Detailed information for compound 927053

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 306.319 | Formula: C17H14N4O2
  • H donors: 1 H acceptors: 3 LogP: 4.04 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(N/N=C/c2cccc(c2)[N+](=O)[O-])c2c(n1)cccc2
  • InChi: 1S/C17H14N4O2/c1-12-9-17(15-7-2-3-8-16(15)19-12)20-18-11-13-5-4-6-14(10-13)21(22)23/h2-11H,1H3,(H,19,20)/b18-11+
  • InChiKey: RLRLQZGKWYQMBV-WOJGMQOQSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein kinase csk 0.0035 0.1194 0.1194
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0161 1 1
Plasmodium falciparum protein kinase, putative 0.0035 0.1194 1
Echinococcus multilocularis activated cdc42 kinase 1 0.0035 0.1194 0.1194
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0126 0.7528 0.7528
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.1194 0.1194
Echinococcus granulosus tyrosine protein kinase pr2 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Onchocerca volvulus 0.0126 0.7528 0.7192
Plasmodium vivax tyrosine kinase-like protein, putative 0.0035 0.1194 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0035 0.1194 0.1194
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Loa Loa (eye worm) TK/FER protein kinase 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.1194 0.5
Echinococcus multilocularis tyrosine protein kinase Abl 0.0161 1 1
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Echinococcus multilocularis tensin 0.0126 0.7528 0.7528
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0126 0.7528 0.7528
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Echinococcus multilocularis ephrin type A receptor 4 A 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0126 0.7528 0.7528
Brugia malayi SH2 domain containing protein 0.0126 0.7528 0.7528
Schistosoma mansoni suppressor of cytokine signaling 0.0126 0.7528 0.7528
Echinococcus multilocularis tyrosine protein kinase csk 0.0035 0.1194 0.1194
Loa Loa (eye worm) TK/FER protein kinase 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Echinococcus multilocularis activin receptor type 0.0035 0.1194 0.1194
Brugia malayi Protein kinase domain containing protein 0.0161 1 1
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0035 0.1194 0.1194
Echinococcus multilocularis tyrosine protein kinase HCK 0.0035 0.1194 0.1194
Onchocerca volvulus 0.0126 0.7528 0.7192
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0035 0.1194 0.1194
Brugia malayi C-terminal src kinase protein 1 0.0035 0.1194 0.1194
Schistosoma mansoni protein kinase 0.0035 0.1194 0.1194
Echinococcus multilocularis tyrosine protein kinase pr2 0.0035 0.1194 0.1194
Loa Loa (eye worm) TK/FER protein kinase 0.0035 0.1194 0.1194
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0035 0.1194 0.1194
Brugia malayi Immunoglobulin I-set domain containing protein 0.0035 0.1194 0.1194
Loa Loa (eye worm) TK protein kinase 0.0035 0.1194 0.1194
Echinococcus granulosus raf serine:threonine protein kinase 0.0035 0.1194 0.1194
Echinococcus granulosus tyrosine kinase 0.0035 0.1194 0.1194
Brugia malayi Variant SH3 domain containing protein 0.0126 0.7528 0.7528
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Schistosoma mansoni tyrosine kinase 0.0161 1 1
Brugia malayi Receptor family ligand binding region containing protein 0.0035 0.1194 0.1194
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Echinococcus multilocularis 0.0126 0.7528 0.7528
Brugia malayi hypothetical protein 0.0161 1 1
Echinococcus multilocularis tensin 0.0126 0.7528 0.7528
Schistosoma mansoni hypothetical protein 0.0126 0.7528 0.7528
Echinococcus granulosus tyrosine protein kinase Srms 0.0161 1 1
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0035 0.1194 1
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0035 0.1194 0.1194
Echinococcus granulosus tyrosine kinase 0.0161 1 1
Echinococcus granulosus epidermal growth factor receptor 0.0035 0.1194 0.1194
Entamoeba histolytica protein kinase, putative 0.0126 0.7528 0.7192
Loa Loa (eye worm) TK/Met protein kinase 0.0035 0.1194 0.1194
Loa Loa (eye worm) hypothetical protein 0.0039 0.1479 0.1479
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0161 1 1
Echinococcus granulosus activated cdc42 kinase 1 0.0035 0.1194 0.1194
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Echinococcus multilocularis kinase suppressor of Ras 1 0.0035 0.1194 0.1194
