Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | fused N-acetyl glucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyl transferase | Starlite/ChEMBL | References |
Homo sapiens | aurora kinase B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | aurora kinase B | 303 aa | 299 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Bile acid receptor homolog | 0.1679 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0177 | 0.0334 | 1 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.0684 | 0.3597 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0177 | 0.0334 | 0.0302 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0334 | 0.0302 |
Treponema pallidum | licC protein (licC) | 0.0125 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0177 | 0.0334 | 0.0302 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0177 | 0.0334 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0177 | 0.0334 | 0.0302 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0177 | 0.0334 | 0.0302 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0177 | 0.0334 | 1 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.0684 | 0.3597 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0177 | 0.0334 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0177 | 0.0334 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0177 | 0.0334 | 0.0302 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0177 | 0.0334 | 0.0302 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0177 | 0.0334 | 0.0302 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0177 | 0.0334 | 0.0302 |
Echinococcus granulosus | FTZ F1 alpha | 0.0177 | 0.0334 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0334 | 0.0302 |
Loa Loa (eye worm) | hypothetical protein | 0.1679 | 1 | 1 |
Mycobacterium leprae | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.0684 | 0.3597 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0177 | 0.0334 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0177 | 0.0334 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0177 | 0.0334 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0177 | 0.0334 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0177 | 0.0334 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0177 | 0.0334 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0177 | 0.0334 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0177 | 0.0334 | 0.0302 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0177 | 0.0334 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0177 | 0.0334 | 0.0302 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0177 | 0.0334 | 0.0302 |
Brugia malayi | steroid hormone receptor | 0.0177 | 0.0334 | 0.0302 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0177 | 0.0334 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0177 | 0.0334 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0177 | 0.0334 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0177 | 0.0334 | 0.0302 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0334 | 0.0302 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0177 | 0.0334 | 0.0302 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0177 | 0.0334 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0177 | 0.0334 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0177 | 0.0334 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0177 | 0.0334 | 0.0302 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0177 | 0.0334 | 0.0302 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0177 | 0.0334 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0177 | 0.0334 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0177 | 0.0334 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0177 | 0.0334 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0177 | 0.0334 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0177 | 0.0334 | 0.0302 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0177 | 0.0334 | 0.0302 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0177 | 0.0334 | 0.0302 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0177 | 0.0334 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0334 | 0.0302 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0177 | 0.0334 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0177 | 0.0334 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0177 | 0.0334 | 0.0302 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0684 | 0.3597 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0177 | 0.0334 | 0.0302 |
Brugia malayi | nuclear hormone receptor | 0.0177 | 0.0334 | 0.0302 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0177 | 0.0334 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0177 | 0.0334 | 0.0302 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0334 | 0.0302 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0177 | 0.0334 | 0.0302 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0177 | 0.0334 | 0.0302 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0334 | 0.0302 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0125 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0177 | 0.0334 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0177 | 0.0334 | 0.0302 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0334 | 0.0302 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0177 | 0.0334 | 0.0302 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0177 | 0.0334 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.91 uM | Inhibition of human AURKB incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assay | ChEMBL. | 25262942 |
IC50 (binding) | = 8.2 uM | Inhibition of Escherichia coli ATCC 27325 GlmU expressed in Escherichia coli HMS174(DE3) incubated for 15 mins prior to MgCl2 addition measured after 30 mins by malachite green staining-based assay | ChEMBL. | 25262942 |
IC50 (binding) | > 30 uM | Inhibition of human IRAK4 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assay | ChEMBL. | 25262942 |
IC50 (binding) | > 30 uM | Inhibition of human IRAK1 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assay | ChEMBL. | 25262942 |
IC50 (binding) | > 30 uM | Inhibition of human JAK1 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assay | ChEMBL. | 25262942 |
IC50 (binding) | > 30 uM | Inhibition of human JAK2 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assay | ChEMBL. | 25262942 |
IC50 (binding) | > 30 uM | Inhibition of human JAK3 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assay | ChEMBL. | 25262942 |
IC50 (binding) | > 30 uM | Inhibition of human CDK1 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assay | ChEMBL. | 25262942 |
IC50 (binding) | > 30 uM | Inhibition of human CDK2 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assay | ChEMBL. | 25262942 |
IC50 (binding) | > 30 uM | Inhibition of human CDK9 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assay | ChEMBL. | 25262942 |
PB (ADMET) | = 98.4 % | Serum protein binding in human at 10 uM after 30 mins by ultrafiltration method | ChEMBL. | 25262942 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.