Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase XII | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | carbonic anhydrase XII | 354 aa | 295 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0353 | 0.6858 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0353 | 0.6858 | 0.6858 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.029 | 0.4672 | 0.6812 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0296 | 0.4899 | 0.7143 |
Trichomonas vaginalis | AGC family protein kinase | 0.0444 | 1 | 1 |
Echinococcus granulosus | 3-phosphoinositide-dependent protein kinase 1 | 0.0353 | 0.6858 | 1 |
Echinococcus granulosus | nervana 2 | 0.029 | 0.4672 | 0.6812 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0296 | 0.4899 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0444 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0353 | 0.6858 | 0.6858 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0444 | 1 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0248 | 0.3222 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0444 | 1 | 1 |
Echinococcus multilocularis | nervana 2 | 0.029 | 0.4672 | 0.6812 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0248 | 0.3222 | 0.3222 |
Echinococcus multilocularis | 3 phosphoinositide dependent protein kinase 1 | 0.0353 | 0.6858 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0296 | 0.4899 | 0.4899 |
Trichomonas vaginalis | AGC family protein kinase | 0.0444 | 1 | 1 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0296 | 0.4899 | 0.5 |
Trypanosoma cruzi | Protein kinase B | 0.0296 | 0.4899 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.029 | 0.4672 | 0.6812 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0296 | 0.4899 | 0.4899 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0296 | 0.4899 | 1 |
Echinococcus granulosus | nervana 2 | 0.029 | 0.4672 | 0.6812 |
Entamoeba histolytica | protein kinase, putative | 0.0353 | 0.6858 | 0.6858 |
Brugia malayi | phosphoinositide-dependent protein kinase I | 0.0353 | 0.6858 | 0.6858 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0248 | 0.3222 | 0.3222 |
Trichomonas vaginalis | AGC family protein kinase | 0.0444 | 1 | 1 |
Giardia lamblia | Kinase, AGC PKA | 0.0296 | 0.4899 | 0.5 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0353 | 0.6858 | 0.6858 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0248 | 0.3222 | 0.3222 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0444 | 1 | 1 |
Entamoeba histolytica | protein kinase 2, putative | 0.0296 | 0.4899 | 0.4899 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0248 | 0.3222 | 0.4698 |
Trichomonas vaginalis | AGC family protein kinase | 0.0444 | 1 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0296 | 0.4899 | 0.7143 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0296 | 0.4899 | 0.7143 |
Trichomonas vaginalis | AGC family protein kinase | 0.0353 | 0.6858 | 0.6858 |
Trichomonas vaginalis | AGC family protein kinase | 0.0444 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0248 | 0.3222 | 0.4698 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0353 | 0.6858 | 0.6858 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0444 | 1 | 1 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.029 | 0.4672 | 0.6812 |
Entamoeba histolytica | protein kinase, putative | 0.0444 | 1 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0296 | 0.4899 | 0.7143 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0296 | 0.4899 | 0.7143 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0296 | 0.4899 | 0.5 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.029 | 0.4672 | 0.6812 |
Trichomonas vaginalis | AGC family protein kinase | 0.0444 | 1 | 1 |
Echinococcus multilocularis | nervana 2 | 0.029 | 0.4672 | 0.6812 |
Entamoeba histolytica | protein kinase, putative | 0.0444 | 1 | 1 |
Toxoplasma gondii | AGC kinase | 0.0444 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.3222 | 0.4698 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0296 | 0.4899 | 0.7143 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0248 | 0.3222 | 0.3222 |
Trichomonas vaginalis | AGC family protein kinase | 0.0353 | 0.6858 | 0.6858 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0296 | 0.4899 | 0.7143 |
Brugia malayi | Protein kinase domain containing protein | 0.0444 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.3222 | 0.4698 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 28 nM | Inhibition of human CA-9 after 15 mins by stopped-flow CO2 hydration method | ChEMBL. | 25267005 |
Ki (binding) | = 58 nM | Inhibition of human CA-12 after 15 mins by stopped-flow CO2 hydration method | ChEMBL. | 25267005 |
Ki (binding) | = 499 nM | Inhibition of human CA-1 after 15 mins by stopped-flow CO2 hydration method | ChEMBL. | 25267005 |
Ki (binding) | = 710 nM | Inhibition of human CA-2 after 15 mins by stopped-flow CO2 hydration method | ChEMBL. | 25267005 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.