TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 451.503 | Formula: C24H31F2NO5
H donors: 4 H acceptors: 4 LogP: 2.48 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H]1N(C[C@@H]([C@H]([C@@H]1O)O)O)CC(CCCOCc1ccc(cc1)c1ccccc1)(F)F
InChi: 1S/C24H31F2NO5/c25-24(26,16-27-13-21(29)23(31)22(30)20(27)14-28)11-4-12-32-15-17-7-9-19(10-8-17)18-5-2-1-3-6-18/h1-3,5-10,20-23,28-31H,4,11-16H2/t20-,21+,22-,23-/m1/s1
InChiKey: BMDCVDRGQXCITF-KAOXLYBCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucosidase, beta, acid	Starlite/ChEMBL	References
Homo sapiens	UDP-glucose ceramide glucosyltransferase	Starlite/ChEMBL	References
Homo sapiens	glucosidase, beta (bile acid) 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Schistosoma japonicum	Non-lysosomal glucosylceramidase, putative	Get druggable targets OG5_130651	All targets in OG5_130651
Schistosoma mansoni	ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	Get druggable targets OG5_129423	All targets in OG5_129423
Echinococcus granulosus	non lysosomal glucosylceramidase	Get druggable targets OG5_130651	All targets in OG5_130651
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Schistosoma mansoni	ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848
Schistosoma mansoni	bile acid beta-glucosidase-related	Get druggable targets OG5_130651	All targets in OG5_130651
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Candida albicans	ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848
Schistosoma mansoni	bile acid beta-glucosidase-related	Get druggable targets OG5_130651	All targets in OG5_130651
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Brugia malayi	O-Glycosyl hydrolase family 30 protein	Get druggable targets OG5_129423	All targets in OG5_129423
Echinococcus granulosus	ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848
Candida albicans	ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848
Echinococcus multilocularis	non lysosomal glucosylceramidase	Get druggable targets OG5_130651	All targets in OG5_130651
Brugia malayi	Ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Schistosoma japonicum	ko:K00720 ceramide glucosyltransferase [EC2.4.1.80], putative	Get druggable targets OG5_129848	All targets in OG5_129848
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130651	All targets in OG5_130651
Onchocerca volvulus	Ceramide glucosyltransferase homolog	Get druggable targets OG5_129848	All targets in OG5_129848
Echinococcus multilocularis	bile acid beta glucosidase	Get druggable targets OG5_130651	All targets in OG5_130651
Onchocerca volvulus	Glucosylceramidase homolog	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Echinococcus granulosus	bile acid beta glucosidase	Get druggable targets OG5_130651	All targets in OG5_130651
Schistosoma japonicum	Non-lysosomal glucosylceramidase, putative	Get druggable targets OG5_130651	All targets in OG5_130651
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Loa Loa (eye worm)	ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Schistosoma japonicum	Non-lysosomal glucosylceramidase, putative	Get druggable targets OG5_130651	All targets in OG5_130651
Schistosoma japonicum	Ceramide glucosyltransferase, putative	Get druggable targets OG5_129848	All targets in OG5_129848
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Echinococcus multilocularis	ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	biogenic amine receptor	0.0049	0.0221	0.0136
Onchocerca volvulus	Ceramide glucosyltransferase homolog	0.0288	0.4463	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0049	0.0221	0.0136
Schistosoma mansoni	opsin-like receptor	0.0049	0.0221	0.0136
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0312	0.4885	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0049	0.0221	0.0176
Echinococcus multilocularis	fmrfamide receptor	0.0049	0.0221	0.0176
Brugia malayi	hypothetical protein	0.0049	0.0221	0.0361
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0049	0.0221	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.4885	1
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0312	0.4885	1
Schistosoma mansoni	amine GPCR	0.0049	0.0221	0.0136
Schistosoma mansoni	membrane associated proteins in eicosanoid and glutathione metabolism family member	0.0501	0.824	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.4885	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0216	0.3177	0.6503
Giardia lamblia	Ceramide glucosyltransferase	0.0131	0.1667	0.5
