Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | MET proto-oncogene, receptor tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | para nitrobenzyl esterase | 0.0251 | 0.1621 | 0.1549 |
Brugia malayi | plexin A | 0.0025 | 0.0085 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.1621 | 0.1621 |
Onchocerca volvulus | 0.0251 | 0.1621 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.1485 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.1621 | 0.1621 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.1621 | 0.1621 |
Brugia malayi | Carboxylesterase family protein | 0.0251 | 0.1621 | 0.1571 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1485 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0251 | 0.1621 | 0.1549 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0251 | 0.1621 | 0.1621 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0251 | 0.1621 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1485 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0251 | 0.1621 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.1621 | 0.1621 |
Onchocerca volvulus | 0.0251 | 0.1621 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0059 | 0.0059 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0251 | 0.1621 | 0.1621 |
Brugia malayi | Carboxylesterase family protein | 0.1485 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0251 | 0.1621 | 0.1621 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0251 | 0.1621 | 0.1549 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1485 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0251 | 0.1621 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.1621 | 0.1621 |
Brugia malayi | hypothetical protein | 0.0251 | 0.1621 | 0.1571 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1485 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0251 | 0.1621 | 0.1571 |
Echinococcus multilocularis | acetylcholinesterase | 0.1485 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0251 | 0.1621 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0251 | 0.1621 | 0.1621 |
Echinococcus granulosus | acetylcholinesterase | 0.1485 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.1621 | 0.1621 |
Echinococcus multilocularis | neuroligin | 0.0251 | 0.1621 | 0.1549 |
Brugia malayi | Carboxylesterase family protein | 0.0251 | 0.1621 | 0.1571 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0251 | 0.1621 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0251 | 0.1621 | 0.1549 |
Schistosoma mansoni | acetylcholinesterase | 0.0251 | 0.1621 | 0.1621 |
Schistosoma mansoni | plexin | 0.0021 | 0.0059 | 0.0059 |
Onchocerca volvulus | 0.0251 | 0.1621 | 1 | |
Echinococcus granulosus | BC026374 protein S09 family | 0.0251 | 0.1621 | 0.1549 |
Loa Loa (eye worm) | plexin A | 0.0025 | 0.0085 | 0.0085 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0251 | 0.1621 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0251 | 0.1621 | 0.1621 |
Echinococcus granulosus | carboxylesterase 5A | 0.1485 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0251 | 0.1621 | 0.1549 |
Loa Loa (eye worm) | hypothetical protein | 0.1485 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1485 | 1 | 1 |
Onchocerca volvulus | 0.0251 | 0.1621 | 1 | |
Echinococcus granulosus | neuroligin | 0.0251 | 0.1621 | 0.1549 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0251 | 0.1621 | 0.1621 |
Onchocerca volvulus | 0.0251 | 0.1621 | 1 | |
Schistosoma mansoni | gliotactin | 0.0251 | 0.1621 | 0.1621 |
Brugia malayi | Carboxylesterase family protein | 0.0251 | 0.1621 | 0.1571 |
Echinococcus multilocularis | acetylcholinesterase | 0.1485 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.1621 | 0.1621 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0251 | 0.1621 | 0.1621 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 15.49 nM | Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assay | ChEMBL. | 25438768 |
IC50 (functional) | = 0.56 uM | Cytotoxicity against human A549 cells after 72 hrs by MTT assay | ChEMBL. | 25438768 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 25438768 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.