TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 502.519 | Formula: C27H26N4O6
H donors: 5 H acceptors: 5 LogP: 3.21 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: COc1ccc(cc1)C(=O)NC(=O)Nc1ccc2c(c1)NC(=O)/C/2=C\c1[nH]c(c(c1C)CCC(=O)O)C
InChi: 1S/C27H26N4O6/c1-14-19(10-11-24(32)33)15(2)28-22(14)13-21-20-9-6-17(12-23(20)30-26(21)35)29-27(36)31-25(34)16-4-7-18(37-3)8-5-16/h4-9,12-13,28H,10-11H2,1-3H3,(H,30,35)(H,32,33)(H2,29,31,34,36)/b21-13-
InChiKey: XTXMJKTXFRAXRP-BKUYFWCQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	fms-related tyrosine kinase 3	Starlite/ChEMBL	References
Homo sapiens	aurora kinase B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Entamoeba histolytica	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania donovani	Aurora I-related kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium falciparum	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	putative protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	ko:K08850 aurora kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania major	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium knowlesi	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium vivax	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma congolense	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine kinase 12	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	Serine/threonine-protein kinase 12, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Neospora caninum	hypothetical protein	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Toxoplasma gondii	aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma cruzi	aurora B kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine-protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127024	All targets in OG5_127024
Giardia lamblia	Aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium hominis	protein kinase (EC 2.7.1.-) p46XlEg22	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium parvum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium berghei	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	aurora kinase B	303 aa	299 aa	22.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	tubulin family protein	0.0305	1	1
Brugia malayi	Dopamine receptor protein 2	0.0059	0.1418	0.1418
Echinococcus granulosus	biogenic amine 5HT receptor	0.0059	0.1418	0.1418
Brugia malayi	hypothetical protein	0.0059	0.1418	0.1418
Schistosoma mansoni	protein kinase	0.0068	0.1724	0.1724
Echinococcus multilocularis	g-protein coupled receptor	0.0059	0.1418	0.1418
Brugia malayi	AKH receptor	0.0059	0.1418	0.1418
Schistosoma mansoni	biogenic amine receptor	0.0059	0.1418	0.1418
Echinococcus multilocularis	g protein coupled receptor	0.0059	0.1418	0.1418
Loa Loa (eye worm)	tubulin beta chain	0.0305	1	1
Onchocerca volvulus		0.0059	0.1418	0.5
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0059	0.1418	0.1418
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.1418	0.1418
Trypanosoma brucei	beta tubulin	0.0305	1	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0059	0.1418	0.1418
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0059	0.1418	0.1418
Leishmania major	beta tubulin	0.0305	1	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0059	0.1418	0.1418
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.1418	0.1418
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0059	0.1418	0.1418
Loa Loa (eye worm)	tubulin beta-2A chain	0.0305	1	1
Loa Loa (eye worm)	beta-tubulin	0.0305	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.1418	0.1418
Trichomonas vaginalis	tubulin beta chain, putative	0.0305	1	1
Schistosoma mansoni	opsin-like receptor	0.0059	0.1418	0.1418
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0059	0.1418	0.1418
Brugia malayi	Dopamine receptor protein 1	0.0059	0.1418	0.1418
Leishmania major	beta tubulin	0.0305	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0305	1	1
Trypanosoma brucei	beta tubulin	0.0305	1	1
Echinococcus granulosus	serotonin receptor	0.0059	0.1418	0.1418
Loa Loa (eye worm)	G-protein coupled receptor	0.0059	0.1418	0.1418
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Leishmania major	beta tubulin	0.0305	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0059	0.1418	0.1418