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0161 1 1
Brugia malayi tRNA modification GTPase TrmE family protein 0.0126 0.7528 0.7528
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0161 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2756 0.2756
Loa Loa (eye worm) RGC/RGC protein kinase 0.0035 0.1194 0.1194
Schistosoma mansoni protein tyrosine kinase 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0035 0.1194 0.1194
Echinococcus granulosus hypothetical protein 0.0126 0.7528 0.7528
Brugia malayi Protein kinase domain containing protein 0.0161 1 1
Brugia malayi Variant SH3 domain containing protein 0.0126 0.7528 0.7528
Onchocerca volvulus 0.0161 1 1
Brugia malayi RhoGAP domain containing protein 0.0126 0.7528 0.7528
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Brugia malayi Variant SH3 domain containing protein 0.0126 0.7528 0.7528
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0035 0.1194 0.1194
Echinococcus multilocularis tyrosine protein kinase Srms 0.0161 1 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0126 0.7528 0.7528
Schistosoma mansoni hypothetical protein 0.0035 0.1194 0.1194
Echinococcus granulosus natriuretic peptide receptor 1 0.0035 0.1194 0.1194
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0126 0.7528 0.7528
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0035 0.1194 0.1194
Loa Loa (eye worm) hypothetical protein 0.0126 0.7528 0.7528
Onchocerca volvulus 0.0126 0.7528 0.7192
Loa Loa (eye worm) hypothetical protein 0.0126 0.7528 0.7528
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0126 0.7528 0.7528
Loa Loa (eye worm) hypothetical protein 0.0126 0.7528 0.7528
Echinococcus granulosus tyrosine protein kinase Fyn 0.0161 1 1
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Loa Loa (eye worm) TK protein kinase 0.0035 0.1194 0.1194
Schistosoma mansoni protein kinase 0.0035 0.1194 0.1194
Onchocerca volvulus 0.0126 0.7528 0.7192
Toxoplasma gondii protein kinase 0.0035 0.1194 1
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Echinococcus granulosus ephrin type A receptor 4 A 0.0035 0.1194 0.1194
Echinococcus granulosus tyrosine protein kinase Src42A 0.0161 1 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0035 0.1194 0.1194
Loa Loa (eye worm) hypothetical protein 0.0126 0.7528 0.7528
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0126 0.7528 0.7528
Loa Loa (eye worm) protein kinase domain-containing protein 0.0035 0.1194 0.1194
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0126 0.7528 0.7528
Loa Loa (eye worm) TK protein kinase 0.0035 0.1194 0.1194
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.2756 0.2756
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0035 0.1194 1
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0126 0.7528 0.7528
Trypanosoma cruzi protein kinase, putative 0.0035 0.1194 1
Brugia malayi Furin-like cysteine rich region family protein 0.0035 0.1194 0.1194
Echinococcus multilocularis protein tyrosine kinase 0.0035 0.1194 0.1194
Brugia malayi Guanylyl cyclase protein 23 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Echinococcus granulosus retinal guanylyl cyclase 2 0.0035 0.1194 0.1194
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0126 0.7528 0.7528
Echinococcus multilocularis SHC transforming protein 3 0.0126 0.7528 0.7528
Loa Loa (eye worm) hypothetical protein 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Schistosoma mansoni suppressor of cytokine signaling 0.0126 0.7528 0.7528
Trichomonas vaginalis protein tyrosine kinase, putative 0.0035 0.1194 0.5
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0035 0.1194 0.5
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Trichomonas vaginalis AGC family protein kinase 0.0035 0.1194 0.5
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Brugia malayi hypothetical protein 0.0035 0.1194 0.1194
Loa Loa (eye worm) TK protein kinase 0.0035 0.1194 0.1194
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0035 0.1194 0.5
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0126 0.7528 0.7528
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Echinococcus granulosus tyrosine protein kinase shark 0.0161 1 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0035 0.1194 0.1194
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0126 0.7528 0.7528
Loa Loa (eye worm) hypothetical protein 0.0126 0.7528 0.7528
