Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.002 | 0.0018 | 0.0018 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0079 | 0.0657 | 0.0657 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0061 | 0.0061 |
Brugia malayi | hypothetical protein | 0.003 | 0.013 | 0.013 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0296 | 0.0296 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.013 | 0.013 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.002 | 0.0018 | 0.0018 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0296 | 0.0296 |
Brugia malayi | cAMP-dependent protein kinase catalytic subunit, putative | 0.0039 | 0.0225 | 0.0225 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0039 | 0.0225 | 0.0165 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0947 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0057 | 0.0416 | 0.0416 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.0265 | 0.0041 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0039 | 0.0225 | 0.0225 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0061 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0071 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.003 | 0.013 | 0.013 |
Echinococcus multilocularis | atrial natriuretic peptide receptor | 0.003 | 0.013 | 0.013 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.003 | 0.013 | 0.013 |
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0039 | 0.0225 | 0.0225 |
Echinococcus granulosus | rho-associated protein kinase 1 | 0.0142 | 0.1326 | 0.1326 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0197 | 0.0197 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0043 | 0.0265 | 0.0265 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0197 | 0.0197 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0947 | 1 | 1 |
Brugia malayi | PHD-finger family protein | 0.0057 | 0.0416 | 0.0416 |
Echinococcus multilocularis | receptor type guanylyl cyclase | 0.003 | 0.013 | 0.013 |
Schistosoma mansoni | hypothetical protein | 0.0417 | 0.4293 | 0.4293 |
Giardia lamblia | PHD finger protein 15 | 0.0057 | 0.0416 | 0.0196 |
Loa Loa (eye worm) | metabotropic glutamate receptor 8 | 0.003 | 0.013 | 0.013 |
Schistosoma mansoni | glutamate receptor NMDA | 0.003 | 0.013 | 0.013 |
Onchocerca volvulus | Atrial natriuretic peptide receptor 3 homolog | 0.003 | 0.013 | 0.0541 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0271 | 0.2724 | 0.2724 |
Brugia malayi | jmjC domain containing protein | 0.0187 | 0.1815 | 0.1815 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0947 | 1 | 1 |
Toxoplasma gondii | AGC kinase | 0.0039 | 0.0225 | 0.0225 |
Trypanosoma brucei | cAMP-dependent protein kinase catalytic subunit 1 | 0.0039 | 0.0225 | 0.0225 |
Onchocerca volvulus | Alhambra homolog | 0.0057 | 0.0416 | 0.2809 |
Plasmodium falciparum | phd finger protein, putative | 0.0057 | 0.0416 | 0.0416 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.01 | 0.0883 | 0.0883 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0053 | 0.0368 | 0.0368 |
Plasmodium falciparum | conserved Plasmodium membrane protein, unknown function | 0.002 | 0.0022 | 0.0022 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0135 | 0.0135 |
Onchocerca volvulus | 0.0142 | 0.1326 | 1 | |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.003 | 0.013 | 0.013 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0296 | 0.0296 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0083 | 0.0696 | 0.0696 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.013 | 0.0069 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0057 | 0.0416 | 0.0416 |
Echinococcus multilocularis | 0.0947 | 1 | 1 | |
Mycobacterium ulcerans | hypothetical protein | 0.0414 | 0.4254 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0265 | 0.0265 |
Loa Loa (eye worm) | AGC/PKA protein kinase | 0.0039 | 0.0225 | 0.0225 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.1657 | 0.1657 |
Brugia malayi | CHE-14 protein | 0.0043 | 0.0265 | 0.0265 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0142 | 0.1326 | 0.1326 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0039 | 0.0225 | 0.0225 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.0947 | 1 | 1 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0417 | 0.4293 | 0.4293 |
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0039 | 0.0225 | 0.0225 |
Echinococcus multilocularis | expressed conserved protein | 0.0094 | 0.0817 | 0.0817 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0039 | 0.0225 | 0.0225 |
Trypanosoma brucei | cAMP-dependent protein kinase catalytic subunit 2 | 0.0039 | 0.0225 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.013 | 0.013 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.003 | 0.013 | 0.013 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0947 | 1 | 1 |
Plasmodium falciparum | cAMP-dependent protein kinase catalytic subunit | 0.0039 | 0.0225 | 0.0225 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0947 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.037 | 0.037 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0197 | 0.0136 |
Leishmania major | protein kinase A catalytic subunit | 0.0039 | 0.0225 | 0.0225 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.01 | 0.0883 | 0.0826 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.002 | 0.002 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.0947 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.003 | 0.013 | 0.013 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0061 | 0.0061 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0053 | 0.0368 | 0.2425 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.0135 | 0.0135 |
Toxoplasma gondii | WD domain, G-beta repeat-containing protein | 0.0019 | 0.0003 | 0.0003 |
Echinococcus granulosus | receptor type guanylyl cyclase | 0.003 | 0.013 | 0.013 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0043 | 0.0265 | 0.0265 |
Toxoplasma gondii | AGC kinase | 0.0039 | 0.0225 | 0.0225 |
