Detailed information for compound 934737

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 503.424 | Formula: C22H16Cl2N4O2S2
  • H donors: 1 H acceptors: 3 LogP: 5.63 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1ccc(cc1)C1CC(=NN1c1nc2c(s1)cc(cc2)S(=O)(=O)N)c1ccc(cc1)Cl
  • InChi: 1S/C22H16Cl2N4O2S2/c23-15-5-1-13(2-6-15)19-12-20(14-3-7-16(24)8-4-14)28(27-19)22-26-18-10-9-17(32(25,29)30)11-21(18)31-22/h1-11,20H,12H2,(H2,25,29,30)
  • InChiKey: XNFHKWPHHDIKDS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus transient receptor potential cation channel 0.0027 0.0143 0.0143
Brugia malayi voltage-dependent calcium channel 0.0027 0.0143 0.0143
Echinococcus granulosus voltage dependent calcium channel 0.0651 1 1
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0227 0.3295 1
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0143 0.0143
Loa Loa (eye worm) voltage-gated calcium channel 0.0027 0.0143 0.0143
Echinococcus granulosus sodium and chloride dependent glycine 0.008 0.0981 0.0981
Echinococcus granulosus potassium voltage gated channel protein 0.0027 0.0143 0.0143
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0027 0.0143 0.0143
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0027 0.0143 1
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0027 0.0143 0.0143
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0414 0.0414
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.0143
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0027 0.0143 0.5
Echinococcus multilocularis sodium and chloride dependent glycine 0.008 0.0981 0.0981
Echinococcus granulosus two pore calcium channel protein 1 0.0027 0.0143 0.0143
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0414 0.0414
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0027 0.0143 0.0143
Echinococcus multilocularis transient receptor potential cation channel 0.0027 0.0143 0.0143
Echinococcus multilocularis ryanodine receptor 44f 0.0027 0.0143 0.0143
Schistosoma mansoni voltage-gated cation channel 0.0651 1 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0027 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.0143
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0143 0.0143
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0143 0.0143
Echinococcus granulosus transient receptor potential cation channel 0.0027 0.0143 0.0143
Echinococcus granulosus voltage gated potassium channel 0.0027 0.0143 0.0143
Onchocerca volvulus 0.0027 0.0143 0.5
Schistosoma mansoni sodium/chloride dependent transporter 0.008 0.0981 0.0981
Echinococcus multilocularis high voltage activated calcium channel beta 0.0146 0.2023 0.2023
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.0143
Echinococcus granulosus transient receptor potential cation channel 0.0027 0.0143 0.0143
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0027 0.0143 0.0143
Echinococcus multilocularis sodium channel protein 0.0027 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.0143
Leishmania major hypothetical protein, unknown function 0.0027 0.0143 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0027 0.0143 0.0143
Brugia malayi Transient-receptor-potential like protein 0.0027 0.0143 0.0143
Toxoplasma gondii hypothetical protein 0.0027 0.0143 0.0435
Echinococcus granulosus ryanodine receptor 44f 0.0027 0.0143 0.0143
Loa Loa (eye worm) voltage-dependent calcium channel 0.0227 0.3295 0.3295
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0027 0.0143 0.0143
Echinococcus multilocularis potassium voltage gated channel protein 0.0027 0.0143 0.0143
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0027 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0048 0.0477 0.0477
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.0143
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0143 0.0143
Schistosoma mansoni transient receptor potential channel 0.0027 0.0143 0.0143
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0027 0.0143 0.0143
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0027 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.0143
Loa Loa (eye worm) ion channel NompC 0.0027 0.0143 0.0143
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0651 1 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0 0.5
Schistosoma mansoni ryanodine receptor related 0.0027 0.0143 0.0143
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0027 0.0143 0.0143
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.0143 0.0143
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0027 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.0143
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0027 0.0143 0.0143
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0027 0.0143 0.0143
Schistosoma mansoni voltage-gated ion channel 0.0027 0.0143 0.0143
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.0143 0.0143
Schistosoma mansoni 60S ribosomal protein L21 0.0027 0.0143 0.0143
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.0143 0.0143
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0227 0.3295 1
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0027 0.0143 0.0143
Echinococcus granulosus short transient receptor potential channel 6 0.0027 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0199 0.2863 0.2863
Loa Loa (eye worm) hypothetical protein 0.0199 0.2863 0.2863
Echinococcus multilocularis short transient receptor potential channel 6 0.0027 0.0143 0.0143
Echinococcus granulosus hypothetical protein 0.0027 0.0143 0.0143
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0414 0.0414
Schistosoma mansoni transient receptor potential channel 0.0027 0.0143 0.0143
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0027 0.0143 0.0143
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0301 0.4475 0.4475
Echinococcus multilocularis transient receptor potential cation channel 0.0027 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.0143
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0651 1 1
Echinococcus multilocularis potassium large conductance calcium activated 0.0027 0.0143 0.0143
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0027 0.0143 0.0143