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Loa Loa (eye worm) hypothetical protein 0.0126 0.7528 0.7528
Loa Loa (eye worm) hypothetical protein 0.0035 0.1194 0.1194
Echinococcus multilocularis receptor type guanylyl cyclase 0.0035 0.1194 0.1194
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0035 0.1194 0.1194
Echinococcus multilocularis SH2 motif 0.0126 0.7528 0.7528
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.1194 0.1194
Echinococcus granulosus tyrosine protein kinase csk 0.0035 0.1194 0.1194
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.1479 0.1479
Loa Loa (eye worm) TK/ACK protein kinase 0.0035 0.1194 0.1194
Loa Loa (eye worm) hypothetical protein 0.0035 0.1194 0.1194
Echinococcus multilocularis raf serine:threonine protein kinase 0.0035 0.1194 0.1194
Loa Loa (eye worm) TK/FER protein kinase 0.0161 1 1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0035 0.1194 0.1194
Echinococcus granulosus suppressor of cytokine signaling 6 0.0126 0.7528 0.7528
Brugia malayi SRC-1 0.0161 1 1
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Brugia malayi protein-tyrosine kinase 0.0161 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.2756 0.2756
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Echinococcus multilocularis protein kinase 0.0035 0.1194 0.1194
Echinococcus granulosus SH2 domain containing adapter protein F 0.0126 0.7528 0.7528
Loa Loa (eye worm) TK/ALK protein kinase 0.0035 0.1194 0.1194
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.1194 0.5
Echinococcus granulosus tyrosine protein kinase ABL1 0.0161 1 1
Schistosoma mansoni protein kinase 0.0035 0.1194 0.1194
Trichomonas vaginalis protein kinase atn1, putative 0.0035 0.1194 0.5
Brugia malayi SH2 domain containing protein 0.0126 0.7528 0.7528
Trichomonas vaginalis STE family protein kinase 0.0035 0.1194 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.1194 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Onchocerca volvulus 0.0161 1 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0161 1 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0161 1 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0161 1 1
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Schistosoma mansoni serine/threonine RGC 0.0035 0.1194 0.1194
Loa Loa (eye worm) TK protein kinase 0.0035 0.1194 0.1194
Echinococcus granulosus kinase suppressor of Ras 1 0.0035 0.1194 0.1194
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0035 0.1194 1
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Schistosoma mansoni growth factor receptor-bound protein 0.0126 0.7528 0.7528
Trypanosoma brucei protein kinase, putative 0.0035 0.1194 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0126 0.7528 0.7528
Echinococcus granulosus activin receptor type 0.0035 0.1194 0.1194
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.1194 0.5
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0161 1 1
Plasmodium falciparum tyrosine kinase-like protein 0.0035 0.1194 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.1194 0.5
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0035 0.1194 1
Echinococcus granulosus fibroblast growth factor receptor 4 0.0035 0.1194 0.1194
Schistosoma mansoni tensin 0.0126 0.7528 0.7528
Onchocerca volvulus 0.0161 1 1
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Loa Loa (eye worm) TK/FER protein kinase 0.0161 1 1
Echinococcus multilocularis heat shock protein 70 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.1194 0.1194
Echinococcus granulosus tyrosine protein kinase Fyn 0.0161 1 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0035 0.1194 0.1194
Toxoplasma gondii protein kinase domain-containing protein 0.0035 0.1194 1
Loa Loa (eye worm) TK/FER protein kinase 0.0161 1 1
Echinococcus granulosus tyrosine kinase 0.0161 1 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0035 0.1194 0.1194
Loa Loa (eye worm) hypothetical protein 0.0126 0.7528 0.7528
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Schistosoma mansoni tensin 0.0126 0.7528 0.7528
Schistosoma mansoni tensin 0.0126 0.7528 0.7528
Loa Loa (eye worm) TK/CSK protein kinase 0.0035 0.1194 0.1194
Schistosoma mansoni tyrosine kinase 0.0161 1 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0035 0.1194 0.1194
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Trypanosoma brucei Pseudokinase, putative 0.0035 0.1194 1
