TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 413.289 | Formula: C15H17BrN4O3S
H donors: 3 H acceptors: 5 LogP: 2.18 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: ONC(=O)CCCCCC(=O)Nc1nnc(s1)c1ccc(cc1)Br
InChi: 1S/C15H17BrN4O3S/c16-11-8-6-10(7-9-11)14-18-19-15(24-14)17-12(21)4-2-1-3-5-13(22)20-23/h6-9,23H,1-5H2,(H,20,22)(H,17,19,21)
InChiKey: UTSZPPPVQZFVKN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	histone deacetylase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742
Entamoeba histolytica	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Theileria parva	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Giardia lamblia	Histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742
Cryptosporidium parvum	histone deacetylase HDA2/Rpd3p	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania major	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania braziliensis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania infantum	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Echinococcus multilocularis	histone deacetylase 1	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Loa Loa (eye worm)	histone deacetylase 3	Get druggable targets OG5_126742	All targets in OG5_126742
Cryptosporidium hominis	histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126742	All targets in OG5_126742
Plasmodium falciparum	histone deacetylase 1	Get druggable targets OG5_126742	All targets in OG5_126742
Plasmodium knowlesi	histone deacetylase 1, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Neospora caninum	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Echinococcus granulosus	histone deacetylase 1	Get druggable targets OG5_126742	All targets in OG5_126742
Trypanosoma brucei gambiense	histone deacetylase 1,histone deacetylase-like 1 protein, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Plasmodium vivax	histone deacetylase 1, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Candida albicans	one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component	Get druggable targets OG5_126742	All targets in OG5_126742
Trypanosoma brucei	histone deacetylase 1	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania mexicana	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Trypanosoma congolense	histone deacetylase-like 1 protein, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Schistosoma mansoni	histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania donovani	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania mexicana	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Plasmodium berghei	histone deacetylase 1, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Echinococcus multilocularis	histone deacetylase 3	Get druggable targets OG5_126742	All targets in OG5_126742
Loa Loa (eye worm)	histone deacetylase 1	Get druggable targets OG5_126742	All targets in OG5_126742
Candida albicans	one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania infantum	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania donovani	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Brugia malayi	Histone deacetylase 1	Get druggable targets OG5_126742	All targets in OG5_126742
Neospora caninum	hypothetical protein	Get druggable targets OG5_126742	All targets in OG5_126742
Trypanosoma cruzi	histone deacetylase 1, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Babesia bovis	histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742
Cryptosporidium parvum	RPD3/HD1 histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742
Candida albicans	one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component	Get druggable targets OG5_126742	All targets in OG5_126742
Toxoplasma gondii	histone deacetylase HDAC3	Get druggable targets OG5_126742	All targets in OG5_126742
Brugia malayi	histone deacetylase 3 (HD3)	Get druggable targets OG5_126742	All targets in OG5_126742
Brugia malayi	histone deacetylase 1 (HD1)	Get druggable targets OG5_126742	All targets in OG5_126742
Candida albicans	one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania braziliensis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Cryptosporidium hominis	histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania major	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Schistosoma japonicum	ko:K06067 histone deacetylase 1/2, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Toxoplasma gondii	histone deacetylase HDAC2	Get druggable targets OG5_126742	All targets in OG5_126742
Plasmodium yoelii	histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Trypanosoma cruzi	histone deacetylase 1, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Echinococcus granulosus	histone deacetylase 3	Get druggable targets OG5_126742	All targets in OG5_126742
Schistosoma japonicum	ko:K01463 Hdac3 [EC:3.5.1.-], putative	Get druggable targets OG5_126742	All targets in OG5_126742

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.086	0.3201
Schistosoma mansoni	cathepsin F (C01 family)	0.0111	0.086	0.086
Onchocerca volvulus		0.0111	0.086	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.086	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0111	0.086	0.3201
Leishmania major	cathepsin L-like protease	0.0111	0.086	0.2629
