Detailed view for EgrG_000108900

Basic information

TDR Targets ID: 583164
Echinococcus granulosus, serine:threonine protein kinase N2
Source Database / ID:  GeneDB

pI: 8.0445 | Length (AA): 109 | MW (Da): 12181 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02185   Hr1 repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0007165   signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
10 83 2rmk (B) 122 198 35.00 0 0.99 1.2284 -1.49

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130229)

Species Accession Gene Product
Brugia malayi Bm1_26205   Hr1 repeat family protein
Caenorhabditis elegans CELE_F46F6.2   Protein PKN-1, isoform B
Drosophila melanogaster Dmel_CG2049   Protein kinase related to protein kinase N
Echinococcus granulosus EgrG_000109100   serine:threonine protein kinase N2
Echinococcus granulosus EgrG_000108900   serine:threonine protein kinase N2
Echinococcus multilocularis EmuJ_000108900   serine:threonine protein kinase N2
Echinococcus multilocularis EmuJ_000109100   serine:threonine protein kinase N2
Homo sapiens ENSG00000123143   protein kinase N1
Homo sapiens ENSG00000065243   protein kinase N2
Homo sapiens ENSG00000160447   protein kinase N3
Loa Loa (eye worm) LOAG_03554   AGC/PKN protein kinase
Mus musculus ENSMUSG00000026785   protein kinase N3
Mus musculus ENSMUSG00000004591   protein kinase N2
Mus musculus ENSMUSG00000057672   protein kinase N1
Schistosoma japonicum Sjp_0312450   expressed protein
Schistosoma japonicum Sjp_0062820   Serine/threonine-protein kinase N1, putative
Schistosoma japonicum Sjp_0122880   IPR000961,Protein kinase, C-terminal,domain-containing
Schistosoma japonicum Sjp_0078160   Serine/threonine-protein kinase N2, putative
Schistosoma mansoni Smp_160760   serine/threonine protein kinase
Schmidtea mediterranea mk4.002307.02   Serine/threonine-protein kinase N
Schmidtea mediterranea mk4.002813.00   Serine/threonine-protein kinase sgk-1
Schmidtea mediterranea mk4.001316.11   Serine/threonine-protein kinase N

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens protein kinase N2 Compounds References
Homo sapiens protein kinase N1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0156 0.2676 0.4837
0.0311 0.3693 0.3693
0.0291 0.3622 0.3609
0.0311 0.4251 0.4251
0.0285 0.3042 0.3042
0.0311 0.4205 0.4201
0.0156 0.2517 0.2515
0.0822 0.2822 0.8604
0.0311 0.3693 0.3693
0.0311 0.2729 0.3607
0.0265 0.2755 0.392
0.0311 0.4203 0.4188
0.0311 0.2896 0.4195
0.0291 0.262 0.3609
0.0142 0.2531 0.8488
0.0289 0.3614 0.3609
0.0311 0.2727 0.7767
0.03 0.3596 0.359
0.0311 0.2729 0.3607
0.0217 0.3603 0.359
0.0263 0.2905 0.3598
0.0503 0.2802 0.3529
0.0236 0.2642 0.3674
0.0538 0.276 0.8563
0.0138098 0.31112 0.862186
0.0311 0.2729 0.3607
0.0156 0.2719 0.4306
0.0146 0.2665 0.8484
0.0144 0.2538 0.8484
0.0268 0.2504 0.8469
0.0311 0.5974 0.8388
0.0276 0.3603 0.359
0.0529 0.2566 0.3731
0.0581 0.4203 0.4186
0.0555 0.3618 0.3616
0.0226 0.2575 0.2702
0.0516 0.4184 0.4184
0.0311 0.3693 0.3693
0.0262 0.2867 0.2908
0.0711 0.3212 0.3212
0.0253 0.2839 0.2839
0.0128 0.2624 0.8549
0.0788 0.2727 0.8549
0.0156 0.4593 0.465
0.0277 0.3019 0.3019
0.0263 0.2905 0.3598
0.052 0.422 0.4193
0.0311 0.2823 0.392
0.0704 0.2618 0.2618
0.0707 0.2948 0.2948
0.0311 0.4251 0.4251
0.0261 0.2727 0.8549
0.0238 0.2654 0.3699
0.0208 0.2741 0.4252
0.0292 0.3596 0.359
0.0818 0.2823 0.3978
0.051 0.2568 0.2559
0.0287 0.2538 0.8484
0.0311 0.2729 0.3607
0.0261 0.2917 0.3357
0.0127 0.2538 0.5069

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier EgrG_000108900 (Echinococcus granulosus), serine:threonine protein kinase N2
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