Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | glycogen phosphorylase | 0.0123 | 0.4637 | 0.5 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0137 | 0.5352 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1621 | 0.1621 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0123 | 0.4637 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0156 | 0.6324 | 0.9026 |
Entamoeba histolytica | glycogenphosphorylase, putative | 0.0053 | 0.1048 | 0.2261 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0033 | 0.0000000013634 | 0.5 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0053 | 0.1048 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0123 | 0.4637 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0123 | 0.4637 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0064 | 0.1621 | 0.4422 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0123 | 0.4637 | 0.6524 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0123 | 0.4639 | 0.8034 |
Brugia malayi | carbohydrate phosphorylase | 0.0123 | 0.4637 | 0.6524 |
Giardia lamblia | Glycogen phosphorylase | 0.0123 | 0.4637 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0168 | 0.6981 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0238 | 0.0917 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0123 | 0.4637 | 0.6524 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0238 | 0.0513 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0748 | 0.0756 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0748 | 0.1295 |
Echinococcus granulosus | bloom syndrome protein | 0.0156 | 0.6324 | 0.9026 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0053 | 0.1048 | 0.5 |
Schistosoma mansoni | DNA helicase recq1 | 0.0064 | 0.1621 | 0.2807 |
Schistosoma mansoni | glycogen phosphorylase | 0.0123 | 0.4637 | 0.803 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0748 | 0.0756 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0123 | 0.4637 | 0.4637 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0156 | 0.6324 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0064 | 0.1621 | 0.1621 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0238 | 0.0513 |
Entamoeba histolytica | recQ family helicase, putative | 0.0083 | 0.2594 | 0.5594 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0748 | 0.1295 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0064 | 0.1621 | 0.2051 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0064 | 0.1621 | 0.2051 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0168 | 0.6981 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0238 | 0.0917 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0748 | 0.0748 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0083 | 0.2594 | 1 |
Schistosoma mansoni | alpha glucosidase | 0.0037 | 0.0238 | 0.0412 |
Loa Loa (eye worm) | RecQ helicase | 0.0156 | 0.6324 | 0.6324 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0064 | 0.1621 | 0.2051 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0748 | 0.0756 |
Schistosoma mansoni | glycogen phosphorylase | 0.0123 | 0.4637 | 0.803 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0064 | 0.1621 | 0.2051 |
Schistosoma mansoni | glycogen phosphorylase | 0.0053 | 0.1048 | 0.1815 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0748 | 0.0756 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0123 | 0.4637 | 0.6524 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0105 | 0.3731 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0123 | 0.4637 | 0.6524 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0064 | 0.1621 | 0.4422 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0104 | 0.3666 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0168 | 0.6981 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0037 | 0.0238 | 0.0238 |
Echinococcus multilocularis | bloom syndrome protein | 0.0156 | 0.6324 | 0.9026 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0748 | 0.1295 |
Echinococcus granulosus | glycogen phosphorylase | 0.0123 | 0.4637 | 0.6524 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0064 | 0.1621 | 0.2051 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0123 | 0.4637 | 0.7228 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0168 | 0.6981 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0238 | 0.0649 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0083 | 0.2594 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.0064 | 0.1621 | 0.2807 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0123 | 0.4637 | 0.7228 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0053 | 0.1048 | 0.2261 |
Schistosoma mansoni | alpha-glucosidase | 0.0145 | 0.5774 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0064 | 0.1621 | 0.2051 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0156 | 0.6324 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0083 | 0.2594 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0083 | 0.2594 | 0.3871 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0053 | 0.1048 | 0.2261 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0748 | 0.0756 |
Echinococcus granulosus | glycogen phosphorylase | 0.0123 | 0.4637 | 0.6524 |
Schistosoma mansoni | alpha-glucosidase | 0.0145 | 0.5774 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0168 | 0.6981 | 0.6981 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Displacement of [3H]E1 from human placental cytosolic17beta-HSD1 at 1 uM after 10 mins by cell-free assay | ChEMBL. | 25259513 | |
Inhibition (binding) | = 16 % | Displacement of [3H]E2 from human placental microsomal 17beta-HSD2 at 1 uM after 20 mins by cell-free assay | ChEMBL. | 25259513 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.