Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0092 | 0.1106 | 0.0938 |
Schistosoma mansoni | wnt related | 0.0067 | 0.0482 | 0.0676 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0142 | 0.235 | 0.3295 |
Brugia malayi | wnt family protein | 0.0067 | 0.0482 | 0.0676 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0482 | 0.0593 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0482 | 0.0593 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0092 | 0.1106 | 0.0938 |
Brugia malayi | Frizzled/Smoothened family membrane region containing protein | 0.0115 | 0.1686 | 0.2364 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0047 | 0 | 0.5 |
Echinococcus multilocularis | frizzled | 0.0115 | 0.1686 | 0.1811 |
Loa Loa (eye worm) | frizzled/Smoothened family membrane region containing protein | 0.0115 | 0.1686 | 0.2296 |
Schistosoma mansoni | wnt related | 0.0067 | 0.0482 | 0.0676 |
Entamoeba histolytica | hypothetical protein | 0.0113 | 0.1629 | 0.6931 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0142 | 0.235 | 0.2809 |
Echinococcus granulosus | secreted frizzled protein 5 | 0.0115 | 0.1686 | 0.1811 |
Echinococcus multilocularis | frizzled 10 | 0.0115 | 0.1686 | 0.1811 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0092 | 0.1106 | 0.1551 |
Brugia malayi | Frizzled/Smoothened family membrane region containing protein | 0.0115 | 0.1686 | 0.2364 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.1686 | 0.2296 |
Echinococcus multilocularis | frizzled 5 | 0.0115 | 0.1686 | 0.1811 |
Schistosoma mansoni | wnt inhibitor frzb2 | 0.0115 | 0.1686 | 0.2364 |
Schistosoma mansoni | wnt-5 | 0.0067 | 0.0482 | 0.0676 |
Schistosoma mansoni | netrin | 0.0334 | 0.7132 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0142 | 0.235 | 1 |
Brugia malayi | wnt family protein | 0.0067 | 0.0482 | 0.0676 |
Schistosoma mansoni | frizzled | 0.0115 | 0.1686 | 0.2364 |
Loa Loa (eye worm) | Wnt2 protein | 0.0067 | 0.0482 | 0.0593 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0482 | 0.0593 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0097 | 0.1244 | 0.5294 |
Echinococcus multilocularis | secreted frizzled protein | 0.0115 | 0.1686 | 0.1811 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0142 | 0.235 | 1 |
Echinococcus granulosus | frizzled | 0.0115 | 0.1686 | 0.1811 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.1106 | 0.1475 |
Brugia malayi | Unc-6 protein precursor | 0.0334 | 0.7132 | 1 |
Echinococcus granulosus | frizzled 5 | 0.0115 | 0.1686 | 0.1811 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0063 | 0.0385 | 0.1637 |
Loa Loa (eye worm) | sfrp2 | 0.0115 | 0.1686 | 0.2296 |
Schistosoma mansoni | netrin | 0.0334 | 0.7132 | 1 |
Echinococcus granulosus | frizzled 4 | 0.0115 | 0.1686 | 0.1811 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0113 | 0.1629 | 0.6931 |
Echinococcus multilocularis | netrin 1 | 0.0334 | 0.7132 | 1 |
Loa Loa (eye worm) | wnt-4 protein | 0.0067 | 0.0482 | 0.0593 |
Loa Loa (eye worm) | CWN-2 protein | 0.0067 | 0.0482 | 0.0593 |
Brugia malayi | Wnt-2 protein precursor | 0.0067 | 0.0482 | 0.0676 |
Schistosoma mansoni | frizzled-like receptor | 0.0115 | 0.1686 | 0.2364 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0113 | 0.1629 | 0.2215 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0142 | 0.235 | 0.3295 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0482 | 0.0593 |
Echinococcus granulosus | frizzled | 0.0115 | 0.1686 | 0.1811 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0138 | 0.2245 | 0.9555 |
Echinococcus granulosus | frizzled | 0.0115 | 0.1686 | 0.1811 |
Loa Loa (eye worm) | frizzled/Smoothened family membrane region containing protein | 0.0115 | 0.1686 | 0.2296 |
Schistosoma mansoni | wnt related | 0.0067 | 0.0482 | 0.0676 |
Brugia malayi | wnt family protein | 0.0067 | 0.0482 | 0.0676 |
Schistosoma mansoni | wnt related | 0.0067 | 0.0482 | 0.0676 |
Schistosoma mansoni | frizzled-like receptor | 0.0115 | 0.1686 | 0.2364 |
Echinococcus multilocularis | frizzled | 0.0115 | 0.1686 | 0.1811 |
Loa Loa (eye worm) | hypothetical protein | 0.0334 | 0.7132 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0097 | 0.1244 | 0.5294 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0482 | 0.0593 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0142 | 0.235 | 1 |
Echinococcus granulosus | secreted frizzled protein | 0.0115 | 0.1686 | 0.1811 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0142 | 0.235 | 1 |
Schistosoma mansoni | secreted frizzled-related protein | 0.0115 | 0.1686 | 0.2364 |
Echinococcus multilocularis | smoothened | 0.0115 | 0.1686 | 0.1811 |
Echinococcus multilocularis | secreted frizzled protein 5 | 0.0115 | 0.1686 | 0.1811 |
Echinococcus granulosus | netrin 1 | 0.0334 | 0.7132 | 1 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0068 | 0.0523 | 0.5 |
Brugia malayi | wnt family protein | 0.0067 | 0.0482 | 0.0676 |
Brugia malayi | Fz domain containing protein | 0.0115 | 0.1686 | 0.2364 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0142 | 0.235 | 0.2809 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.1686 | 0.2296 |
Echinococcus multilocularis | frizzled 4 | 0.0115 | 0.1686 | 0.1811 |
Brugia malayi | Wnt-4 protein precursor | 0.0067 | 0.0482 | 0.0676 |
Echinococcus granulosus | smoothened | 0.0115 | 0.1686 | 0.1811 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0142 | 0.235 | 1 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0142 | 0.235 | 1 |
Echinococcus multilocularis | secreted frizzled protein | 0.0115 | 0.1686 | 0.1811 |
Brugia malayi | Fz domain containing protein | 0.0115 | 0.1686 | 0.2364 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.6 uM | Inhibition of PI3Kgamma (unknown origin) assessed as decrease in fluorescence intensity using phosphorylated substrate | ChEMBL. | 25050878 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.