Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate NMDA receptor | No references | |
Homo sapiens | glutamate receptor, metabotropic 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | fructose-bisphospatase II | 0.137 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0271 | 0.0086 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0065 | 0.0271 | 0.0245 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.137 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.137 | 1 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.137 | 1 | 1 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.137 | 1 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0065 | 0.0271 | 0.0245 |
Leishmania major | 0.137 | 1 | 0.5 | |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0053 | 0.0187 | 0.0187 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0044 | 0.0118 | 0.0118 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0046 | 0.0128 | 0.0128 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.137 | 1 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0046 | 0.0128 | 0.0102 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.0202 | 0.0202 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0046 | 0.0128 | 0.0102 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.137 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.137 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | Agonist activity at human mGluR7 receptor expressed in HEK cells | ChEMBL. | No reference | |
EC50 (binding) | Agonist activity at human mGluR3 receptor expressed in HEK cells | ChEMBL. | No reference | |
EC50 (binding) | Agonist activity at human mGluR5 receptor expressed in HEK cells | ChEMBL. | No reference | |
EC50 (binding) | = 3 uM | Agonist activity at human mGluR1 receptor expressed in HEK cells | ChEMBL. | No reference |
EC50 (binding) | = 251 uM | Agonist activity at human mGluR2 receptor expressed in HEK cells | ChEMBL. | No reference |
EC50 (binding) | > 1000 uM | Agonist activity at human mGluR4 receptor expressed in HEK cells | ChEMBL. | No reference |
Ki (binding) | = 3.6 | Displacement of [3H]-LY341495 from human mGluR2 receptor expressed in HEK cells | ChEMBL. | No reference |
Ki (binding) | = 4.73 | Displacement of [3H]CGP-39653 from NMDA receptor in rat brain cortical membranes | ChEMBL. | No reference |
Ki (binding) | = 5.52 | Displacement of [3H]-Quisqualate from human mGluR1 receptor expressed in HEK cells | ChEMBL. | No reference |
Ki (binding) | = 19 uM | Displacement of [3H]CGP-39653 from NMDA receptor in rat brain cortical membranes | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.