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.2982	0.6103
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0049	0.0221	0.0136
Echinococcus granulosus	g protein coupled receptor	0.0049	0.0221	0.0176
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0221	0.0176
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.4885	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0221	0.0176
Toxoplasma gondii	MAPEG family protein	0.0115	0.1386	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0049	0.0221	0.0136
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0221	0.0176
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.2982	0.6103
Echinococcus granulosus	neuropeptide s receptor	0.0049	0.0221	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0221	0.0136
Echinococcus multilocularis	g protein coupled receptor	0.0049	0.0221	0.0176
Brugia malayi	Serotonin receptor	0.0049	0.0221	0.0361
Echinococcus granulosus	serotonin receptor	0.0049	0.0221	0.0176
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0049	0.0221	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0049	0.0221	0.0136
Echinococcus granulosus	g-protein coupled receptor	0.0049	0.0221	0.0176
Brugia malayi	hypothetical protein	0.0049	0.0221	0.0361
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0049	0.0221	0.0136
Brugia malayi	hypothetical protein	0.0049	0.0221	0.0361
Echinococcus granulosus	g protein coupled receptor	0.0049	0.0221	0.0176
Schistosoma mansoni	amine GPCR	0.0049	0.0221	0.0136
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0049	0.0221	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Loa Loa (eye worm)	TYRA-2 protein	0.0049	0.0221	0.0361
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0221	0.0176
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0049	0.0221	0.0136
Echinococcus granulosus	neuropeptide receptor	0.0049	0.0221	0.0176
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.4885	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Echinococcus granulosus	tm gpcr rhodopsin	0.0049	0.0221	0.0176
Echinococcus multilocularis	bile acid beta glucosidase	0.0251	0.3811	0.3783
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Schistosoma mansoni	microsomal glutathione s-transferase	0.0115	0.1386	0.157
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0049	0.0221	0.0361
Echinococcus granulosus	G protein coupled receptor 139	0.0049	0.0221	0.0176
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0221	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Schistosoma mansoni	amine GPCR	0.0049	0.0221	0.0136
Schistosoma mansoni	opsin-like receptor	0.0049	0.0221	0.0136
Echinococcus granulosus	tm gpcr rhodopsin	0.0049	0.0221	0.0176
Echinococcus multilocularis	non lysosomal glucosylceramidase	0.0251	0.3811	0.3783
Echinococcus multilocularis	neuropeptides capa receptor	0.0049	0.0221	0.0176
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0049	0.0221	0.0361
Echinococcus multilocularis	neuropeptide receptor A26	0.0049	0.0221	0.0176
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.2982	0.6103
Brugia malayi	hypothetical protein	0.0049	0.0221	0.0361
Echinococcus granulosus	allatostatin A receptor	0.0049	0.0221	0.0176
Echinococcus granulosus	neuropeptide receptor	0.0049	0.0221	0.0176
Loa Loa (eye worm)	hypothetical protein	0.017	0.2361	0.4784
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0049	0.0221	0.0176
Schistosoma mansoni	hypothetical protein	0.0049	0.0221	0.0136
Echinococcus granulosus	biogenic amine 5HT receptor	0.0049	0.0221	0.0176
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0049	0.0221	0.0361
Schistosoma mansoni	ceramide glucosyltransferase	0.0288	0.4463	0.5354
Echinococcus multilocularis	serotonin receptor	0.0049	0.0221	0.0176
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0221	0.0136
Brugia malayi	hypothetical protein	0.0049	0.0221	0.0361
Echinococcus multilocularis	fmrfamide receptor	0.0049	0.0221	0.0176
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0221	0.0136
Echinococcus multilocularis	neuropeptide Y receptor	0.0049	0.0221	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Echinococcus multilocularis	microsomal glutathione S transferase 3	0.0115	0.1386	0.1347
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0049	0.0221	0.0176
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0049	0.0221	0.0176
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0221	0.0136
