Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | secreted frizzled protein | 0.0167 | 0.0304 | 0.0457 |
Brugia malayi | Frizzled/Smoothened family membrane region containing protein | 0.0167 | 0.0304 | 0.0457 |
Echinococcus multilocularis | smoothened | 0.0167 | 0.0304 | 0.0457 |
Echinococcus multilocularis | frizzled 10 | 0.0167 | 0.0304 | 0.0457 |
Schistosoma mansoni | frizzled | 0.0167 | 0.0304 | 0.0457 |
Echinococcus granulosus | frizzled 4 | 0.0167 | 0.0304 | 0.0457 |
Echinococcus multilocularis | frizzled 5 | 0.0167 | 0.0304 | 0.0457 |
Echinococcus granulosus | secreted frizzled protein 5 | 0.0167 | 0.0304 | 0.0457 |
Schistosoma mansoni | frizzled-like receptor | 0.0167 | 0.0304 | 0.0457 |
Echinococcus granulosus | frizzled | 0.0167 | 0.0304 | 0.0457 |
Echinococcus multilocularis | secreted frizzled protein | 0.0167 | 0.0304 | 0.0457 |
Echinococcus granulosus | netrin 1 | 0.0484 | 0.6656 | 1 |
Echinococcus multilocularis | frizzled 4 | 0.0167 | 0.0304 | 0.0457 |
Loa Loa (eye worm) | frizzled/Smoothened family membrane region containing protein | 0.0167 | 0.0304 | 0.0457 |
Loa Loa (eye worm) | sfrp2 | 0.0167 | 0.0304 | 0.0457 |
Schistosoma mansoni | secreted frizzled-related protein | 0.0167 | 0.0304 | 0.0457 |
Brugia malayi | Fz domain containing protein | 0.0167 | 0.0304 | 0.0457 |
Echinococcus multilocularis | netrin 1 | 0.0484 | 0.6656 | 1 |
Echinococcus multilocularis | frizzled | 0.0167 | 0.0304 | 0.0457 |
Loa Loa (eye worm) | hypothetical protein | 0.0484 | 0.6656 | 1 |
Brugia malayi | Fz domain containing protein | 0.0167 | 0.0304 | 0.0457 |
Echinococcus granulosus | secreted frizzled protein | 0.0167 | 0.0304 | 0.0457 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0304 | 0.0457 |
Echinococcus granulosus | smoothened | 0.0167 | 0.0304 | 0.0457 |
Brugia malayi | Unc-6 protein precursor | 0.0484 | 0.6656 | 1 |
Echinococcus granulosus | frizzled | 0.0167 | 0.0304 | 0.0457 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0304 | 0.0457 |
Schistosoma mansoni | netrin | 0.0484 | 0.6656 | 1 |
Schistosoma mansoni | wnt inhibitor frzb2 | 0.0167 | 0.0304 | 0.0457 |
Schistosoma mansoni | netrin | 0.0484 | 0.6656 | 1 |
Schistosoma mansoni | frizzled-like receptor | 0.0167 | 0.0304 | 0.0457 |
Echinococcus granulosus | frizzled | 0.0167 | 0.0304 | 0.0457 |
Loa Loa (eye worm) | frizzled/Smoothened family membrane region containing protein | 0.0167 | 0.0304 | 0.0457 |
Brugia malayi | Frizzled/Smoothened family membrane region containing protein | 0.0167 | 0.0304 | 0.0457 |
Echinococcus multilocularis | secreted frizzled protein 5 | 0.0167 | 0.0304 | 0.0457 |
Echinococcus granulosus | frizzled 5 | 0.0167 | 0.0304 | 0.0457 |
Echinococcus multilocularis | frizzled | 0.0167 | 0.0304 | 0.0457 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 869 nM | Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs | ChEMBL. | 25176190 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.