Echinococcus granulosus | expressed conserved protein | 0.0094 | 0.0817 | 0.0817 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0271 | 0.2724 | 0.2724 |
Echinococcus granulosus | dnaJ subfamily B | 0.0417 | 0.4293 | 0.4293 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.01 | 0.0883 | 0.0883 |
Loa Loa (eye worm) | AGC/PKA protein kinase | 0.0039 | 0.0225 | 0.0225 |
Trypanosoma brucei | protein kinase A catalytic subunit, putative | 0.0039 | 0.0225 | 0.0225 |
Echinococcus multilocularis | glutamate receptor 2 | 0.003 | 0.013 | 0.013 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0061 | 0.0061 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0947 | 1 | 1 |
Leishmania major | protein kinase A catalytic subunit isoform 1 | 0.0039 | 0.0225 | 0.0225 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0368 | 0.3768 | 0.3768 |
Onchocerca volvulus | 0.003 | 0.013 | 0.0541 | |
Echinococcus granulosus | atrial natriuretic peptide receptor | 0.003 | 0.013 | 0.013 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0053 | 0.0368 | 0.0368 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0102 | 0.0899 | 0.0899 |
Echinococcus granulosus | glutamate receptor 2 | 0.003 | 0.013 | 0.013 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0947 | 1 | 1 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0057 | 0.0416 | 0.0416 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0296 | 0.0296 |
Toxoplasma gondii | protein kinase, cAMP-dependent, catalytic chain | 0.0039 | 0.0225 | 0.0225 |
Brugia malayi | PHD-finger family protein | 0.002 | 0.002 | 0.002 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0071 | 0.0564 | 0.0564 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0296 | 0.0296 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.013 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0696 | 0.0696 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0296 | 0.0296 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0947 | 1 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.003 | 0.013 | 0.013 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0061 | 0.0061 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0039 | 0.0225 | 0.0225 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0158 | 0.1502 | 0.1502 |
Echinococcus granulosus | tyrosine kinase | 0.003 | 0.013 | 0.013 |
Echinococcus granulosus | peregrin | 0.0057 | 0.0416 | 0.0416 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0003 | 0.0003 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0143 | 0.1346 | 0.1346 |
Brugia malayi | jmjC domain containing protein | 0.0071 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.013 | 0.013 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0197 | 0.0197 |
Echinococcus multilocularis | rho associated protein kinase | 0.0142 | 0.1326 | 0.1326 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.013 | 0.013 |
Schistosoma mansoni | protein kinase | 0.003 | 0.013 | 0.013 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0083 | 0.0696 | 0.0696 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0069 | 0.0546 | 0.0546 |
Echinococcus multilocularis | protein dispatched 1 | 0.0049 | 0.0331 | 0.0331 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0039 | 0.0225 | 0.0165 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0197 | 0.0136 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0368 | 0.0368 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0053 | 0.0368 | 0.0368 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0158 | 0.1502 | 0.1502 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0071 | 0.0564 | 0.0564 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.1657 | 0.1657 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.003 | 0.013 | 0.013 |
Echinococcus multilocularis | geminin | 0.0172 | 0.1657 | 0.1657 |
Loa Loa (eye worm) | glutamate receptor | 0.0127 | 0.1174 | 0.1174 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.013 | 0.013 |
Plasmodium vivax | hypothetical protein, conserved | 0.0057 | 0.0416 | 0.0416 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0117 | 0.0117 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0324 | 0.329 | 0.329 |
Brugia malayi | Guanylyl cyclase protein 23 | 0.003 | 0.013 | 0.013 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.003 | 0.013 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.0399 | 0.4096 | 0.4096 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0249 | 0.0249 |
Echinococcus granulosus | jumonji domain containing protein | 0.0079 | 0.0657 | 0.0657 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0053 | 0.0368 | 0.2425 |
Trypanosoma brucei | PHD-zinc-finger like domain containing protein, putative | 0.0019 | 0.0003 | 0.0003 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0294 | 0.2962 | 0.2962 |
Brugia malayi | AF-10 protein | 0.0019 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0057 | 0.0416 | 0.0416 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0249 | 0.0249 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0043 | 0.0265 | 0.0265 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0117 | 0.0117 |
Plasmodium vivax | hypothetical protein, conserved | 0.002 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0118 | 0.1071 | 0.1071 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.0947 | 1 | 1 |
Echinococcus multilocularis | peregrin | 0.0057 | 0.0416 | 0.0416 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0271 | 0.2724 | 0.2724 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0296 | 0.0296 |
Loa Loa (eye worm) | glutamate receptor | 0.0324 | 0.329 | 0.329 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0083 | 0.0696 | 0.0696 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0071 | 0.0564 | 0.0564 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.003 | 0.013 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.013 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0061 | 0.0061 |
Echinococcus granulosus | geminin | 0.0172 | 0.1657 | 0.1657 |
