TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 544.087 | Formula: C31H34ClN5O2
H donors: 3 H acceptors: 2 LogP: 4.46 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: Clc1ccc(cc1)C[C@H](C(=O)N1CCN(CC1)c1cccc2c1NCC2)NC(=O)[C@@H]1NCc2c(C1)cccc2
InChi: 1S/C31H34ClN5O2/c32-25-10-8-21(9-11-25)18-27(35-30(38)26-19-23-4-1-2-5-24(23)20-34-26)31(39)37-16-14-36(15-17-37)28-7-3-6-22-12-13-33-29(22)28/h1-11,26-27,33-34H,12-20H2,(H,35,38)/t26-,27-/m1/s1
InChiKey: NXZXDISOVUUURK-KAYWLYCHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	melanocortin 4 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0212	1	1
Schistosoma mansoni	adenoreceptor	0.0212	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0149	0.6346	1
Loa Loa (eye worm)	cathepsin B	0.0054	0.0797	0.0797
Schistosoma mansoni	amine GPCR	0.0212	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0212	1	1
Brugia malayi	Cathepsin L-like precursor	0.0058	0.104	0.104
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Echinococcus granulosus	serotonin receptor	0.0212	1	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0212	1	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0212	1	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0212	1	1
Onchocerca volvulus		0.0212	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0149	0.6346	1
Brugia malayi	hypothetical protein	0.0212	1	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Leishmania major	cathepsin L-like protease	0.0058	0.104	0.0438
Brugia malayi	hypothetical protein	0.0212	1	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0212	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0143	0.5985	0.5985
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.104	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0149	0.6346	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0058	0.104	0.104
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0212	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0058	0.104	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0212	1	1
Echinococcus granulosus	neuropeptide s receptor	0.0212	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.104	1
Echinococcus granulosus	g protein coupled receptor	0.0212	1	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0212	1	1
Onchocerca volvulus		0.0212	1	1
Schistosoma mansoni	opsin-like receptor	0.0212	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0054	0.0797	0.0797
Brugia malayi	Dopamine receptor protein 2	0.0212	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0054	0.0797	0.7662
Leishmania major	cathepsin L-like protease	0.0058	0.104	0.0438
Loa Loa (eye worm)	neuropeptide F receptor	0.0212	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0212	1	1
Onchocerca volvulus		0.0212	1	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0212	1	1
Brugia malayi	Melatonin receptor type 1A	0.0212	1	1
Echinococcus multilocularis	cathepsin b	0.0143	0.5985	0.5519
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Echinococcus granulosus	allatostatin A receptor	0.0212	1	1
Echinococcus granulosus	hypothetical protein	0.0212	1	1
Onchocerca volvulus		0.0212	1	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0149	0.6346	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0212	1	1
Echinococcus granulosus	neuropeptide receptor	0.0212	1	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0212	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Brugia malayi	RE15519p	0.0212	1	1
Echinococcus multilocularis	neuropeptide receptor	0.0212	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0212	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0212	1	1
Brugia malayi	G-protein coupled receptor	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.104	1
Brugia malayi	Papain family cysteine protease containing protein	0.0058	0.104	0.104
Brugia malayi	sulfakinin receptor protein	0.0212	1	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0212	1	1
Schistosoma mansoni	neuropeptide receptor	0.0212	1	1
Schistosoma mansoni	amine GPCR	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0212	1	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0212	1	1
Brugia malayi	larval opioid receptor	0.0212	1	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0058	0.104	0.104
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0058	0.104	1
Loa Loa (eye worm)	fibroinase	0.0058	0.104	0.104
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0149	0.6346	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0212	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0143	0.5985	0.5985
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0212	1	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0212	1	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0212	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0143	0.5985	0.9349
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0212	1	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0212	1	1
Schistosoma mansoni	amine GPCR	0.0212	1	1
Schistosoma mansoni	hypothetical protein	0.0212	1	1
Onchocerca volvulus		0.0058	0.104	0.104
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0212	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0212	1	1
Brugia malayi	AKH receptor	0.0212	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0058	0.104	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Leishmania major	cathepsin L-like protease	0.0149	0.6346	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0149	0.6346	1
Schistosoma mansoni	myosin xvIII	0.0212	1	1
Echinococcus granulosus	g-protein coupled receptor	0.0212	1	1
Loa Loa (eye worm)	cysteine protease	0.0058	0.104	0.104
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0212	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0212	1	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0212	1	1
Onchocerca volvulus		0.0212	1	1
Brugia malayi	hypothetical protein	0.0212	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0149	0.6346	1
Echinococcus granulosus	orexin receptor type 2	0.0212	1	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0212	1	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0212	1	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0105	0.378	0.5375