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Loa Loa (eye worm) TK protein kinase 0.0161 1 1
Echinococcus granulosus expressed conserved protein 0.0126 0.7528 0.7528
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Schistosoma mansoni GTPase activating protein 0.0126 0.7528 0.7528
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.1194 0.1194
Brugia malayi SH2 domain containing protein 0.0126 0.7528 0.7528
Loa Loa (eye worm) RGC/RGC protein kinase 0.0035 0.1194 0.1194
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0126 0.7528 0.7192
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0161 1 1
Schistosoma mansoni protein kinase 0.0035 0.1194 0.1194
Leishmania major protein kinase, putative 0.0035 0.1194 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0161 1 1
Brugia malayi Sex muscle abnormal protein 5 0.0126 0.7528 0.7528
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0035 0.1194 0.1194
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0161 1 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0126 0.7528 0.7528
Brugia malayi SH2 domain containing protein 0.0126 0.7528 0.7528
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Loa Loa (eye worm) hypothetical protein 0.0035 0.1194 0.1194
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0035 0.1194 0.1194
Echinococcus granulosus protein tyrosine kinase 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Echinococcus granulosus protein kinase 0.0035 0.1194 0.1194
Echinococcus multilocularis tyrosine kinase 0.0161 1 1
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0035 0.1194 0.1194
Loa Loa (eye worm) TK/FAK protein kinase 0.0035 0.1194 0.1194
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0126 0.7528 0.7528
Echinococcus multilocularis SH2 domain containing protein 7 0.0126 0.7528 0.7528
Echinococcus multilocularis tyrosine kinase 0.0035 0.1194 0.1194
Echinococcus granulosus tyrosine protein kinase Src42A 0.0126 0.7528 0.7528
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0035 0.1194 0.1194
Giardia lamblia Kinase 0.0035 0.1194 0.5
Echinococcus granulosus growth factor receptor bound protein 2 0.0126 0.7528 0.7528
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Schistosoma mansoni nck2/grb4 0.0126 0.7528 0.7528
Echinococcus multilocularis protein KINase family member (kin 25) 0.0035 0.1194 0.1194
Echinococcus multilocularis tyrosine protein kinase csk 0.0035 0.1194 0.1194
Schistosoma mansoni protein kinase 0.0035 0.1194 0.1194
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Giardia lamblia Protein 21.1 0.0035 0.1194 0.5
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0161 1 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.7528 0.7528
Echinococcus granulosus activated cdc42 kinase 1 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0161 1 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0161 1 1
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0126 0.7528 0.7192
Loa Loa (eye worm) TK/FER protein kinase 0.0161 1 1
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0035 0.1194 0.1194
Echinococcus multilocularis c src tyrosine kinase 0.0161 1 1
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Loa Loa (eye worm) hypothetical protein 0.0035 0.1194 0.1194
Schistosoma mansoni shc transforming protein 0.0126 0.7528 0.7528
Loa Loa (eye worm) TK/FER protein kinase 0.0161 1 1
Schistosoma mansoni adapter molecule crk 0.0126 0.7528 0.7528
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0126 0.7528 0.7528
Loa Loa (eye worm) hypothetical protein 0.0126 0.7528 0.7528
Loa Loa (eye worm) hypothetical protein 0.0126 0.7528 0.7528
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0035 0.1194 0.1194
Schistosoma mansoni tyrosine kinase 0.0161 1 1
Loa Loa (eye worm) TK protein kinase 0.0035 0.1194 0.1194
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0126 0.7528 0.7528
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0035 0.1194 0.1194
Brugia malayi STAT protein, DNA binding domain containing protein 0.0126 0.7528 0.7528
Echinococcus granulosus tyrosine protein kinase HCK 0.0035 0.1194 0.1194
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0035 0.1194 0.1194
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0126 0.7528 0.7528
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Loa Loa (eye worm) TK protein kinase 0.0035 0.1194 0.1194
Loa Loa (eye worm) STAT protein 0.0126 0.7528 0.7528