Echinococcus multilocularis | protein patched | 0.0043 | 0.0265 | 0.0265 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0883 | 0.0883 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.003 | 0.013 | 0.013 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0117 | 0.0117 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0039 | 0.0225 | 0.0225 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0039 | 0.0225 | 0.0225 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0026 | 0.0081 | 0.0081 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0061 | 0.0061 |
Onchocerca volvulus | 0.0029 | 0.0117 | 0.0441 | |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0043 | 0.0265 | 0.0265 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0825 | 0.868 | 0.868 |
Leishmania major | extracellular receptor, putative | 0.003 | 0.013 | 0.013 |
Onchocerca volvulus | 0.0141 | 0.1318 | 0.9937 | |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0197 | 0.0136 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0055 | 0.0399 | 0.0399 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.0135 | 0.0135 |
Echinococcus multilocularis | tyrosine kinase | 0.003 | 0.013 | 0.013 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0197 | 0.0136 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.003 | 0.013 | 0.013 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.0947 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0039 | 0.0225 | 0.0225 |
Plasmodium vivax | cAMP-dependent protein kinase catalytic subunit, putative | 0.0039 | 0.0225 | 0.0225 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.0947 | 1 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0187 | 0.1815 | 0.1815 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0225 | 0.0225 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0399 | 0.4096 | 0.4096 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0368 | 0.0368 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 1 | 0.0039 | 0.0225 | 0.0225 |
Schistosoma mansoni | jumonji domain containing protein | 0.0149 | 0.1401 | 0.1401 |
Schistosoma mansoni | patched 1 | 0.0043 | 0.0265 | 0.0265 |
Echinococcus granulosus | glutamate receptor 2 | 0.003 | 0.013 | 0.013 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0019 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0296 | 0.0296 |
Brugia malayi | Protein kinase domain containing protein | 0.0439 | 0.4527 | 0.4527 |
Leishmania major | protein kinase A catalytic subunit isoform 2 | 0.0039 | 0.0225 | 0.0225 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0197 | 0.0197 |
Trypanosoma brucei | PHD-zinc-finger like domain containing protein, putative | 0.0019 | 0.0003 | 0.0003 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0947 | 1 | 1 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.003 | 0.013 | 0.013 |
Schistosoma mansoni | tyrosine kinase | 0.003 | 0.013 | 0.013 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0249 | 0.0249 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.003 | 0.013 | 0.013 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0028 | 0.0099 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0061 | 0.0061 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.003 | 0.013 | 0.013 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.0947 | 1 | 1 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0057 | 0.0416 | 0.0416 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 2 | 0.0039 | 0.0225 | 0.0225 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0062 | 0.047 | 0.047 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0414 | 0.4254 | 1 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.0947 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.003 | 0.013 | 0.013 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0057 | 0.0416 | 0.0416 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.01 | 0.0883 | 0.0883 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0296 | 0.0296 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0416 | 0.0416 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0061 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0399 | 0.4096 | 0.4096 |
Echinococcus granulosus | enhancer of mRNA decapping protein 4 | 0.0039 | 0.0217 | 0.0217 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0135 | 0.0135 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.003 | 0.013 | 0.013 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0187 | 0.1815 | 0.1815 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0197 | 0.0197 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0057 | 0.0416 | 0.0416 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0143 | 0.1346 | 0.1346 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.003 | 0.013 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0856 | 0.0856 |
Onchocerca volvulus | 0.003 | 0.013 | 0.0541 | |
Echinococcus multilocularis | enhancer of mRNA decapping protein 4 | 0.0039 | 0.0217 | 0.0217 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 3 | 0.0039 | 0.0225 | 0.0225 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 3 | 0.0039 | 0.0225 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0416 | 0.0416 |
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0039 | 0.0225 | 0.0225 |
Trypanosoma cruzi | extracellular receptor, putative | 0.003 | 0.013 | 0.013 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.0439 | 0.4527 | 0.4527 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0249 | 0.0249 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -3.16 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = -2.24 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = -0.29 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 0 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 5 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 99 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
XC50 (functional) | = 0.8456 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.