Echinococcus multilocularis	neuropeptide receptor	0.0049	0.0221	0.0176
Echinococcus multilocularis	sex peptide receptor	0.0049	0.0221	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Echinococcus granulosus	sex peptide receptor	0.0049	0.0221	0.0176
Echinococcus granulosus	somatostatin receptor	0.0049	0.0221	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Loa Loa (eye worm)	neuropeptide F receptor	0.0049	0.0221	0.0361
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0049	0.0221	0.0176
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0049	0.0221	0.0176
Echinococcus multilocularis	g-protein coupled receptor	0.0049	0.0221	0.0176
Onchocerca volvulus	Glucosylceramidase homolog	0.0205	0.2982	0.6508
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0049	0.0221	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Brugia malayi	putative neuropeptide receptor	0.0049	0.0221	0.0361
Echinococcus granulosus	g protein coupled receptor	0.0049	0.0221	0.0176
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0221	0.0176
Echinococcus granulosus	neuropeptide Y receptor	0.0049	0.0221	0.0176
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.4885	1
Echinococcus multilocularis	ceramide glucosyltransferase	0.0288	0.4463	0.4437
Brugia malayi	neuropeptide F receptor	0.0049	0.0221	0.0361
Echinococcus multilocularis	g protein coupled receptor	0.0049	0.0221	0.0176
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0221	0.0176
Echinococcus multilocularis	neuropeptide s receptor	0.0049	0.0221	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.2982	0.6103
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0221	0.0176
Echinococcus granulosus	biogenic amine 5HT receptor	0.0049	0.0221	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Schistosoma mansoni	neuropeptide F-like receptor	0.0049	0.0221	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0221	0.0176
Brugia malayi	GnHR receptor homolog	0.0049	0.0221	0.0361
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0049	0.0221	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0221	0.0176
Echinococcus granulosus	7TM GPCR rhodopsin	0.0049	0.0221	0.0176
Brugia malayi	neuropeptide F receptor	0.0049	0.0221	0.0361
Brugia malayi	sulfakinin receptor protein	0.0049	0.0221	0.0361
Schistosoma mansoni	neuropeptide receptor	0.0049	0.0221	0.0136
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0049	0.0221	0.0136
Echinococcus multilocularis	g protein coupled receptor	0.0049	0.0221	0.0176
Brugia malayi	Melatonin receptor type 1A	0.0049	0.0221	0.0361
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0049	0.0221	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Schistosoma mansoni	biogenic amine receptor	0.0049	0.0221	0.0136
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0049	0.0221	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0221	0.0136
Loa Loa (eye worm)	G-protein coupled receptor	0.0049	0.0221	0.0361
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0049	0.0221	0.0176
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0049	0.0221	0.0136
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0049	0.0221	0.0136
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0221	0.0176
Schistosoma mansoni	myosin xvIII	0.0049	0.0221	0.0136
Echinococcus multilocularis	G protein coupled receptor 139	0.0049	0.0221	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Echinococcus multilocularis	orexin receptor type 2	0.0049	0.0221	0.0176
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0049	0.0221	0.0361
Brugia malayi	G-protein coupled receptor	0.0049	0.0221	0.0361
Echinococcus granulosus	non lysosomal glucosylceramidase	0.0251	0.3811	0.3783
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.4885	1
Echinococcus granulosus	neuropeptides capa receptor	0.0049	0.0221	0.0176
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0049	0.0221	0.0176
Brugia malayi	larval opioid receptor	0.0049	0.0221	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0049	0.0221	0.0176
Schistosoma mansoni	opsin-like receptor	0.0049	0.0221	0.0136
Schistosoma mansoni	bile acid beta-glucosidase-related	0.0251	0.3811	0.4552
Brugia malayi	hypothetical protein	0.0049	0.0221	0.0361
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0049	0.0221	0.0361
Echinococcus granulosus	orexin receptor type 2	0.0049	0.0221	0.0176
Echinococcus multilocularis	neuropeptides capa receptor	0.0049	0.0221	0.0176
Brugia malayi	G-protein coupled receptor	0.0049	0.0221	0.0361