Loa Loa (eye worm) TK/FER protein kinase 0.0035 0.1194 0.1194
Echinococcus granulosus SH2 motif 0.0126 0.7528 0.7528
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0161 1 1
Schistosoma mansoni tyrosine protein kinase 0.0035 0.1194 0.1194
Entamoeba histolytica SH2 domain containing protein 0.0126 0.7528 0.7192
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0035 0.1194 0.1194
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0035 0.1194 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0035 0.1194 0.1194
Schistosoma mansoni tyrosine kinase 0.0161 1 1
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Echinococcus granulosus tyrosine protein kinase 0.0035 0.1194 0.1194
Echinococcus granulosus integrin linked protein kinase 0.0035 0.1194 0.1194
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0035 0.1194 0.5
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0161 1 1
Schistosoma mansoni SH2A 0.0126 0.7528 0.7528
Schistosoma mansoni ephrin receptor 0.0035 0.1194 0.1194
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0035 0.1194 0.1194
Loa Loa (eye worm) TK protein kinase 0.0035 0.1194 0.1194
Schistosoma mansoni protein kinase 0.0035 0.1194 0.1194
Echinococcus multilocularis tyrosine protein kinase csk 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Schistosoma mansoni tensin-related 0.0126 0.7528 0.7528
Schistosoma mansoni tyrosine kinase 0.0161 1 1
Brugia malayi SH2 domain containing protein 0.0161 1 1
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0035 0.1194 0.1194
Loa Loa (eye worm) TK/EGFR protein kinase 0.0035 0.1194 0.1194
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0035 0.1194 0.1194
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0126 0.7528 0.7528
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Echinococcus granulosus SHC transforming protein 3 0.0126 0.7528 0.7528
Loa Loa (eye worm) TK/FER protein kinase 0.0161 1 1
Echinococcus granulosus SH2 domain containing protein 7 0.0126 0.7528 0.7528
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0035 0.1194 0.1194
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0126 0.7528 0.7528
Echinococcus granulosus signal transduction protein lnk realted 0.0126 0.7528 0.7528
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.1194 0.1194
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Brugia malayi Tensin 0.0126 0.7528 0.7528
Echinococcus multilocularis transfer RNA-Thr 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Plasmodium falciparum protein kinase, putative 0.0035 0.1194 1
Brugia malayi SH2 domain containing protein 0.0126 0.7528 0.7528
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0035 0.1194 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0161 1 1
Leishmania major protein kinase, putative 0.0035 0.1194 1
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Echinococcus granulosus tensin 0.0126 0.7528 0.7528
Loa Loa (eye worm) TK/FER protein kinase 0.0161 1 1
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0161 1 1
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0035 0.1194 0.1194
Loa Loa (eye worm) serine/threonine protein kinase 0.0035 0.1194 0.1194
Loa Loa (eye worm) TK/FER protein kinase 0.0161 1 1
Echinococcus multilocularis epidermal growth factor receptor 0.0035 0.1194 0.1194
Brugia malayi SH2 domain containing protein 0.0126 0.7528 0.7528
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0126 0.7528 0.7528
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.1194 0.1194
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0035 0.1194 0.1194
Echinococcus granulosus tyrosine protein kinase Blk 0.0161 1 1
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Echinococcus multilocularis N chimaerin 0.0126 0.7528 0.7528
Loa Loa (eye worm) SH2 domain-containing protein 0.0126 0.7528 0.7528
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0126 0.7528 0.7528
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0126 0.7528 0.7528
Schistosoma mansoni protein kinase 0.0035 0.1194 0.1194
Loa Loa (eye worm) hypothetical protein 0.0035 0.1194 0.1194
Echinococcus multilocularis SH2 motif 0.0126 0.7528 0.7528
Loa Loa (eye worm) hypothetical protein 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Onchocerca volvulus 0.0126 0.7528 0.7192
Loa Loa (eye worm) hypothetical protein 0.0126 0.7528 0.7528
Onchocerca volvulus 0.0161 1 1
