Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 2c (5-HT2c) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 2 (5-HT2) receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Serotonin receptor | Get druggable targets OG5_135430 | All targets in OG5_135430 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Serotonin 2c (5-HT2c) receptor | 460 aa | 405 aa | 31.1 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Serotonin 2c (5-HT2c) receptor | 460 aa | 427 aa | 28.3 % |
Echinococcus multilocularis | g protein coupled receptor | Serotonin 2c (5-HT2c) receptor | 460 aa | 409 aa | 21.5 % |
Echinococcus granulosus | g protein coupled receptor | Serotonin 2c (5-HT2c) receptor | 460 aa | 412 aa | 19.7 % |
Echinococcus multilocularis | g protein coupled receptor | Serotonin 2c (5-HT2c) receptor | 460 aa | 412 aa | 19.9 % |
Loa Loa (eye worm) | hypothetical protein | Serotonin 2c (5-HT2c) receptor | 460 aa | 417 aa | 21.3 % |
Echinococcus multilocularis | neuropeptides capa receptor | Serotonin 2c (5-HT2c) receptor | 460 aa | 408 aa | 20.8 % |
Echinococcus granulosus | g protein coupled receptor | Serotonin 2c (5-HT2c) receptor | 460 aa | 409 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Glycogen phosphorylase | 0.066 | 1 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.066 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.066 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.066 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.066 | 1 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.066 | 1 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.066 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.066 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.066 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.066 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.066 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.066 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.066 | 1 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.066 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.066 | 1 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.066 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 12 nM | Binding affinity against 5-hydroxytryptamine 2 receptor in rat using [3H]-ketanserin as radioligand | ChEMBL. | 1479590 |
Ki (binding) | = 200 nM | Binding affinity against 5-hydroxytryptamine 1C receptor in rat using [3H]-mesulergine as radioligand | ChEMBL. | 1479590 |
Ratio (binding) | = 17 | Selectivity ratio for 5-HT1C compared to 5-HT2 receptors. | ChEMBL. | 1479590 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.