Loa Loa (eye worm)	melatonin receptor type 1A	0.0059	0.1418	0.1418
Schistosoma mansoni	biogenic amine receptor	0.0059	0.1418	0.1418
Echinococcus multilocularis	fmrfamide receptor	0.0059	0.1418	0.1418
Schistosoma mansoni	neuropeptide receptor	0.0059	0.1418	0.1418
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0059	0.1418	0.1418
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0059	0.1418	0.1418
Brugia malayi	ORL1-like opioid receptor	0.0059	0.1418	0.1418
Echinococcus multilocularis	g protein coupled receptor	0.0059	0.1418	0.1418
Echinococcus granulosus	7tm_1 domain containing protein	0.0059	0.1418	0.1418
Brugia malayi	G-protein coupled receptor	0.0059	0.1418	0.1418
Echinococcus granulosus	somatostatin receptor	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Onchocerca volvulus		0.0059	0.1418	0.5
Echinococcus granulosus	beta tubulin	0.0305	1	1
Echinococcus multilocularis	allatostatin A receptor	0.0059	0.1418	0.1418
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0059	0.1418	0.1418
Plasmodium falciparum	tubulin beta chain	0.0305	1	1
Brugia malayi	serine/threonine-protein kinase 6	0.0068	0.1724	0.1724
Brugia malayi	hypothetical protein	0.0059	0.1418	0.1418
Leishmania major	beta tubulin	0.0305	1	1
Echinococcus multilocularis	serotonin receptor	0.0059	0.1418	0.1418
Brugia malayi	neuropeptide F receptor	0.0059	0.1418	0.1418
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.1418	0.1418
Brugia malayi	hypothetical protein	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Giardia lamblia	Beta tubulin	0.0305	1	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Echinococcus multilocularis	Tubulin beta 2C chain	0.0305	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.1418	0.1418
Onchocerca volvulus		0.0059	0.1418	0.5
Brugia malayi	neuropeptide F receptor	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Echinococcus multilocularis	serotonin receptor	0.0059	0.1418	0.1418
Echinococcus multilocularis	fmrfamide receptor	0.0059	0.1418	0.1418
Echinococcus granulosus	allatostatin A receptor	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Brugia malayi	Melatonin receptor type 1A	0.0059	0.1418	0.1418
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.002	0.0059	0.0059
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0059	0.1418	0.5
Schistosoma mansoni	amine GPCR	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0059	0.1418	0.1418
Echinococcus multilocularis	neuropeptide Y receptor	0.0059	0.1418	0.1418
Brugia malayi	RE15519p	0.0059	0.1418	0.1418
Schistosoma mansoni	histamine h1 receptor	0.0059	0.1418	0.1418
Onchocerca volvulus		0.0059	0.1418	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0059	0.1418	0.1418
Echinococcus granulosus	tubulin beta 1 chain	0.0305	1	1
Brugia malayi	Serotonin receptor	0.0059	0.1418	0.1418
Schistosoma mansoni	hypothetical protein	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Schistosoma mansoni	neuropeptide F-like receptor	0.0059	0.1418	0.1418
Echinococcus granulosus	tm gpcr rhodopsin	0.0059	0.1418	0.1418
Onchocerca volvulus		0.0059	0.1418	0.5
Schistosoma mansoni	tubulin subunit beta	0.0305	1	1
Toxoplasma gondii	beta-1 tubulin, putative	0.0305	1	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Echinococcus multilocularis	Tubulin beta 2C chain	0.0305	1	1
Brugia malayi	G-protein coupled receptor	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Brugia malayi	Dopamine receptor	0.0059	0.1418	0.1418
Loa Loa (eye worm)	tubulin beta-4 chain	0.0305	1	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0059	0.1418	0.1418
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.1418	0.1418
Onchocerca volvulus		0.0059	0.1418	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0059	0.1418	0.1418
Echinococcus multilocularis	aurora kinase A	0.0068	0.1724	0.1724
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Echinococcus granulosus	g protein coupled receptor	0.0059	0.1418	0.1418
Schistosoma mansoni	tubulin subunit beta	0.0305	1	1
Plasmodium vivax	tubulin beta chain, putative	0.0305	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.002	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0059	0.1418	0.1418
Leishmania major	beta tubulin	0.0305	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0305	1	1