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0161 1 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0035 0.1194 0.1194
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Giardia lamblia Kinase, NEK 0.0035 0.1194 0.5
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0126 0.7528 0.7528
Loa Loa (eye worm) TK/FER protein kinase 0.0161 1 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0161 1 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0035 0.1194 0.1194
Brugia malayi Variant SH3 domain containing protein 0.0126 0.7528 0.7528
Echinococcus granulosus suppressor of cytokine signaling 7 0.0126 0.7528 0.7528
Echinococcus multilocularis NCK adaptor protein 0.0126 0.7528 0.7528
Brugia malayi SH2 domain containing protein 0.0126 0.7528 0.7528
Brugia malayi bone morphogenetic protein type 1 receptor 0.0035 0.1194 0.1194
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0161 1 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.7528 0.7528
Plasmodium falciparum tyrosine kinase-like protein 0.0035 0.1194 1
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Echinococcus granulosus tyrosine protein kinase csk 0.0035 0.1194 0.1194
Loa Loa (eye worm) TK/ABL protein kinase 0.0161 1 1
Brugia malayi Protein kinase domain containing protein 0.0161 1 1
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Schistosoma mansoni tensin-related 0.0126 0.7528 0.7528
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Trichomonas vaginalis TK family protein kinase 0.0035 0.1194 0.5
Loa Loa (eye worm) TK/DDR protein kinase 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0035 0.1194 1
Brugia malayi Raf kinase 0.0035 0.1194 0.1194
Trypanosoma brucei Flagellum attachment zone protein 20 0.0035 0.1194 1
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Echinococcus granulosus epidermal growth factor receptor 0.0035 0.1194 0.1194
Schistosoma mansoni hypothetical protein 0.0039 0.1479 0.1479
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Loa Loa (eye worm) hypothetical protein 0.0035 0.1194 0.1194
Loa Loa (eye worm) hypothetical protein 0.0126 0.7528 0.7528
Giardia lamblia Kinase, NEK 0.0035 0.1194 0.5
Echinococcus multilocularis signal transduction protein lnk realted 0.0126 0.7528 0.7528
Loa Loa (eye worm) TK/FER protein kinase 0.0035 0.1194 0.1194
Brugia malayi hypothetical protein 0.0126 0.7528 0.7528
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0161 1 1
Echinococcus multilocularis FL cytokine receptor 0.0035 0.1194 0.1194
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0035 0.1194 0.1194
Echinococcus multilocularis natriuretic peptide receptor 1 0.0035 0.1194 0.1194
Schistosoma mansoni growth factor receptor-bound protein 0.0126 0.7528 0.7528
Echinococcus granulosus N chimaerin 0.0126 0.7528 0.7528
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0126 0.7528 0.7528
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0035 0.1194 0.1194
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0035 0.1194 0.1194
Echinococcus multilocularis tyrosine protein kinase 0.0035 0.1194 0.1194
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0035 0.1194 0.1194
Echinococcus multilocularis epidermal growth factor receptor 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.1194 0.5
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Echinococcus granulosus c src tyrosine kinase 0.0161 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0161 1 1
Schistosoma mansoni protein kinase 0.0035 0.1194 0.1194
Brugia malayi hypothetical protein 0.0035 0.1194 0.1194
Loa Loa (eye worm) RGC/RGC protein kinase 0.0035 0.1194 0.1194
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0035 0.1194 0.5
Trypanosoma cruzi protein kinase, putative 0.0035 0.1194 1
Onchocerca volvulus 0.0161 1 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0035 0.1194 1
Loa Loa (eye worm) hypothetical protein 0.0161 1 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0035 0.1194 0.1194
Brugia malayi SH2 domain containing protein 0.0161 1 1
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Echinococcus granulosus retinal guanylyl cyclase 2 0.0035 0.1194 0.1194
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0161 1 1
Schistosoma mansoni protein kinase 0.0035 0.1194 0.1194
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Loa Loa (eye worm) hypothetical protein 0.0035 0.1194 0.1194
Echinococcus multilocularis insulin receptor 0.0035 0.1194 0.1194
