Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1465 | 0.2495 | 0.2495 |
Loa Loa (eye worm) | hypothetical protein | 0.1082 | 0.153 | 0.153 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0678 | 0.0508 | 0.1141 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.1465 | 0.2495 | 0.2093 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0678 | 0.0508 | 0.1141 |
Loa Loa (eye worm) | hypothetical protein | 0.1465 | 0.2495 | 0.2495 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0678 | 0.0508 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.1082 | 0.153 | 0.153 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0678 | 0.0508 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0739 | 0.0663 | 0.2658 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.1465 | 0.2495 | 0.5601 |
Entamoeba histolytica | aminopeptidase, putative | 0.0678 | 0.0508 | 0.5 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0739 | 0.0663 | 0.2658 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0678 | 0.0508 | 0.2037 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0678 | 0.0508 | 0.1141 |
Mycobacterium leprae | probable zinc metalloprotease | 0.1465 | 0.2495 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0678 | 0.0508 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1082 | 0.153 | 0.153 |
Loa Loa (eye worm) | hypothetical protein | 0.1108 | 0.1594 | 0.1594 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.1818 | 0.3386 | 0.3386 |
Brugia malayi | Peptidase family M13 containing protein | 0.1465 | 0.2495 | 0.2093 |
Loa Loa (eye worm) | hypothetical protein | 0.1108 | 0.1594 | 0.1594 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0678 | 0.0508 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0678 | 0.0508 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.1465 | 0.2495 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1465 | 0.2495 | 0.2495 |
Mycobacterium ulcerans | zinc metalloprotease | 0.1465 | 0.2495 | 1 |
Toxoplasma gondii | peptidase family M13 protein | 0.1465 | 0.2495 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0678 | 0.0508 | 0.5 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0678 | 0.0508 | 0.1141 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0678 | 0.0508 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.1082 | 0.153 | 0.153 |
Loa Loa (eye worm) | hypothetical protein | 0.1563 | 0.2743 | 0.2743 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0678 | 0.0508 | 0.1141 |
Echinococcus multilocularis | aminopeptidase N | 0.2241 | 0.4454 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1986 | 0.381 | 0.381 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0678 | 0.0508 | 0.5 |
Onchocerca volvulus | 0.2241 | 0.4454 | 1 | |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0678 | 0.0508 | 0.1141 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0678 | 0.0508 | 0.2037 |
Loa Loa (eye worm) | hypothetical protein | 0.1082 | 0.153 | 0.153 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 0.0629 | 0.0629 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.4438 | 1 | 1 |
Echinococcus granulosus | aminopeptidase N | 0.2241 | 0.4454 | 1 |
Onchocerca volvulus | 0.0726 | 0.0629 | 0.0307 | |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0739 | 0.0663 | 0.2658 |
Loa Loa (eye worm) | hypothetical protein | 0.1108 | 0.1594 | 0.1594 |
Loa Loa (eye worm) | aminopeptidase N | 0.0678 | 0.0508 | 0.0508 |
Loa Loa (eye worm) | hypothetical protein | 0.1108 | 0.1594 | 0.1594 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0678 | 0.0508 | 0.1141 |
Loa Loa (eye worm) | hypothetical protein | 0.1108 | 0.1594 | 0.1594 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0678 | 0.0508 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1082 | 0.153 | 0.153 |
Brugia malayi | Peptidase family M1 containing protein | 0.2241 | 0.4454 | 0.4157 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0739 | 0.0663 | 0.2658 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0678 | 0.0508 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0678 | 0.0508 | 0.1141 |
Loa Loa (eye worm) | hypothetical protein | 0.1108 | 0.1594 | 0.1594 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.1465 | 0.2495 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0678 | 0.0508 | 0.1141 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.1465 | 0.2495 | 0.5601 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0678 | 0.0508 | 0.1141 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0739 | 0.0663 | 0.2658 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 0.02 ug ml-1 | The compound was tested for anticancer activity against P815 (sensitive) cell lines of mouse leukemia | ChEMBL. | 7420353 |
ID50 (functional) | = 0.06 ug ml-1 | The compound was tested for anticancer activity against L5178Y (sensitive) cell lines of mouse leukemia | ChEMBL. | 7420353 |
ID50 (functional) | = 3.9 ug ml-1 | The compound was tested for anticancer activity against P815(arc-C resistant) cell lines of mouse leukemia | ChEMBL. | 7420353 |
ID50 (functional) | = 8 ug ml-1 | The compound was tested for anticancer activity against L5178Y (arc-C resistant) cell lines of mouse leukemia | ChEMBL. | 7420353 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.