Schistosoma mansoni	neuropeptide receptor	0.0059	0.1418	0.1418
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.1724	0.1724
Loa Loa (eye worm)	BEN-1 protein	0.0305	1	1
Schistosoma mansoni	amine GPCR	0.0059	0.1418	0.1418
Trypanosoma cruzi	beta tubulin, putative	0.0305	1	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Echinococcus granulosus	hypothetical protein	0.0059	0.1418	0.1418
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.1418	0.1418
Onchocerca volvulus		0.0059	0.1418	0.5
Echinococcus granulosus	neuropeptide s receptor	0.0059	0.1418	0.1418
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.1418	0.1418
Onchocerca volvulus		0.0059	0.1418	0.5
Echinococcus multilocularis	Tubulin beta 2C chain	0.0305	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.1418	0.1418
Echinococcus multilocularis	Tubulin beta 2C chain	0.0305	1	1
Schistosoma mansoni	neuropeptide receptor	0.0059	0.1418	0.1418
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0059	0.1418	0.1418
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0059	0.1418	0.1418
Echinococcus granulosus	7TM GPCR rhodopsin	0.0059	0.1418	0.1418
Schistosoma mansoni	tubulin subunit beta	0.0305	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0059	0.1418	0.1418
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0059	0.1418	0.1418
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Echinococcus granulosus	neuropeptide receptor A26	0.0059	0.1418	0.1418
Echinococcus multilocularis	neuropeptide s receptor	0.0059	0.1418	0.1418
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0059	0.1418	0.1418
Echinococcus granulosus	orexin receptor type 2	0.0059	0.1418	0.1418
Leishmania major	beta tubulin	0.0305	1	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0059	0.1418	0.1418
Leishmania major	beta tubulin	0.0305	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0059	0.1418	0.1418
Brugia malayi	serine/threonine protein kinase 6	0.0068	0.1724	0.1724
Brugia malayi	hypothetical protein	0.0059	0.1418	0.1418
Schistosoma mansoni	amine GPCR	0.0059	0.1418	0.1418
Loa Loa (eye worm)	G-protein coupled receptor	0.0059	0.1418	0.1418
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Echinococcus multilocularis	neuropeptide receptor A26	0.0059	0.1418	0.1418
Entamoeba histolytica	tubulin family protein	0.0305	1	1
Schistosoma mansoni	tubulin subunit beta	0.0305	1	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0059	0.1418	0.1418
Loa Loa (eye worm)	tubulin beta-1 chain	0.0305	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0305	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.1418	0.1418
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Echinococcus multilocularis	neuropeptide receptor	0.0059	0.1418	0.1418
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Leishmania major	beta tubulin	0.0305	1	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0059	0.1418	0.1418
Leishmania major	beta tubulin	0.0305	1	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0059	0.1418	0.1418
Onchocerca volvulus		0.0059	0.1418	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.1418	0.1418
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.1418	0.1418
Echinococcus multilocularis	neuropeptide receptor	0.0059	0.1418	0.1418
Schistosoma mansoni	opsin-like receptor	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.1418	0.1418
Leishmania major	beta tubulin	0.0305	1	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0059	0.1418	0.5
Leishmania major	beta tubulin	0.0305	1	1
Brugia malayi	hypothetical protein	0.0059	0.1418	0.1418
Toxoplasma gondii	beta-tubulin, putative	0.0305	1	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Leishmania major	beta tubulin	0.0305	1	1
Leishmania major	beta tubulin	0.0305	1	1
Echinococcus granulosus	sex peptide receptor	0.0059	0.1418	0.1418
Echinococcus granulosus	neuropeptides capa receptor	0.0059	0.1418	0.1418
Brugia malayi	sulfakinin receptor protein	0.0059	0.1418	0.1418
Echinococcus granulosus	Tubulin beta 2C chain	0.0305	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0305	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.1724	0.1724
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Onchocerca volvulus		0.0059	0.1418	0.5
Loa Loa (eye worm)	TYRA-2 protein	0.0059	0.1418	0.1418
