Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Synaptic vesicular amine transporter | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Synaptic vesicular amine transporter, putative | Get druggable targets OG5_129780 | All targets in OG5_129780 |
Loa Loa (eye worm) | abnormal catecholamine distribution protein 1 | Get druggable targets OG5_129780 | All targets in OG5_129780 |
Brugia malayi | Abnormal catecholamine distribution protein 1 | Get druggable targets OG5_129780 | All targets in OG5_129780 |
Schistosoma mansoni | vesicular amine transporter | Get druggable targets OG5_129780 | All targets in OG5_129780 |
Echinococcus granulosus | synaptic vesicular amine transporter | Get druggable targets OG5_129780 | All targets in OG5_129780 |
Schistosoma japonicum | Synaptic vesicular amine transporter, putative | Get druggable targets OG5_129780 | All targets in OG5_129780 |
Echinococcus multilocularis | synaptic vesicular amine transporter | Get druggable targets OG5_129780 | All targets in OG5_129780 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | vesicular acetylcholine transporter | Synaptic vesicular amine transporter | 515 aa | 477 aa | 37.7 % |
Onchocerca volvulus | Synaptic vesicular amine transporter | 515 aa | 447 aa | 51.9 % | |
Brugia malayi | vesicular acetylcholine transporter unc-17 | Synaptic vesicular amine transporter | 515 aa | 471 aa | 38.0 % |
Echinococcus multilocularis | vesicular acetylcholine transporter | Synaptic vesicular amine transporter | 515 aa | 463 aa | 36.5 % |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | Synaptic vesicular amine transporter | 515 aa | 471 aa | 37.8 % |
Schistosoma japonicum | ko:K08155 MFS transporter, DHA1 family, solute carrier family 18 (vesicular, putative | Synaptic vesicular amine transporter | 515 aa | 472 aa | 38.8 % |
Echinococcus granulosus | vesicular acetylcholine transporter | Synaptic vesicular amine transporter | 515 aa | 463 aa | 36.7 % |
Onchocerca volvulus | Synaptic vesicular amine transporter | 515 aa | 476 aa | 37.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0843 | 0.2247 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0719 | 0.1871 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0719 | 0.1871 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0719 | 0.1871 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0719 | 0.1871 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0719 | 0.1871 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0719 | 0.1871 | 0.5 |
Echinococcus multilocularis | synaptic vesicular amine transporter | 0.0228 | 0.0381 | 0.1696 |
Brugia malayi | Abnormal catecholamine distribution protein 1 | 0.0228 | 0.0381 | 0.1696 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0102 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0719 | 0.1871 | 0.1871 |
Plasmodium vivax | PST-A protein | 0.0719 | 0.1871 | 1 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0761 | 0.1998 | 0.1998 |
Leishmania major | monoglyceride lipase, putative | 0.0719 | 0.1871 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0719 | 0.1871 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0843 | 0.2247 | 1 |
Loa Loa (eye worm) | abnormal catecholamine distribution protein 1 | 0.0228 | 0.0381 | 0.1696 |
Echinococcus granulosus | synaptic vesicular amine transporter | 0.0228 | 0.0381 | 0.1696 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0719 | 0.1871 | 0.5 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0761 | 0.1998 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0719 | 0.1871 | 0.5 |
Mycobacterium ulcerans | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD | 0.3402 | 1 | 1 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0102 | 0 | 0.5 |
Plasmodium falciparum | esterase, putative | 0.0719 | 0.1871 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0719 | 0.1871 | 1 |
Mycobacterium ulcerans | lysophospholipase | 0.0719 | 0.1871 | 0.1871 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0719 | 0.1871 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0719 | 0.1871 | 1 |
Schistosoma mansoni | vesicular amine transporter | 0.0228 | 0.0381 | 0.1696 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0102 | 0 | 0.5 |
Schistosoma mansoni | amidase | 0.0843 | 0.2247 | 1 |
Brugia malayi | amidase | 0.0843 | 0.2247 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0843 | 0.2247 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0843 | 0.2247 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0843 | 0.2247 | 1 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0719 | 0.1871 | 0.5 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0843 | 0.2247 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0719 | 0.1871 | 0.5 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0719 | 0.1871 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0719 | 0.1871 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.98 nM | Displacement of [125I]-iodovinyl-TBZ from VMAT2 in rat striatal homogenate after 60 mins by gamma counting | ChEMBL. | 21531556 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.