Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0096 | 1 | 0.5 |
Toxoplasma gondii | hexokinase | 0.0096 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0096 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 1 | 1 |
Schistosoma mansoni | hexokinase | 0.0096 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.006 | 0.4537 | 0.4537 |
Trypanosoma brucei | hexokinase, putative | 0.0096 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0096 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0096 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0096 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.0096 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.0096 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.0096 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 1 | 1 |
Onchocerca volvulus | 0.0096 | 1 | 1 | |
Onchocerca volvulus | 0.0096 | 1 | 1 | |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.5339 | 0.5339 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.0096 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.006 | 0.4537 | 0.4537 |
Trypanosoma brucei | hexokinase | 0.0096 | 1 | 0.5 |
Onchocerca volvulus | 0.0096 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 111 nM | Activation of purified human glucokinase isoform 3 (13 to 466 aa) using 5 mM glucose by spectrophotometry in presence of NAD+ and glucose 6-phosphate dehydrogenase | ChEMBL. | 25203462 |
EC50 (binding) | = 196 nM | Activation of purified human glucokinase isoform 3 (13 to 466 aa) using 5 mM glucose by spectrophotometry in presence of NAD+ and glucose 6-phosphate dehydrogenase in presence of 4% HSA | ChEMBL. | 25203462 |
ERH (ADMET) | = 44 % | Extraction ratio in human liver microsomes at 1 uM up to 20 mins by LC-MS/MS analysis | ChEMBL. | 25203462 |
Vmax (binding) | = 59 % | Activation of purified human glucokinase isoform 3 (13 to 466 aa) assessed as Vmax by spectrophotometry in presence of varying concentration of glucose relative to control | ChEMBL. | 25203462 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.