Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | AGC kinase | 0.0212 | 0.3573 | 0.5 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0142 | 0.175 | 0.175 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0156 | 0.2108 | 0.2108 |
Giardia lamblia | Kinase, AGC PKA | 0.0142 | 0.175 | 0.5 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0156 | 0.2108 | 0.4066 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0156 | 0.2108 | 0.2108 |
Trichomonas vaginalis | AGC family protein kinase | 0.0226 | 0.393 | 0.7582 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0212 | 0.3573 | 0.6892 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0138 | 0.1643 | 0.1643 |
Trichomonas vaginalis | AGC family protein kinase | 0.0226 | 0.393 | 0.7582 |
Trichomonas vaginalis | AGC family protein kinase | 0.0226 | 0.393 | 0.7582 |
Echinococcus granulosus | nervana 2 | 0.0138 | 0.1643 | 0.1643 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0226 | 0.393 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0226 | 0.393 | 0.7582 |
Trichomonas vaginalis | AGC family protein kinase | 0.0274 | 0.5184 | 1 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0142 | 0.175 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0153 | 0.2031 | 0.2031 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0212 | 0.3573 | 0.6892 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0142 | 0.175 | 0.175 |
Trichomonas vaginalis | AGC family protein kinase | 0.0226 | 0.393 | 0.7582 |
Echinococcus multilocularis | serotonin receptor | 0.0153 | 0.2031 | 0.2031 |
Entamoeba histolytica | protein kinase, putative | 0.0274 | 0.5184 | 1 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0142 | 0.175 | 0.175 |
Brugia malayi | Protein kinase domain containing protein | 0.0226 | 0.393 | 0.7582 |
Echinococcus granulosus | nervana 2 | 0.0138 | 0.1643 | 0.1643 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.2031 | 0.3917 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0274 | 0.5184 | 0.5184 |
Brugia malayi | Protein kinase domain containing protein | 0.0274 | 0.5184 | 1 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0226 | 0.393 | 0.7582 |
Brugia malayi | phosphoinositide-dependent protein kinase I | 0.0274 | 0.5184 | 1 |
Echinococcus multilocularis | nervana 2 | 0.0138 | 0.1643 | 0.1643 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.2031 | 0.3917 |
Entamoeba histolytica | protein kinase, putative | 0.0212 | 0.3573 | 0.6892 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0274 | 0.5184 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0156 | 0.2108 | 0.2108 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0156 | 0.2108 | 0.2108 |
Entamoeba histolytica | protein kinase 2, putative | 0.0142 | 0.175 | 0.3376 |
Echinococcus granulosus | 3-phosphoinositide-dependent protein kinase 1 | 0.0274 | 0.5184 | 0.5184 |
Trichomonas vaginalis | AGC family protein kinase | 0.0226 | 0.393 | 0.7582 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0274 | 0.5184 | 1 |
Trypanosoma cruzi | Protein kinase B | 0.0156 | 0.2108 | 1 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0138 | 0.1643 | 0.1643 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0138 | 0.1643 | 0.1643 |
Trichomonas vaginalis | AGC family protein kinase | 0.0274 | 0.5184 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0226 | 0.393 | 0.7582 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0138 | 0.1643 | 0.1643 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.046 | 1 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0156 | 0.2108 | 1 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.046 | 1 | 1 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0142 | 0.175 | 0.5 |
Echinococcus multilocularis | nervana 2 | 0.0138 | 0.1643 | 0.1643 |
Echinococcus multilocularis | serotonin receptor | 0.0153 | 0.2031 | 0.2031 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0156 | 0.2108 | 0.4066 |
Trichomonas vaginalis | AGC family protein kinase | 0.0226 | 0.393 | 0.7582 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0153 | 0.2031 | 0.2031 |
Echinococcus multilocularis | 3 phosphoinositide dependent protein kinase 1 | 0.0274 | 0.5184 | 0.5184 |
Trichomonas vaginalis | AGC family protein kinase | 0.0088 | 0.0358 | 0.069 |
Entamoeba histolytica | protein kinase, putative | 0.0226 | 0.393 | 0.7582 |
Trichomonas vaginalis | AGC family protein kinase | 0.0274 | 0.5184 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 46.83 nM | Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry | ChEMBL. | 25128671 |
Ki (binding) | = 83.33 nM | Displacement of [3H]8-OH-DPAT from human 5-HT1A receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry | ChEMBL. | 25128671 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.