062	0.0626
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0051	0.0553	0.051
Entamoeba histolytica	cysteine protease, putative	0.0053	0.062	0.0626
Mycobacterium tuberculosis	Probable peptidase	0.0051	0.0553	0.1324
Onchocerca volvulus	Cathepsin L homolog	0.0053	0.062	0.1503
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0043	0.0308	0.0254
Echinococcus multilocularis	cathepsin b	0.0282	0.8064	0.8054
Leishmania major	histone deacetylase, putative	0.0336	0.9797	1
Onchocerca volvulus		0.0161	0.4127	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0099	0.2108	0.2276
Trypanosoma brucei	histone deacetylase 1	0.0313	0.9069	0.9253
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.062	0.0626
Onchocerca volvulus		0.012	0.2812	0.6812
Onchocerca volvulus	Cathepsin F homolog	0.0053	0.062	0.1503
Plasmodium falciparum	histone deacetylase 2	0.0336	0.9797	1
Trypanosoma brucei	oligopeptidase b	0.0051	0.0553	0.051
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.062	0.0579
Echinococcus granulosus	histone deacetylase 6	0.0336	0.9797	0.9796
Echinococcus granulosus	histone deacetylase 1	0.0313	0.9069	0.9064
Onchocerca volvulus		0.0085	0.1677	0.4062
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.062	0.0626
Onchocerca volvulus		0.0053	0.062	0.1503
Echinococcus granulosus	adam	0.0045	0.0379	0.0324
Echinococcus granulosus	cathepsin b	0.0282	0.8064	0.8054
Echinococcus multilocularis	histone deacetylase 7	0.0336	0.9797	0.9796
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0051	0.0553	0.051
Onchocerca volvulus	Histone deacetylase 10 homolog	0.0098	0.2091	0.5065
Brugia malayi	Histone deacetylase family protein	0.0336	0.9797	1
Echinococcus multilocularis	cysteine protease	0.0053	0.062	0.0568
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0051	0.0553	0.051
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.062	0.0579
Brugia malayi	Papain family cysteine protease containing protein	0.0053	0.062	0.0633
Brugia malayi	hypothetical protein	0.0045	0.0379	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0313	0.9069	0.9257
Brugia malayi	Hemopexin family protein	0.0048	0.0457	0.0466
Brugia malayi	Peptidase family M1 containing protein	0.0035	0.0056	0.0057
Echinococcus multilocularis	cysteine protease	0.0053	0.062	0.0568
Loa Loa (eye worm)	matrixin family protein	0.0075	0.1332	0.1359
Leishmania major	histone deacetylase, putative	0.0336	0.9797	1
Echinococcus multilocularis	aminopeptidase N	0.012	0.2812	0.2771

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3322058

Bibliographic References

No literature references available for this target.

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Detailed information for compound 924428