Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carbonic anhydrase II | 0.015 | 0.0809 | 1 |
Trichomonas vaginalis | excision repair cross-complementing 1 ercc1, putative | 0.0108 | 0.0447 | 0.0272 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0361 | 0.2613 | 1 |
Plasmodium vivax | ERCC1 nucleotide excision repair protein, putative | 0.0108 | 0.0447 | 1 |
Toxoplasma gondii | ERCC4 domain-containing protein | 0.0077 | 0.0179 | 0.4015 |
Echinococcus multilocularis | carbonic anhydrase II | 0.015 | 0.0809 | 1 |
Schistosoma mansoni | excision repair cross-complementing 1 ercc1 | 0.0108 | 0.0447 | 0.1156 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0361 | 0.2613 | 0.5907 |
Entamoeba histolytica | DNA excision repair protein, putative | 0.0108 | 0.0447 | 0.0726 |
Echinococcus granulosus | DNA excision repair protein ERCC 1 | 0.0108 | 0.0447 | 0.5525 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.026 | 0.1746 | 0.031 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0507 | 0.3864 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.015 | 0.0809 | 0.2093 |
Toxoplasma gondii | DNA repair protein rad10 subfamily protein | 0.0108 | 0.0447 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.1102 | 0.4218 |
Plasmodium falciparum | DNA repair endonuclease, putative | 0.0067 | 0.01 | 0.2228 |
Echinococcus multilocularis | DNA excision repair protein ERCC 1 | 0.0108 | 0.0447 | 0.5525 |
Onchocerca volvulus | Putative sulfate transporter | 0.0205 | 0.1278 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0361 | 0.2613 | 1 |
Onchocerca volvulus | 0.0205 | 0.1278 | 0.5 | |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0361 | 0.2613 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0507 | 0.3864 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0507 | 0.3864 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1224 | 1 | 1 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0484 | 0.3668 | 0.3344 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.015 | 0.0809 | 0.2093 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.015 | 0.0809 | 0.3094 |
Plasmodium falciparum | ERCC1 nucleotide excision repair protein, putative | 0.0108 | 0.0447 | 1 |
Brugia malayi | Helix-hairpin-helix motif family protein | 0.0061 | 0.0047 | 0.018 |
Echinococcus multilocularis | dna repair endonuclease xpf | 0.0077 | 0.0179 | 0.2218 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.015 | 0.0809 | 0.3094 |
Schistosoma mansoni | DNA repair endonuclease xp-f / mei-9 / rad1 | 0.0077 | 0.0179 | 0.0464 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0976 | 0.7882 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1224 | 1 | 1 |
Loa Loa (eye worm) | ERCC4 domain-containing protein | 0.0077 | 0.0179 | 0.0686 |
Loa Loa (eye worm) | helix-hairpin-helix domain-containing protein family protein | 0.0108 | 0.0447 | 0.171 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.015 | 0.0809 | 0.3094 |
Brugia malayi | ERCC4 domain containing protein | 0.0077 | 0.0179 | 0.0686 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0361 | 0.2613 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.015 | 0.0809 | 0.3094 |
Echinococcus granulosus | dna repair endonuclease xpf | 0.0077 | 0.0179 | 0.2218 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0507 | 0.3864 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 97 % | Cytotoxicity against human MV4-11 cells assessed as cell viability at 1 uM after 48 hrs by MTT assay | ChEMBL. | 25089810 |
IC50 (functional) | > 500 nM | Cytotoxicity against human MOLM13 cells assessed as cell viability after 48 hrs by MTT assay | ChEMBL. | 25089810 |
Inhibition (binding) | = 6 % | Inhibition of FLT3 (unknown origin) using EAIYAAPFAKKK substrate at 1 uM | ChEMBL. | 25089810 |
Inhibition (binding) | = 13 % | Inhibition of Aurora B (unknown origin) using HLRRASLG substrate at 1 uM | ChEMBL. | 25089810 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 25089810 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.