Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | myeloperoxidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | myeloperoxidase | 745 aa | 717 aa | 37.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0336 | 0.0517 | 0.3296 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.0499 | 0.04 |
Loa Loa (eye worm) | hypothetical protein | 0.0503 | 0.1025 | 0.0932 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0441 | 0.0837 | 1 |
Brugia malayi | Peptidase family M13 containing protein | 0.0665 | 0.1516 | 0.1428 |
Loa Loa (eye worm) | hypothetical protein | 0.0492 | 0.099 | 0.0896 |
Plasmodium vivax | hypothetical protein, conserved | 0.0165 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0503 | 0.1025 | 0.0932 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0242 | 0.0234 | 0.0133 |
Loa Loa (eye worm) | hypothetical protein | 0.0503 | 0.1025 | 0.0932 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0217 | 0.0115 |
Loa Loa (eye worm) | hypothetical protein | 0.0665 | 0.1516 | 0.1428 |
Loa Loa (eye worm) | hypothetical protein | 0.0665 | 0.1516 | 0.1428 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0492 | 0.099 | 0.0896 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0665 | 0.1516 | 0.5377 |
Schistosoma mansoni | hypothetical protein | 0.0282 | 0.0355 | 0.2207 |
Loa Loa (eye worm) | matrixin family protein | 0.0441 | 0.0837 | 0.0742 |
Brugia malayi | Hemopexin family protein | 0.0282 | 0.0355 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.0492 | 0.099 | 0.0896 |
Loa Loa (eye worm) | hypothetical protein | 0.0503 | 0.1025 | 0.0932 |
Plasmodium vivax | transporter, putative | 0.0165 | 0 | 0.5 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0665 | 0.1516 | 0.8805 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.0234 | 0.0133 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0665 | 0.1516 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0336 | 0.0517 | 0.3296 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0724 | 0.1692 | 1 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0336 | 0.0517 | 0.3296 |
Loa Loa (eye worm) | hypothetical protein | 0.0492 | 0.099 | 0.0896 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0724 | 0.1692 | 1 |
Onchocerca volvulus | 0.033 | 0.0499 | 0.539 | |
Mycobacterium tuberculosis | Possible exported protein | 0.1029 | 0.2618 | 1 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0665 | 0.1516 | 0.1428 |
Loa Loa (eye worm) | hypothetical protein | 0.0492 | 0.099 | 0.0896 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0665 | 0.1516 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0503 | 0.1025 | 0.0932 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0336 | 0.0517 | 0.3296 |
Loa Loa (eye worm) | hypothetical protein | 0.0503 | 0.1025 | 0.0932 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.3465 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0481 | 0.0958 | 0.0864 |
Plasmodium vivax | serine-repeat antigen 4 (SERA) | 0.0165 | 0 | 0.5 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0665 | 0.1516 | 0.8805 |
Onchocerca volvulus | 0.0282 | 0.0355 | 0.3431 | |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0237 | 0.0217 | 0.1283 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0237 | 0.0217 | 0.0115 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0199 | 0.0103 | 0.0516 |
Loa Loa (eye worm) | hypothetical protein | 0.0665 | 0.1516 | 0.1428 |
Loa Loa (eye worm) | matrixin family protein | 0.0481 | 0.0958 | 0.0864 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0492 | 0.099 | 0.0896 |
Toxoplasma gondii | peptidase family M13 protein | 0.0665 | 0.1516 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0441 | 0.0837 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0665 | 0.1516 | 1 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0336 | 0.0517 | 0.3296 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 807 nM | Inhibition of myeloperoxidase (unknown origin) assessed as reduction in enzymatic hypochlorous acid production by spectrophotometry based taurine chlorination assay | ChEMBL. | 25438766 |
Inhibition (binding) | Inhibition of myeloperoxidase (unknown origin) assessed as reduction in H2O2 consumption by H2O2-specific electrode based assay | ChEMBL. | 25438766 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.