Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0069 | 0.2563 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0059 | 0.1553 | 0.6061 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0069 | 0.2563 | 1 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0042 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide | 0.0059 | 0.1553 | 0.6061 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0069 | 0.2563 | 0.2563 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.2563 | 0.1195 |
Trypanosoma cruzi | endonuclease G, putative | 0.0042 | 0 | 0.5 |
Trypanosoma cruzi | endonuclease G, putative | 0.0042 | 0 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0069 | 0.2563 | 1 |
Leishmania major | endonuclease G, putative | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.2563 | 0.1195 |
Trypanosoma brucei | endonuclease G, putative | 0.0042 | 0 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0069 | 0.2563 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0069 | 0.2563 | 1 |
Trypanosoma brucei | endonuclease G, putative | 0.0042 | 0 | 0.5 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0069 | 0.2563 | 0.2563 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0059 | 0.1553 | 0.6061 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0069 | 0.2563 | 1 |
Onchocerca volvulus | 0.015 | 1 | 1 | |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0042 | 0 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.0042 | 0 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0069 | 0.2563 | 0.2563 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0069 | 0.2563 | 0.2563 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0042 | 0 | 0.5 |
Echinococcus multilocularis | ectonucleotide | 0.0059 | 0.1553 | 0.6061 |
Schistosoma mansoni | hypothetical protein | 0.015 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0069 | 0.2563 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0069 | 0.2563 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.015 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.2563 | 0.1195 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0069 | 0.2563 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0069 | 0.2563 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0069 | 0.2563 | 0.2563 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0042 | 0 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0069 | 0.2563 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 5.6 uM | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability | ChEMBL. | 25105722 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 25105722 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.