Echinococcus multilocularis	beta tubulin	0.0305	1	1
Brugia malayi	GnHR receptor homolog	0.0059	0.1418	0.1418
Echinococcus granulosus	fmrfamide receptor	0.0059	0.1418	0.1418
Schistosoma mansoni	hypothetical protein	0.0059	0.1418	0.1418
Echinococcus multilocularis	dro:myosuppressin receptor	0.0059	0.1418	0.1418
Echinococcus granulosus	tubulin subunit beta	0.0305	1	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0059	0.1418	0.1418
Echinococcus granulosus	neuropeptide Y receptor	0.0059	0.1418	0.1418
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0059	0.1418	0.1418
Echinococcus granulosus	tm gpcr rhodopsin	0.0059	0.1418	0.1418
Echinococcus granulosus	Tubulin beta 2C chain	0.0305	1	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0059	0.1418	0.1418
Echinococcus multilocularis	neuropeptides capa receptor	0.0059	0.1418	0.1418
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0068	0.1724	0.1724
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.1724	0.1724
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Echinococcus granulosus	neuropeptide receptor	0.0059	0.1418	0.1418
Schistosoma mansoni	neuropeptide f receptor 76f	0.0059	0.1418	0.1418
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0059	0.1418	0.1418
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0059	0.1418	0.1418
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0059	0.1418	0.1418
Schistosoma mansoni	neuropeptide F-like receptor	0.0059	0.1418	0.1418
Leishmania major	beta tubulin	0.0305	1	1
Leishmania major	beta tubulin	0.0305	1	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Schistosoma mansoni	hypothetical protein	0.0059	0.1418	0.1418
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Schistosoma mansoni	neuropeptide receptor	0.0059	0.1418	0.1418
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0059	0.1418	0.1418
Echinococcus multilocularis	tubulin beta 1 chain	0.0305	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Schistosoma mansoni	opsin-like receptor	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Echinococcus granulosus	twitchin	0.0019	0.0019	0.0019
Schistosoma mansoni	amine GPCR	0.0059	0.1418	0.1418
Echinococcus granulosus	Tubulin beta 2C chain	0.0305	1	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0059	0.1418	0.1418
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0059	0.1418	0.1418
Brugia malayi	larval opioid receptor	0.0059	0.1418	0.1418
Giardia lamblia	Beta tubulin	0.0305	1	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Brugia malayi	hypothetical protein	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Schistosoma mansoni	biogenic amine receptor	0.0059	0.1418	0.1418
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0059	0.1418	0.1418
Brugia malayi	beta-tubulin, identical	0.0305	1	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.1418	0.1418
Loa Loa (eye worm)	BEN-1 protein	0.0305	1	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0059	0.1418	0.1418
Echinococcus granulosus	neuropeptide FF receptor 2	0.0059	0.1418	0.1418
Echinococcus multilocularis	somatostatin receptor	0.0059	0.1418	0.1418
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Brugia malayi	hypothetical protein	0.0059	0.1418	0.1418
Leishmania major	beta tubulin	0.0305	1	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0059	0.1418	0.1418
Onchocerca volvulus		0.0059	0.1418	0.5
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Brugia malayi	hypothetical protein	0.0059	0.1418	0.1418
Brugia malayi	G protein-coupled receptor	0.0059	0.1418	0.1418
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.1418	0.1418
Echinococcus multilocularis	orexin receptor type 2	0.0059	0.1418	0.1418
Echinococcus granulosus	aurora kinase A	0.0068	0.1724	0.1724
Echinococcus multilocularis	beta tubulin	0.0305	1	1
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0305	1	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Echinococcus multilocularis	neuropeptide Y receptor	0.0059	0.1418	0.1418
Loa Loa (eye worm)	neuropeptide F receptor	0.0059	0.1418	0.1418
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0059	0.1418	0.1418
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0305	1	1
Echinococcus granulosus	g protein coupled receptor	0.0059	0.1418	0.1418
