Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0104 | 0.1161 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0439 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.0946 | 0.0946 |
Loa Loa (eye worm) | hypothetical protein | 0.0439 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0104 | 0.1161 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 0.0946 | 0.0946 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0104 | 0.1161 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 0.0946 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0104 | 0.1161 | 1 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0104 | 0.1161 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0104 | 0.1161 | 0.1161 |
Onchocerca volvulus | 0.0096 | 0.0946 | 1 | |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0104 | 0.1161 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.0946 | 0.0946 |
Onchocerca volvulus | 0.0096 | 0.0946 | 1 | |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0104 | 0.1161 | 1 |
Schistosoma mansoni | hexokinase | 0.0096 | 0.0946 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0104 | 0.1161 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0104 | 0.1161 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0104 | 0.1161 | 1 |
Brugia malayi | Hexokinase family protein | 0.0096 | 0.0946 | 0.8146 |
Treponema pallidum | hexokinase (hxk) | 0.0096 | 0.0946 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0096 | 0.0946 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0139 | 0.0139 |
Brugia malayi | P38 map kinase family protein 2 | 0.0104 | 0.1161 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0439 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0439 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.0096 | 0.0946 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 0.0946 | 0.5 |
Brugia malayi | hexokinase | 0.0096 | 0.0946 | 0.8146 |
Onchocerca volvulus | 0.0096 | 0.0946 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 132 nM | Activation of purified human glucokinase isoform 3 (13 to 466 aa) using 5 mM glucose by spectrophotometry in presence of NAD+ and glucose 6-phosphate dehydrogenase | ChEMBL. | 25203462 |
EC50 (binding) | = 550 nM | Activation of purified human glucokinase isoform 3 (13 to 466 aa) using 5 mM glucose by spectrophotometry in presence of NAD+ and glucose 6-phosphate dehydrogenase in presence of 4% HSA | ChEMBL. | 25203462 |
ERH (ADMET) | = 95 % | Extraction ratio in human liver microsomes at 1 uM up to 20 mins by LC-MS/MS analysis | ChEMBL. | 25203462 |
Vmax (binding) | = 75 % | Activation of purified human glucokinase isoform 3 (13 to 466 aa) assessed as Vmax by spectrophotometry in presence of varying concentration of glucose relative to control | ChEMBL. | 25203462 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.