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Echinococcus multilocularis	orexin receptor type 2	0.0212	1	1
Brugia malayi	G protein-coupled receptor	0.0212	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0212	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.104	1
Onchocerca volvulus		0.0212	1	1
Echinococcus granulosus	fmrfamide receptor	0.0212	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.0212	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0212	1	1
Schistosoma mansoni	amine GPCR	0.0212	1	1
Leishmania major	cathepsin L-like protease	0.0058	0.104	0.0438
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0143	0.5985	0.5985
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0212	1	1
Onchocerca volvulus		0.0212	1	1
Brugia malayi	hypothetical protein	0.0212	1	1
Echinococcus granulosus	g protein coupled receptor	0.0212	1	1
Onchocerca volvulus		0.0058	0.104	0.104
Echinococcus granulosus	rhodopsin orphan GPCR	0.0212	1	1
Onchocerca volvulus		0.0058	0.104	0.104
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0149	0.6346	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0212	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.0212	1	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0212	1	1
Schistosoma mansoni	biogenic amine receptor	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0212	1	1
Schistosoma mansoni	hypothetical protein	0.0212	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0212	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0212	1	1
Schistosoma mansoni	opsin-like receptor	0.0212	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0212	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Onchocerca volvulus		0.0212	1	1
Plasmodium vivax	vivapain-2	0.0058	0.104	0.5
Echinococcus granulosus	cathepsin l1	0.0058	0.104	0.104
Brugia malayi	Dopamine receptor protein 1	0.0212	1	1
Loa Loa (eye worm)	ctsf protein	0.0058	0.104	0.104
Echinococcus granulosus	tm gpcr rhodopsin	0.0212	1	1
Onchocerca volvulus		0.0212	1	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0212	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0058	0.104	1
Giardia lamblia	Cathepsin B precursor	0.0054	0.0797	0.5
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.104	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0058	0.104	1
Echinococcus multilocularis	serotonin receptor	0.0212	1	1
Brugia malayi	Cathepsin L-like precursor	0.0058	0.104	0.104
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0212	1	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0212	1	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0212	1	1
Echinococcus multilocularis	somatostatin receptor	0.0212	1	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0212	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0212	1	1
Echinococcus granulosus	neuropeptide receptor	0.0212	1	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0212	1	1
Onchocerca volvulus		0.0212	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0058	0.104	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0058	0.104	1
Brugia malayi	Cathepsin L-like precursor	0.0058	0.104	0.104
Echinococcus granulosus	cathepsin b	0.0143	0.5985	0.5985
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0212	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0212	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.104	0.104
Brugia malayi	Serotonin receptor	0.0212	1	1
Toxoplasma gondii	cathepsin CPL	0.0058	0.104	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0212	1	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0212	1	1
Schistosoma mansoni	neuropeptide receptor	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Echinococcus granulosus	sex peptide receptor	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Brugia malayi	hypothetical protein	0.0212	1	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0212	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.104	1
Echinococcus multilocularis	allatostatin A receptor	0.0212	1	1
Brugia malayi	neuropeptide F receptor	0.0212	1	1
Schistosoma mansoni	neuropeptide receptor	0.0212	1	1
Schistosoma mansoni	neuropeptide receptor	0.0212	1	1
Brugia malayi	Cathepsin L-like precursor	0.0058	0.104	0.104
Brugia malayi	G protein-coupled receptor F59B2.13	0.0212	1	1
Brugia malayi	putative neuropeptide receptor	0.0212	1	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0212	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0149	0.6346	1
Entamoeba histolytica	cysteine proteinase, putative	0.0058	0.104	1
Echinococcus granulosus	neuropeptide receptor A26	0.0212	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0212	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.0212	1	1
Leishmania major	cathepsin L-like protease	0.0058	0.104	0.0438
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0212	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0212	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0058	0.104	1
Onchocerca volvulus		0.0058	0.104	0.104
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Schistosoma mansoni	histamine h1 receptor	0.0212	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0058	0.104	0.104
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0212	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0058	0.104	0.5
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0131	0.5306	0.8125
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0212	1	1
Brugia malayi	ORL1-like opioid receptor	0.0212	1	1
Onchocerca volvulus		0.0212	1	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0212	1	1
Onchocerca volvulus		0.0058	0.104	0.104
Brugia malayi	Cathepsin L-like precursor	0.0058	0.104	0.104
Echinococcus granulosus	neuropeptide Y receptor	0.0212	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0149	0.6346	1
Echinococcus multilocularis	serotonin receptor	0.0212	1	1
Plasmodium vivax	vivapain-2	0.0058	0.104	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0212	1	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0212	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0212	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0058	0.104	0.104
