Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 0.1352 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.0096 | 0.1352 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0096 | 0.1352 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 0.1352 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 0.1352 | 0.5 |
Leishmania major | hexokinase, putative | 0.0096 | 0.1352 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.0096 | 0.1352 | 0.5 |
Leishmania major | hexokinase, putative | 0.0096 | 0.1352 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0096 | 0.1352 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 0.1352 | 0.1352 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0292 | 1 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.0096 | 0.1352 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0292 | 1 | 1 |
Onchocerca volvulus | 0.0096 | 0.1352 | 0.5 | |
Echinococcus granulosus | hexokinase | 0.0096 | 0.1352 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.1352 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.1352 | 0.1352 |
Onchocerca volvulus | 0.0096 | 0.1352 | 0.5 | |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.1352 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0096 | 0.1352 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 0.1352 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0096 | 0.1352 | 0.5 |
Brugia malayi | hexokinase | 0.0096 | 0.1352 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.1352 | 0.1352 |
Onchocerca volvulus | 0.0096 | 0.1352 | 0.5 | |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.1352 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.0096 | 0.1352 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0096 | 0.1352 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0096 | 0.1352 | 0.5 |
Schistosoma mansoni | hexokinase | 0.0096 | 0.1352 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0096 | 0.1352 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 2120 nM | Activation of purified human glucokinase isoform 3 (13 to 466 aa) using 5 mM glucose by spectrophotometry in presence of NAD+ and glucose 6-phosphate dehydrogenase | ChEMBL. | 25203462 |
EC50 (binding) | = 2840 nM | Activation of purified human glucokinase isoform 3 (13 to 466 aa) using 5 mM glucose by spectrophotometry in presence of NAD+ and glucose 6-phosphate dehydrogenase in presence of 4% HSA | ChEMBL. | 25203462 |
Vmax (binding) | = 66 % | Activation of purified human glucokinase isoform 3 (13 to 466 aa) assessed as Vmax by spectrophotometry in presence of varying concentration of glucose relative to control | ChEMBL. | 25203462 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.