Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase N1 | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, theta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, eta | Starlite/ChEMBL | References |
Homo sapiens | Rho-associated, coiled-coil containing protein kinase 2 | Starlite/ChEMBL | References |
Homo sapiens | Rho-associated, coiled-coil containing protein kinase 1 | Starlite/ChEMBL | References |
Homo sapiens | protein kinase N2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0498 | 0.4195 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.1412 | 0.0652 |
Echinococcus granulosus | rho-associated protein kinase 1 | 0.0353 | 0.2778 | 0.971 |
Onchocerca volvulus | 0.0213 | 0.1412 | 0.1384 | |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.2123 | 0.1427 |
Brugia malayi | Hr1 repeat family protein | 0.0361 | 0.2861 | 0.223 |
Brugia malayi | LBP/BPI | 0.0213 | 0.1412 | 0.0652 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0286 | 0.2123 | 0.1427 |
Onchocerca volvulus | 0.0498 | 0.4195 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.2123 | 0.1427 |
Onchocerca volvulus | 0.0498 | 0.4195 | 1 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0286 | 0.2123 | 0.1427 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0965 | 0.0166 |
Onchocerca volvulus | 0.0351 | 0.2761 | 0.5559 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0213 | 0.1412 | 0.5 |
Brugia malayi | hypothetical protein | 0.0286 | 0.2123 | 0.1427 |
Onchocerca volvulus | 0.0353 | 0.2778 | 0.5614 | |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.1412 | 0.0652 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0353 | 0.2778 | 0.971 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0151 | 0.0812 | 0.2839 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0133 | 0.0638 | 0.2228 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0286 | 0.2123 | 0.1427 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.1093 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.2123 | 0.1427 |
Loa Loa (eye worm) | hypothetical protein | 0.0498 | 0.4195 | 0.3682 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0965 | 0.0166 |
Onchocerca volvulus | 0.0498 | 0.4195 | 1 | |
Onchocerca volvulus | 0.0498 | 0.4195 | 1 | |
Onchocerca volvulus | 0.0498 | 0.4195 | 1 | |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0085 | 0.017 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0361 | 0.2861 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0151 | 0.0812 | 0.2839 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.145 | 0.0694 |
Onchocerca volvulus | 0.0286 | 0.2123 | 0.3586 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0498 | 0.4195 | 0.3682 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.1125 | 0.034 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0361 | 0.2861 | 1 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0498 | 0.4195 | 0.3682 |
Onchocerca volvulus | 0.0498 | 0.4195 | 1 | |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0311 | 0.2376 | 0.8304 |
Brugia malayi | Fes/CIP4 homology domain containing protein | 0.0172 | 0.1021 | 0.0227 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.2123 | 0.1427 |
Loa Loa (eye worm) | thyroid receptor interactor | 0.0172 | 0.1021 | 0.0227 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0361 | 0.2861 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0311 | 0.2376 | 0.8304 |
Onchocerca volvulus | 0.0498 | 0.4195 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0965 | 0.0166 |
Brugia malayi | hypothetical protein | 0.0286 | 0.2123 | 0.1427 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.1412 | 0.0652 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0085 | 0.017 | 0.0593 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0286 | 0.2123 | 0.1427 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0498 | 0.4195 | 0.3682 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.2123 | 0.1427 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.1412 | 0.0652 |
Echinococcus multilocularis | rho associated protein kinase | 0.0353 | 0.2778 | 0.971 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0286 | 0.2123 | 0.1427 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0361 | 0.2861 | 0.223 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0151 | 0.0812 | 0.2839 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0498 | 0.4195 | 0.3682 |
Onchocerca volvulus | 0.0286 | 0.2123 | 0.3586 | |
Brugia malayi | hypothetical protein | 0.0213 | 0.1412 | 0.0652 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 100 nM | Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysis | ChEMBL. | 25248678 |
IC50 (binding) | = 233 nM | Inhibition of ROCK-1 (unknown origin) | ChEMBL. | 25248678 |
IC50 (binding) | > 1000 nM | Inhibition of PKN-1 (unknown origin) | ChEMBL. | 25248678 |
IC50 (binding) | > 1000 nM | Inhibition of human recombinant PKN-2 using AKRRRLSSLRA as substrate after 40 mins by scintillation counting analysis | ChEMBL. | 25248678 |
IC50 (binding) | > 1000 nM | Inhibition of human recombinant PKC-eta after 60 mins by 33P-ATP incorporation assay | ChEMBL. | 25248678 |
IC50 (binding) | > 1000 nM | Inhibition of human recombinant PKC-theta after 60 mins by 33P-ATP incorporation assay | ChEMBL. | 25248678 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.