Onchocerca volvulus		0.0058	0.104	0.104
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0212	1	1
Onchocerca volvulus		0.0212	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0212	1	1
Schistosoma mansoni	opsin-like receptor	0.0212	1	1
Leishmania major	cysteine peptidase A (CPA)	0.0058	0.104	0.0438
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0212	1	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0212	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0058	0.104	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.0212	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0149	0.6346	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0212	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.104	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0058	0.104	0.104
Echinococcus multilocularis	fmrfamide receptor	0.0212	1	1
Brugia malayi	GnHR receptor homolog	0.0212	1	1
Brugia malayi	follicle stimulating hormone receptor	0.0212	1	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0212	1	1
Echinococcus granulosus	cathepsin b	0.0143	0.5985	0.5985
Echinococcus granulosus	g protein coupled receptor	0.0212	1	1
Brugia malayi	hypothetical protein	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Echinococcus multilocularis	neuropeptide s receptor	0.0212	1	1
Leishmania major	cathepsin L-like protease	0.0149	0.6346	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.104	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.104	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0212	1	1
Schistosoma mansoni	biogenic amine receptor	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Echinococcus multilocularis	neuropeptide receptor	0.0212	1	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.0143	0.5985	0.5985
Onchocerca volvulus	Cathepsin L homolog	0.0058	0.104	0.104
Onchocerca volvulus		0.0212	1	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0212	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Leishmania major	cathepsin L-like protease	0.0149	0.6346	1
Echinococcus multilocularis	g-protein coupled receptor	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0212	1	1
Onchocerca volvulus		0.0212	1	1
Echinococcus granulosus	somatostatin receptor	0.0212	1	1
Leishmania major	cathepsin L-like protease	0.0058	0.104	0.0438
Brugia malayi	Cathepsin L-like precursor	0.0058	0.104	0.104
Loa Loa (eye worm)	TYRA-2 protein	0.0212	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0058	0.104	1
Brugia malayi	Dopamine receptor	0.0212	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0212	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0149	0.6346	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.104	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0212	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0212	1	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0058	0.104	0.104
Echinococcus multilocularis	sex peptide receptor	0.0212	1	1
Giardia lamblia	Cathepsin B precursor	0.0054	0.0797	0.5
Echinococcus granulosus	G protein coupled receptor 139	0.0212	1	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0212	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0058	0.104	1
Echinococcus multilocularis	cathepsin b	0.0143	0.5985	0.5519
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0212	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0212	1	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0212	1	1
Schistosoma mansoni	hypothetical protein	0.0212	1	1
Brugia malayi	Serotonin receptor	0.0212	1	1
Brugia malayi	hypothetical protein	0.0212	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0149	0.6346	1
Onchocerca volvulus		0.0058	0.104	0.104
Schistosoma mansoni	biogenic amine receptor	0.0212	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0058	0.104	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0212	1	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0212	1	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0212	1	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0212	1	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0212	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.104	1
Onchocerca volvulus		0.0212	1	1
Onchocerca volvulus		0.0212	1	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0212	1	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0212	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0212	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0212	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0058	0.104	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0058	0.104	0.104
Echinococcus granulosus	dro:myosuppressin receptor	0.0212	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0143	0.5985	0.5985
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.104	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0212	1	1
Brugia malayi	hypothetical protein	0.0212	1	1
Loa Loa (eye worm)	hypothetical protein	0.0143	0.5985	0.5985
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0149	0.6346	1
Brugia malayi	neuropeptide F receptor	0.0212	1	1
Onchocerca volvulus	Cathepsin F homolog	0.0058	0.104	0.104
Trypanosoma cruzi	cysteine peptidase, putative	0.0149	0.6346	1
Brugia malayi	G-protein coupled receptor	0.0212	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0212	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.104	1
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Schistosoma mansoni	amine GPCR	0.0212	1	1
Giardia lamblia	Cathepsin B precursor	0.0054	0.0797	0.5
Loa Loa (eye worm)	hypothetical protein	0.0212	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0058	0.104	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0058	0.104	1
Entamoeba histolytica	cysteine protease, putative	0.0058	0.104	1
Schistosoma mansoni	hypothetical protein	0.0212	1	1
Onchocerca volvulus		0.0212	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.104	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 2.1 uM	Inhibition of [125I]-NDP MSH binding towards human melanocortin 4 receptor	ChEMBL.	16112861

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2113134

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 931953