Leishmania major	cathepsin L-like protease	0.0111	0.086	0.2629
Plasmodium falciparum	histone deacetylase 1	0.0077	0.0209	0.2425
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0596	1	1
Brugia malayi	Cathepsin L-like precursor	0.008	0.0274	0.0274
Entamoeba histolytica	cysteine protease, putative	0.0111	0.086	1
Entamoeba histolytica	cysteine proteinase, putative	0.0111	0.086	1
Echinococcus granulosus	histone deacetylase 3	0.0077	0.0209	0.0209
Schistosoma mansoni	tyrosinase precursor	0.0094	0.0532	0.0532
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.086	0.3201
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.086	0.3201
Brugia malayi	histone deacetylase 1 (HD1)	0.0077	0.0209	0.0209
Giardia lamblia	Cathepsin B precursor	0.0208	0.2688	1
Trypanosoma cruzi	histone deacetylase 1, putative	0.0077	0.0209	0.0209
Toxoplasma gondii	cathepsin CPL	0.0111	0.086	0.2629
Onchocerca volvulus	Cathepsin L homolog	0.0111	0.086	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.086	0.3201
Brugia malayi	Common central domain of tyrosinase family protein	0.0094	0.0532	0.0532
Loa Loa (eye worm)	ShTK domain-containing protein	0.0094	0.0532	0.033
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.086	0.3201
Toxoplasma gondii	cathepsin B	0.0208	0.2688	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0111	0.086	0.086
Trypanosoma cruzi	cysteine peptidase, putative	0.0111	0.086	0.086
Schistosoma mansoni	cathepsin F (C01 family)	0.008	0.0274	0.0274
Loa Loa (eye worm)	tyrosinase 1	0.0094	0.0532	0.033
Leishmania major	cathepsin L-like protease	0.0111	0.086	0.2629
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.008	0.0274	0.1018
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0208	0.2688	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.0274	0.0067
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.086	0.3201
Brugia malayi	Papain family cysteine protease containing protein	0.0111	0.086	0.086
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0111	0.086	0.0666
Brugia malayi	Cathepsin L-like precursor	0.0111	0.086	0.086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.086	0.3201
Brugia malayi	Cathepsin L-like precursor	0.0111	0.086	0.086
Giardia lamblia	Cathepsin B precursor	0.0208	0.2688	1
Brugia malayi	Histone deacetylase 1	0.0077	0.0209	0.0209
Loa Loa (eye worm)	ShTK domain-containing protein	0.0094	0.0532	0.033
Trichomonas vaginalis	histone deacetylase, putative	0.0077	0.0209	0.0776
Onchocerca volvulus		0.0111	0.086	1
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0077	0.0209	0.0776
Leishmania major	cathepsin L-like protease	0.0111	0.086	0.2629
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.086	0.3201
Echinococcus granulosus	cathepsin b	0.0596	1	1
Onchocerca volvulus	Cathepsin F homolog	0.0111	0.086	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.086	0.3201
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.086	0.3201
Plasmodium vivax	histone deacetylase 1, putative	0.0077	0.0209	0.2425
Onchocerca volvulus		0.0111	0.086	1
Schistosoma mansoni	histone deacetylase	0.0077	0.0209	0.0209
Schistosoma mansoni	cathepsin F (C01 family)	0.0111	0.086	0.086
Echinococcus multilocularis	cathepsin L cysteine protease	0.0111	0.086	0.086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.086	0.3201
Brugia malayi	cathepsin L-like precursor	0.008	0.0274	0.0274
Echinococcus multilocularis	cathepsin L cysteine protease	0.0111	0.086	0.086
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0208	0.2688	0.2688
Brugia malayi	Cathepsin L-like precursor	0.0111	0.086	0.086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.086	0.3201
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0111	0.086	0.0666
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.008	0.0274	0.0274
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.086	0.3201
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0111	0.086	1
Echinococcus granulosus	cathepsin b	0.0596	1	1
Loa Loa (eye worm)	hypothetical protein	0.0111	0.086	0.0666
Trypanosoma cruzi	histone deacetylase 1, putative	0.0077	0.0209	0.0209
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0077	0.0209	0.0776
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.086	0.3201
Entamoeba histolytica	cysteine proteinase, putative	0.008	0.0274	0.3182
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0596	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0596	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0596	1	1
Entamoeba histolytica	histone deacetylase, putative	0.0077	0.0209	0.2425
Loa Loa (eye worm)	hypothetical protein	0.008	0.0274	0.0067
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.086	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.086	0.3201
Onchocerca volvulus		0.0111	0.086	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.086	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.008	0.0274	0.1018
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0532	0.033
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0094	0.0532	0.0532
Brugia malayi	Cathepsin L-like cysteine proteinase	0.008	0.0274	0.0274
Loa Loa (eye worm)	fibroinase	0.0111	0.086	0.0666
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.086	0.3201
