Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | monoacylglycerol O-acyltransferase 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | diacylglycerol acyltransferase, putative | monoacylglycerol O-acyltransferase 2 | 334 aa | 297 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0098 | 0.6539 | 0.5 | |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0128 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0128 | 1 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0073 | 0.368 | 0.5 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0073 | 0.368 | 0.5627 |
Loa Loa (eye worm) | ILVBL protein | 0.0077 | 0.4171 | 0.1677 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0128 | 1 | 1 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0128 | 1 | 1 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0098 | 0.6539 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0073 | 0.368 | 0.5 |
Toxoplasma gondii | dgat2l1-prov protein | 0.0098 | 0.6539 | 0.5 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0073 | 0.368 | 0.368 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0098 | 0.6539 | 1 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0098 | 0.6539 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.0109 | 0.7851 | 1 |
Leishmania major | diacylglycerol acyltransferase, putative | 0.0098 | 0.6539 | 1 |
Trypanosoma brucei | diacylglycerol acyltransferase, putative | 0.0098 | 0.6539 | 1 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0073 | 0.368 | 0.368 |
Schistosoma mansoni | acetolactate synthase | 0.0109 | 0.7851 | 1 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0128 | 1 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase | 0.0073 | 0.368 | 0.368 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0128 | 1 | 1 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0128 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.8 nM | Inhibition of human MoGAT-2 expressed in human Caco2 cells assessed as inhibition of 2-O-Hexadecylglycerol hydrolysis pretreated for 30 mins by LC-MS analysis | ChEMBL. | 25147598 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.