Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 32 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by MABA method | ChEMBL. | 25218911 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against extended-spectrum beta-lactamase producing Escherichia coli 12-15 after 18 to 24 hrs by standard twofold serial dilution method | ChEMBL. | 25218911 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.