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.086	0.3201
Loa Loa (eye worm)	cysteine protease	0.0111	0.086	0.0666
Echinococcus granulosus	cathepsin l1	0.0111	0.086	0.086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.086	0.3201
Plasmodium vivax	vivapain-2	0.0111	0.086	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0111	0.086	0.086
Giardia lamblia	Cathepsin B precursor	0.0208	0.2688	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0111	0.086	0.086
Onchocerca volvulus		0.0111	0.086	1
Trichomonas vaginalis	histone deacetylase, putative	0.0077	0.0209	0.0776
Brugia malayi	Cathepsin L-like precursor	0.0111	0.086	0.086
Brugia malayi	histone deacetylase 3 (HD3)	0.0077	0.0209	0.0209
Onchocerca volvulus		0.0111	0.086	1
Loa Loa (eye worm)	cathepsin B	0.0208	0.2688	0.2532
Onchocerca volvulus		0.0094	0.0532	0.4402
Leishmania major	cathepsin L-like protease	0.0111	0.086	0.2629
Onchocerca volvulus	Cathepsin L homolog	0.0111	0.086	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.086	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.086	0.3201
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0111	0.086	1
Onchocerca volvulus		0.0111	0.086	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0111	0.086	0.086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.086	0.3201
Trichomonas vaginalis	histone deacetylase, putative	0.0077	0.0209	0.0776
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0094	0.0532	0.0532
Leishmania major	cathepsin L-like protease	0.0111	0.086	0.2629
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0111	0.086	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.086	0.3201
Onchocerca volvulus		0.0094	0.0532	0.4402
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0094	0.0532	0.0532
Leishmania major	cathepsin L-like protease	0.0111	0.086	0.2629
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0111	0.086	0.086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.086	0.3201
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0094	0.0532	0.0532
Echinococcus multilocularis	cysteine protease	0.0111	0.086	0.086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0111	0.086	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.086	0.3201
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0077	0.0209	0.0776
Entamoeba histolytica	cysteine proteinase, putative	0.0111	0.086	1
Trichomonas vaginalis	histone deacetylase, putative	0.0077	0.0209	0.0776
Trichomonas vaginalis	histone deacetylase, putative	0.0077	0.0209	0.0776
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.086	0.3201
Trypanosoma cruzi	cruzipain precursor, putative	0.0111	0.086	0.086
Loa Loa (eye worm)	ctsf protein	0.0111	0.086	0.0666
Brugia malayi	Cathepsin L-like precursor	0.0111	0.086	0.086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.086	0.3201
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0208	0.2688	1
Onchocerca volvulus		0.0094	0.0532	0.4402
Trichomonas vaginalis	histone deacetylase, putative	0.0077	0.0209	0.0776
Trypanosoma cruzi	cysteine peptidase, putative	0.0111	0.086	0.086
Echinococcus multilocularis	histone deacetylase 3	0.0077	0.0209	0.0209
Trypanosoma brucei	histone deacetylase 1	0.0077	0.0209	0.0776
Schistosoma mansoni	tyrosinase precursor	0.0094	0.0532	0.0532
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.086	0.3201
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0111	0.086	0.086
Brugia malayi	Cathepsin L-like precursor	0.0111	0.086	0.086
Echinococcus multilocularis	histone deacetylase 1	0.0077	0.0209	0.0209
Echinococcus granulosus	histone deacetylase 1	0.0077	0.0209	0.0209
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0208	0.2688	1
Plasmodium vivax	vivapain-2	0.0111	0.086	1
Onchocerca volvulus		0.0094	0.0532	0.4402
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.086	0.3201
Echinococcus multilocularis	cysteine protease	0.0111	0.086	0.086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.086	0.3201
Schistosoma mansoni	histone deacetylase	0.0077	0.0209	0.0209
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.086	0.3201
Brugia malayi	ShTK domain containing protein	0.0094	0.0532	0.0532
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0596	1	1
Echinococcus granulosus	cathepsin l1	0.008	0.0274	0.0274
Echinococcus multilocularis	cathepsin b	0.0596	1	1
Brugia malayi	Cathepsin L-like precursor	0.008	0.0274	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0596	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.086	0.3201
Leishmania major	cysteine peptidase A (CPA)	0.0111	0.086	0.2629
Loa Loa (eye worm)	hypothetical protein	0.008	0.0274	0.0067
Echinococcus multilocularis	cathepsin b	0.0596	1	1
Leishmania major	cathepsin L-like protease	0.0111	0.086	0.2629
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0532	0.033
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0208	0.2688	0.2688

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1285 nM	Inhibition of HDAC1/HDAC2 in human HeLa cell extract incubated for 5 mins prior to substrate addition measured after 30 mins by microtitre plate reader analysis	ChEMBL.	25311567

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3341762

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 934585