Loa Loa (eye worm) TK/FER protein kinase 0.0035 0.1194 0.1194
Echinococcus granulosus SH2 motif 0.0126 0.7528 0.7528
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.1194 0.5
Loa Loa (eye worm) TK/ROR protein kinase 0.0035 0.1194 0.1194
Echinococcus multilocularis growth factor receptor bound protein 2 0.0126 0.7528 0.7528
Schistosoma mansoni tyrosine kinase 0.0161 1 1
Schistosoma mansoni signal transduction protein lnk-related 0.0126 0.7528 0.7528
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Schistosoma mansoni ephrin receptor 0.0035 0.1194 0.1194
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0035 0.1194 0.1194
Brugia malayi Tyrosine-protein kinase PR2 0.0035 0.1194 0.1194
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0035 0.1194 0.1194
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0126 0.7528 0.7528
Toxoplasma gondii STE kinase 0.0035 0.1194 1
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.1194 0.1194
Loa Loa (eye worm) SH2 domain-containing protein 0.0126 0.7528 0.7528
Onchocerca volvulus 0.0126 0.7528 0.7192
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0161 1 1
Plasmodium vivax protein kinase, putative 0.0035 0.1194 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0035 0.1194 0.1194
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Brugia malayi cytokine inducible SH2-containing protein 5 0.0126 0.7528 0.7528
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0035 0.1194 0.1194
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0126 0.7528 0.7192
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0035 0.1194 0.1194
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0035 0.1194 0.1194
Loa Loa (eye worm) RGC/RGC protein kinase 0.0035 0.1194 0.1194
Leishmania major hypothetical protein, conserved 0.0035 0.1194 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.1194 0.5
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0161 1 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Schistosoma mansoni hypothetical protein 0.0126 0.7528 0.7528
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Brugia malayi Protein kinase domain containing protein 0.0035 0.1194 0.1194
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0035 0.1194 0.1194
Loa Loa (eye worm) hypothetical protein 0.0126 0.7528 0.7528
Brugia malayi ephrin receptor 1 precursor 0.0035 0.1194 0.1194
Onchocerca volvulus 0.0161 1 1
Brugia malayi integrin-linked kinase 0.0035 0.1194 0.1194
Echinococcus multilocularis integrin linked protein kinase 0.0035 0.1194 0.1194
Echinococcus multilocularis protein kinase 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Loa Loa (eye worm) TK protein kinase 0.0035 0.1194 0.1194
Loa Loa (eye worm) TK/RYK protein kinase 0.0035 0.1194 0.1194
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0035 0.1194 0.1194
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Plasmodium falciparum protein kinase, putative 0.0035 0.1194 1
Echinococcus granulosus NCK adaptor protein 0.0126 0.7528 0.7528
Loa Loa (eye worm) SH2 domain-containing protein 0.0126 0.7528 0.7528
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0161 1 1
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.2756 0.2756
Echinococcus granulosus receptor type guanylyl cyclase 0.0035 0.1194 0.1194
Schistosoma mansoni protein kinase 0.0035 0.1194 0.1194
Loa Loa (eye worm) SRC-1 0.0161 1 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.7528 0.7528
Brugia malayi Protein kinase domain containing protein 0.0161 1 1
Echinococcus multilocularis SH2 motif 0.0126 0.7528 0.7528
Trichomonas vaginalis TKL family protein kinase 0.0035 0.1194 0.5
Echinococcus granulosus insulin receptor 0.0035 0.1194 0.1194
Schistosoma mansoni protein kinase 0.0035 0.1194 0.1194
Schistosoma mansoni vav2 0.0126 0.7528 0.7528
Schistosoma mansoni tyrosine kinase 0.0035 0.1194 0.1194

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 1.27 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 1.39 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 3 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 4.98 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 98 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 100 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
XC50 (functional) = 0.72801 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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