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0143 0.0143
Brugia malayi hypothetical protein 0.0027 0.0143 0.0143
Loa Loa (eye worm) calcium channel 0.0651 1 1
Echinococcus multilocularis transfer RNA-Gly 0.0027 0.0143 0.0143
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0143 0.0143
Echinococcus multilocularis calcium activated potassium channel 0.0027 0.0143 0.0143
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0027 0.0143 0.0143
Toxoplasma gondii hypothetical protein 0.0199 0.2863 0.8688
Echinococcus multilocularis potassium voltage gated channel protein 0.0027 0.0143 0.0143
Echinococcus multilocularis potassium voltage gated channel protein 0.0027 0.0143 0.0143
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0414 0.0414
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.0143
Echinococcus multilocularis hyperpolarization activated cyclic 0.0027 0.0143 0.0143
Echinococcus multilocularis two pore calcium channel protein 2 0.0027 0.0143 0.0143
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0027 0.0143 0.0143
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0027 0.0143 0.0435
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.0143
Echinococcus multilocularis voltage dependent calcium channel 0.0651 1 1
Echinococcus granulosus sodium leak channel non selective protein 0.0027 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.0143
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0027 0.0143 0.0143
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0027 0.0143 0.0143
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0027 0.0143 0.0143
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0143 0.0435
Loa Loa (eye worm) voltage-gated potassium channel 0.0027 0.0143 0.0143
Echinococcus multilocularis transient receptor potential cation channel 0.0027 0.0143 0.0143
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0027 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0033 0.0235 0.0235
Brugia malayi cation channel family protein 0.0027 0.0143 0.0143
Echinococcus granulosus sodium and chloride dependent glycine 0.008 0.0981 0.0981
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0143 0.0143
Echinococcus granulosus transient receptor potential cation channel 0.0027 0.0143 0.0143
Schistosoma mansoni calcium-activated potassium channel 0.0027 0.0143 0.0143
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0 0.5
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0027 0.0143 0.0143
Echinococcus multilocularis hyperpolarization activated cyclic 0.0027 0.0143 0.0143
Toxoplasma gondii hypothetical protein 0.0027 0.0143 0.0435
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0027 0.0143 0.0143
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0143 0.0143
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.0143
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0027 0.0143 0.0143
Echinococcus multilocularis voltage dependent calcium channel 0.0651 1 1
Echinococcus granulosus calcium activated potassium channel 0.0027 0.0143 0.0143
Loa Loa (eye worm) ryanodine receptor 0.0027 0.0143 0.0143
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0477 0.0477
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0651 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0027 0.0143 0.0143
Echinococcus granulosus short transient receptor potential channel 6 0.0027 0.0143 0.0143
Loa Loa (eye worm) voltage-gated potassium channel 0.0027 0.0143 0.0143
Schistosoma mansoni transient receptor potential channel 0.0027 0.0143 0.0143
Echinococcus granulosus potassium voltage gated channel protein 0.0027 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.0143
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0027 0.0143 0.0143
Echinococcus granulosus TRP transient receptor potential channel 0.0027 0.0143 0.0143
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.008 0.0981 0.0981
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0027 0.0143 0.0143
Echinococcus granulosus high voltage activated calcium channel beta 0.0146 0.2023 0.2023
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0027 0.0143 0.5
Schistosoma mansoni hypothetical protein 0.0027 0.0143 0.0143
Brugia malayi cation channel family protein 0.0027 0.0143 0.0143
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0143 0.0143
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0143 0.0143
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0027 0.0143 0.0435
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0414 0.0414
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0027 0.0143 0.0143
Echinococcus granulosus transient receptor potential cation channel 0.0027 0.0143 0.0143
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0143 0.0143
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0027 0.0143 0.0143
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0143 0.0143
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0651 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.0143
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0651 1 1
Brugia malayi ion channel NompC 0.0027 0.0143 0.0143
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0027 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.008 0.0981 0.0981
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.0143
Echinococcus granulosus transient receptor potential cation channel 0.0027 0.0143 0.0143
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0143 0.0435
Brugia malayi Sodium:neurotransmitter symporter family protein 0.008 0.0981 0.0981
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0027 0.0143 0.0143
Toxoplasma gondii transporter, cation channel family protein 0.0027 0.0143 0.0435
Echinococcus multilocularis transient receptor potential gamma protein 0.0027 0.0143 0.0143
Echinococcus multilocularis transient receptor potential cation channel 0.0027 0.0143 0.0143
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0027 0.0143 0.0143
Echinococcus multilocularis conserved hypothetical protein 0.0027 0.0143 0.0143
Echinococcus granulosus voltage gated potassium channel 0.0027 0.0143 0.0143
Echinococcus multilocularis transient receptor potential cation channel 0.0027 0.0143 0.0143