Brugia malayi	serine/threonine kinase 12	0.0068	0.1724	0.1724
Toxoplasma gondii	beta tubulin	0.0305	1	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Echinococcus granulosus	dro:myosuppressin receptor	0.0059	0.1418	0.1418
Trypanosoma brucei	beta tubulin	0.0305	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.1418	0.1418
Onchocerca volvulus		0.0059	0.1418	0.5
Echinococcus granulosus	Tubulin beta 2C chain	0.0305	1	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Onchocerca volvulus		0.0059	0.1418	0.5
Schistosoma mansoni	hypothetical protein	0.0059	0.1418	0.1418
Onchocerca volvulus		0.0059	0.1418	0.5
Brugia malayi	follicle stimulating hormone receptor	0.0059	0.1418	0.1418
Echinococcus multilocularis	tubulin subunit beta	0.0305	1	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0059	0.1418	0.1418
Brugia malayi	Serotonin receptor	0.0059	0.1418	0.1418
Brugia malayi	putative neuropeptide receptor	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Echinococcus granulosus	tubulin beta 4A class IVa	0.0305	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.1418	0.1418
Schistosoma mansoni	amine GPCR	0.0059	0.1418	0.1418
Schistosoma mansoni	myosin xvIII	0.0059	0.1418	0.1418
Onchocerca volvulus		0.0059	0.1418	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0059	0.1418	0.1418
Echinococcus multilocularis	sex peptide receptor	0.0059	0.1418	0.1418
Loa Loa (eye worm)	neuropeptide F receptor	0.0059	0.1418	0.1418
Schistosoma mansoni	tubulin subunit beta	0.0305	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.1418	0.1418
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.1418	0.1418
Schistosoma mansoni	tubulin subunit beta	0.0305	1	1
Brugia malayi	hypothetical protein	0.0059	0.1418	0.1418
Trypanosoma brucei	beta tubulin	0.0305	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0059	0.1418	0.1418
Echinococcus granulosus	g-protein coupled receptor	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0059	0.1418	0.1418
Echinococcus granulosus	neuropeptide Y receptor	0.0059	0.1418	0.1418
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.1418	0.1418
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Leishmania major	beta tubulin	0.0305	1	1
Schistosoma mansoni	adenoreceptor	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Echinococcus granulosus	g protein coupled receptor	0.0059	0.1418	0.1418
Echinococcus granulosus	neuropeptide receptor	0.0059	0.1418	0.1418
Brugia malayi	G protein-coupled receptor F59B2.13	0.0059	0.1418	0.1418
Brugia malayi	hypothetical protein	0.0059	0.1418	0.1418
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0059	0.1418	0.1418
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Giardia lamblia	Beta tubulin	0.0305	1	1
Onchocerca volvulus		0.0059	0.1418	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.1418	0.1418
Leishmania major	beta tubulin	0.0305	1	1
Echinococcus granulosus	G protein coupled receptor 139	0.0059	0.1418	0.1418
Echinococcus multilocularis	g protein coupled receptor	0.0059	0.1418	0.1418
Echinococcus granulosus	beta tubulin	0.0305	1	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0059	0.1418	0.1418
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0059	0.1418	0.1418
Trichomonas vaginalis	tubulin gamma chain, putative	0.0305	1	1
Onchocerca volvulus		0.0059	0.1418	0.5
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0059	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1418	0.1418
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.1724	0.1724
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0068	0.1724	0.1724
Trichomonas vaginalis	tubulin, putative	0.0305	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.1418	0.1418

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.2 nM	Inhibition of Aurora B (unknown origin) using HLRRASLG substrate	ChEMBL.	25089810
IC50 (binding)	= 2.7 nM	Inhibition of FLT3 (unknown origin) using EAIYAAPFAKKK substrate	ChEMBL.	25089810
IC50 (functional)	= 5.3 nM	Cytotoxicity against human MV4-11 cells assessed as cell viability after 48 hrs by MTT assay	ChEMBL.	25089810

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	25089810

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3329669

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 927775