Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | LIM domain kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | protein kinase | Get druggable targets OG5_131191 | All targets in OG5_131191 |
Schistosoma mansoni | protein kinase | Get druggable targets OG5_131191 | All targets in OG5_131191 |
Echinococcus granulosus | dual specificity testis-specific protein kinase | Get druggable targets OG5_131191 | All targets in OG5_131191 |
Schistosoma japonicum | ko:K05743 LIM domain kinase 1, putative | Get druggable targets OG5_131191 | All targets in OG5_131191 |
Echinococcus multilocularis | dual specificity testis specific protein kinase | Get druggable targets OG5_131191 | All targets in OG5_131191 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | wnt inhibitor frzb2 | 0.0035 | 0.1773 | 0.1773 |
Echinococcus granulosus | frizzled | 0.0035 | 0.1773 | 0.1773 |
Echinococcus multilocularis | frizzled 5 | 0.0035 | 0.1773 | 0.1773 |
Echinococcus granulosus | frizzled 5 | 0.0035 | 0.1773 | 0.1773 |
Schistosoma mansoni | frizzled-like receptor | 0.0035 | 0.1773 | 0.1773 |
Echinococcus granulosus | frizzled | 0.0035 | 0.1773 | 0.1773 |
Echinococcus multilocularis | frizzled 4 | 0.0035 | 0.1773 | 0.1773 |
Echinococcus multilocularis | secreted frizzled protein | 0.0035 | 0.1773 | 0.1773 |
Echinococcus multilocularis | netrin 1 | 0.0103 | 0.54 | 0.54 |
Echinococcus granulosus | secreted frizzled protein | 0.0035 | 0.1773 | 0.1773 |
Schistosoma mansoni | frizzled-like receptor | 0.0035 | 0.1773 | 0.1773 |
Schistosoma mansoni | netrin | 0.0103 | 0.54 | 0.54 |
Schistosoma mansoni | netrin | 0.0103 | 0.54 | 0.54 |
Echinococcus multilocularis | frizzled 10 | 0.0035 | 0.1773 | 0.1773 |
Schistosoma mansoni | protein kinase | 0.0188 | 1 | 1 |
Echinococcus multilocularis | secreted frizzled protein 5 | 0.0035 | 0.1773 | 0.1773 |
Schistosoma mansoni | secreted frizzled-related protein | 0.0035 | 0.1773 | 0.1773 |
Echinococcus granulosus | frizzled | 0.0035 | 0.1773 | 0.1773 |
Echinococcus granulosus | smoothened | 0.0035 | 0.1773 | 0.1773 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.54 | 1 |
Onchocerca volvulus | 0.0138 | 0.731 | 0.5 | |
Echinococcus granulosus | secreted frizzled protein 5 | 0.0035 | 0.1773 | 0.1773 |
Echinococcus multilocularis | frizzled | 0.0035 | 0.1773 | 0.1773 |
Echinococcus multilocularis | secreted frizzled protein | 0.0035 | 0.1773 | 0.1773 |
Echinococcus multilocularis | dual specificity testis specific protein kinase | 0.0188 | 1 | 1 |
Brugia malayi | Unc-6 protein precursor | 0.0103 | 0.54 | 1 |
Echinococcus granulosus | frizzled 4 | 0.0035 | 0.1773 | 0.1773 |
Schistosoma mansoni | protein kinase | 0.0188 | 1 | 1 |
Echinococcus multilocularis | frizzled | 0.0035 | 0.1773 | 0.1773 |
Echinococcus multilocularis | smoothened | 0.0035 | 0.1773 | 0.1773 |
Echinococcus granulosus | netrin 1 | 0.0103 | 0.54 | 0.54 |
Schistosoma mansoni | frizzled | 0.0035 | 0.1773 | 0.1773 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 294 nM | Inhibition of LIMK1 (unknown origin) assessed as ADP formation using cofilin-2 protein as substrate measured after 60 mins incubation with enzyme by Transcreener assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.