Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cryptosporidium parvum | inosine-5-monophosphate dehydrogenase | Starlite/ChEMBL | References |
Bacillus anthracis | Inosine-5'-monophosphate dehydrogenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | tRNA pseudouridine synthase-like 1 homolog | Inosine-5'-monophosphate dehydrogenase | 487 aa | 484 aa | 40.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/FER protein kinase | 0.0116 | 0.1326 | 0.1326 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0228 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0116 | 0.1326 | 0.1326 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0223 | 0.9567 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0116 | 0.1326 | 0.1326 |
Trypanosoma cruzi | GMP reductase | 0.0228 | 1 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0116 | 0.1326 | 0.1326 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0116 | 0.1326 | 0.1326 |
Brugia malayi | SH2 domain containing protein | 0.0116 | 0.1326 | 0.1326 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0228 | 1 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0116 | 0.1326 | 0.1326 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0116 | 0.1326 | 0.1326 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0116 | 0.1326 | 0.1326 |
Trypanosoma cruzi | GMP reductase | 0.0228 | 1 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.0116 | 0.1326 | 0.1326 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0116 | 0.1326 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0116 | 0.1326 | 0.1326 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.1326 | 0.1326 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0228 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0116 | 0.1326 | 0.1326 |
Onchocerca volvulus | 0.0116 | 0.1326 | 1 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0116 | 0.1326 | 0.1326 |
Onchocerca volvulus | 0.0116 | 0.1326 | 1 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0116 | 0.1326 | 0.1326 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0228 | 1 | 0.5 |
Onchocerca volvulus | 0.0116 | 0.1326 | 1 | |
Toxoplasma gondii | IMP dehydrogenas | 0.0228 | 1 | 0.5 |
Onchocerca volvulus | 0.0116 | 0.1326 | 1 | |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0228 | 1 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0228 | 1 | 0.5 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0228 | 1 | 1 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0116 | 0.1326 | 0.1326 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0223 | 0.9567 | 0.9548 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0228 | 1 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0116 | 0.1326 | 0.1326 |
Onchocerca volvulus | 0.0116 | 0.1326 | 1 | |
Trypanosoma brucei | GMP reductase | 0.0228 | 1 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0124 | 0.1995 | 0.1633 |
Onchocerca volvulus | 0.0116 | 0.1326 | 1 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0116 | 0.1326 | 0.1326 |
Brugia malayi | hypothetical protein | 0.0116 | 0.1326 | 0.1326 |
Brugia malayi | SH2 domain containing protein | 0.0116 | 0.1326 | 0.1326 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0116 | 0.1326 | 0.1326 |
Brugia malayi | Protein kinase domain containing protein | 0.0116 | 0.1326 | 0.1326 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0116 | 0.1326 | 0.1326 |
Leishmania major | guanosine monophosphate reductase | 0.0228 | 1 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.0116 | 0.1326 | 0.1326 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0223 | 0.9567 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0228 | 1 | 0.5 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0228 | 1 | 1 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0228 | 1 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0228 | 1 | 1 |
Brugia malayi | SRC-1 | 0.0116 | 0.1326 | 0.1326 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0228 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 100 nM | Inhibition of Bacillus anthracis IMPDH preincubated for 10 mins before substrate addition by spectrophotometry | ChEMBL. | 25147601 |
IC50 (binding) | = 330 nM | Inhibition of Cryptosporidium IMPDH preincubated for 10 mins before substrate addition by spectrophotometry | ChEMBL. | 25147601 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.