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0027 0.0143 0.0143
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0146 0.2023 0.2023
Echinococcus granulosus voltage dependent calcium channel 0.0227 0.3295 0.3295
Brugia malayi Cyclic-nucleotide gated cation channel 0.0027 0.0143 0.0143
Toxoplasma gondii transporter, cation channel family protein 0.0027 0.0143 0.0435
Echinococcus granulosus potassium voltage gated channel protein 0.0027 0.0143 0.0143
Schistosoma mansoni sodium/chloride dependent transporter 0.008 0.0981 0.0981
Schistosoma mansoni voltage-dependent calcium channel 0.0027 0.0143 0.0143
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0143 0.0143
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0414 0.0414
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0027 0.0143 0.0143
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0651 1 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0651 1 1
Schistosoma mansoni vesicular amine transporter 0.0027 0.0143 0.0143
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0414 0.0414
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.0143 0.0143
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0027 0.0143 0.0143
Echinococcus granulosus two pore calcium channel protein 2 0.0027 0.0143 0.0143
Echinococcus granulosus transient receptor potential gamma protein 0.0027 0.0143 0.0143
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0651 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0027 0.0143 0.0143
Toxoplasma gondii transporter, cation channel family protein 0.0227 0.3295 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0027 0.0143 1
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0143 0.0143
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0027 0.0143 0.0143
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0414 0.0414
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0027 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0651 1 1
Echinococcus multilocularis voltage gated potassium channel 0.0027 0.0143 0.0143
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0477 0.0477
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0027 0.0143 0.0143
Echinococcus multilocularis sodium leak channel non selective protein 0.0027 0.0143 0.0143
Echinococcus granulosus potassium voltage gated channel protein 0.0027 0.0143 0.0143
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.0143
Echinococcus multilocularis transient receptor potential cation channel 0.0027 0.0143 0.0143
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0027 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.0143
Echinococcus multilocularis voltage gated potassium channel 0.0027 0.0143 0.0143
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0027 0.0143 0.0143
Echinococcus multilocularis two pore calcium channel protein 1 0.0027 0.0143 0.0143
Echinococcus granulosus hyperpolarization activated cyclic 0.0027 0.0143 0.0143
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0235 0.0235
Echinococcus multilocularis shaker cognate 0.0027 0.0143 0.0143
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.0143
Echinococcus multilocularis short transient receptor potential channel 6 0.0027 0.0143 0.0143
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0027 0.0143 0.0143
Echinococcus multilocularis sodium and chloride dependent glycine 0.008 0.0981 0.0981
Brugia malayi olfactory channel protein osm-9 0.0027 0.0143 0.0143
Schistosoma mansoni hypothetical protein 0.0033 0.0235 0.0235
Echinococcus granulosus potassium voltage gated channel protein 0.0027 0.0143 0.0143
Echinococcus granulosus potassium large conductance calcium activated 0.0027 0.0143 0.0143
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0477 0.0477
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0027 0.0143 0.0143
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0 0.5
Echinococcus granulosus voltage gated hydrogen channel 1 0.0027 0.0143 0.0143
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0027 0.0143 0.0143
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0414 0.0414
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0027 0.0143 0.0143
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0027 0.0143 0.0143
Leishmania major hypothetical protein, conserved 0.0027 0.0143 1
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0027 0.0143 1
Schistosoma mansoni transient receptor potential channel 4 0.0027 0.0143 0.0143
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0027 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0227 0.3295 0.3295
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0651 1 1
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0027 0.0143 0.0143
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0 0.5
Loa Loa (eye worm) hypothetical protein 0.008 0.0981 0.0981
Echinococcus granulosus shaker cognate 0.0027 0.0143 0.0143
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0027 0.0143 0.0143
Echinococcus granulosus sodium channel protein 0.0027 0.0143 0.0143
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0301 0.4475 0.4475
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0143 0.0143
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0027 0.0143 0.0143
Schistosoma mansoni two-pore calcium channel 0.0027 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.0143
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0027 0.0143 0.0143
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0027 0.0143 0.0143
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0027 0.0143 0.0143
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0 0.5
Echinococcus multilocularis potassium voltage gated channel protein 0.0027 0.0143 0.0143
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0027 0.0143 0.0143
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0143 0.0143

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) > 90 % Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 20 uM after 24 hrs by MTT assay in presence of LPS ChEMBL. 25311566

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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