Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | cathepsin L-like precursor | 0.0043 | 0.0711 | 0.075 |
Plasmodium vivax | vivapain-2 | 0.0062 | 0.2234 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0154 | 0.9471 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0062 | 0.2234 | 0.2358 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.016 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.2234 | 0.0438 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0043 | 0.0711 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0154 | 0.9471 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0113 | 0.6244 | 0.6244 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.2234 | 0.0438 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0043 | 0.0711 | 0.3182 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0062 | 0.2234 | 0.2358 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0062 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0058 | 0.1877 | 0.8406 |
Onchocerca volvulus | 0.0062 | 0.2234 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.016 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0062 | 0.2234 | 0.1738 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0062 | 0.2234 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0062 | 0.2234 | 1 |
Onchocerca volvulus | 0.0062 | 0.2234 | 1 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0062 | 0.2234 | 0.2358 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0058 | 0.1877 | 0.1877 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0062 | 0.2234 | 0.2358 |
Brugia malayi | Cathepsin L-like precursor | 0.0062 | 0.2234 | 0.2358 |
Plasmodium vivax | vivapain-2 | 0.0062 | 0.2234 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0154 | 0.9471 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.016 | 1 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0062 | 0.2234 | 0.1738 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0043 | 0.0711 | 0.075 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0062 | 0.2234 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0058 | 0.1877 | 0.1982 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0154 | 0.9471 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0062 | 0.2234 | 0.0438 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.016 | 1 | 1 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0154 | 0.9471 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0043 | 0.0711 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0062 | 0.2234 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0062 | 0.2234 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0062 | 0.2234 | 0.2358 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0062 | 0.2234 | 0.2358 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0062 | 0.2234 | 0.2358 |
Loa Loa (eye worm) | cathepsin B | 0.0058 | 0.1877 | 0.1332 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0058 | 0.1877 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.016 | 1 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0062 | 0.2234 | 0.1738 |
Loa Loa (eye worm) | ctsf protein | 0.0062 | 0.2234 | 0.1738 |
Onchocerca volvulus | 0.0062 | 0.2234 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.2234 | 0.0438 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.016 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0154 | 0.9471 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.016 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.016 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0062 | 0.2234 | 0.2358 |
Brugia malayi | Cathepsin L-like precursor | 0.0062 | 0.2234 | 0.2358 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.016 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0062 | 0.2234 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.2234 | 0.1738 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0043 | 0.0711 | 0.075 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.9471 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.016 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0043 | 0.0711 | 0.075 |
Echinococcus granulosus | cathepsin b | 0.0154 | 0.9471 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.016 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0062 | 0.2234 | 0.2358 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0154 | 0.9471 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0062 | 0.2234 | 0.2358 |
Onchocerca volvulus | 0.0062 | 0.2234 | 1 | |
Echinococcus multilocularis | cysteine protease | 0.0062 | 0.2234 | 0.2358 |
Brugia malayi | Cathepsin L-like precursor | 0.0043 | 0.0711 | 0.075 |
Leishmania major | cathepsin L-like protease | 0.016 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.016 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.016 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.016 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0043 | 0.0711 | 0.075 |
Echinococcus granulosus | cathepsin b | 0.0154 | 0.9471 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.2234 | 0.0438 |
Brugia malayi | Cathepsin L-like precursor | 0.0062 | 0.2234 | 0.2358 |
Onchocerca volvulus | 0.0062 | 0.2234 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0062 | 0.2234 | 0.2358 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.016 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0058 | 0.1877 | 0.5 |
Loa Loa (eye worm) | cysteine protease | 0.0062 | 0.2234 | 0.1738 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.2234 | 0.2234 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0062 | 0.2234 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0058 | 0.1877 | 0.5 |
Onchocerca volvulus | Cathepsin L homolog | 0.0062 | 0.2234 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0062 | 0.2234 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.016 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0062 | 0.2234 | 0.2358 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0062 | 0.2234 | 0.2358 |
Onchocerca volvulus | 0.0062 | 0.2234 | 1 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0154 | 0.9471 | 0.9471 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0062 | 0.2234 | 0.2358 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.2234 | 0.0438 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0141 | 0.8477 | 0.8477 |
Toxoplasma gondii | cathepsin CPL | 0.0062 | 0.2234 | 1 |
Onchocerca volvulus | 0.0062 | 0.2234 | 1 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0058 | 0.1877 | 0.1877 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 1 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by MABA method | ChEMBL. | 25218911 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against extended-spectrum beta-lactamase producing Escherichia coli 12-15 after 18 to 24 hrs by standard twofold serial dilution method | ChEMBL. | 25218911 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.