Trichomonas vaginalis	glucosylceramidase, putative	0.0216	0.3177	0.6503
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0049	0.0221	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Schistosoma mansoni	neuropeptide receptor	0.0049	0.0221	0.0136
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0049	0.0221	0.0136
Echinococcus granulosus	dro:myosuppressin receptor	0.0049	0.0221	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Brugia malayi	RE15519p	0.0049	0.0221	0.0361
Schistosoma mansoni	amine GPCR	0.0049	0.0221	0.0136
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0049	0.0221	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Schistosoma mansoni	bile acid beta-glucosidase-related	0.0251	0.3811	0.4552
Echinococcus granulosus	fmrfamide receptor	0.0049	0.0221	0.0176
Schistosoma mansoni	hypothetical protein	0.0049	0.0221	0.0136
Brugia malayi	Serotonin receptor	0.0049	0.0221	0.0361
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.06	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0049	0.0221	0.0136
Echinococcus granulosus	bile acid beta glucosidase	0.0251	0.3811	0.3783
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0049	0.0221	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Brugia malayi	G protein-coupled receptor	0.0049	0.0221	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0049	0.0221	0.0176
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0049	0.0221	0.0361
Echinococcus granulosus	neuropeptide receptor A26	0.0049	0.0221	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Brugia malayi	Dopamine receptor protein 2	0.0049	0.0221	0.0361
Echinococcus granulosus	neuropeptide Y receptor	0.0049	0.0221	0.0176
Echinococcus multilocularis	somatostatin receptor	0.0049	0.0221	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Brugia malayi	putative neuropeptide receptor NPR1	0.0049	0.0221	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Loa Loa (eye worm)	melatonin receptor type 1A	0.0049	0.0221	0.0361
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0049	0.0221	0.0176
Echinococcus granulosus	neuropeptide FF receptor 2	0.0049	0.0221	0.0176
Brugia malayi	hypothetical protein	0.0049	0.0221	0.0361
Schistosoma mansoni	neuropeptide f receptor 76f	0.0049	0.0221	0.0136
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.2982	0.6103
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0049	0.0221	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Schistosoma mansoni	hypothetical protein	0.0049	0.0221	0.0136
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0221	0.0136
Loa Loa (eye worm)	G-protein coupled receptor	0.0049	0.0221	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0221	0.0136
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0221	0.0176
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0221	0.0176
Echinococcus multilocularis	allatostatin A receptor	0.0049	0.0221	0.0176
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0049	0.0221	0.0136
Schistosoma mansoni	amine GPCR	0.0049	0.0221	0.0136
Echinococcus granulosus	neuropeptides capa receptor	0.0049	0.0221	0.0176
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0049	0.0221	0.0136
Loa Loa (eye worm)	neuropeptide F receptor	0.0049	0.0221	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Brugia malayi	G protein-coupled receptor F59B2.13	0.0049	0.0221	0.0361
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0049	0.0221	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Brugia malayi	Dopamine receptor	0.0049	0.0221	0.0361
Schistosoma mansoni	growth hormone secretagogue receptor	0.0049	0.0221	0.0136
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0049	0.0221	0.0176
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0049	0.0221	0.0176
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0049	0.0221	0.0176
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0049	0.0221	0.0136
Echinococcus multilocularis	neuropeptide Y receptor	0.0049	0.0221	0.0176
Schistosoma mansoni	histamine h1 receptor	0.0049	0.0221	0.0136
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0221	0.0176
Echinococcus granulosus	hypothetical protein	0.0049	0.0221	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Schistosoma mansoni	biogenic amine receptor	0.0049	0.0221	0.0136
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0049	0.0221	0.0361
Loa Loa (eye worm)	ceramide glucosyltransferase	0.0288	0.4463	0.9127
Brugia malayi	follicle stimulating hormone receptor	0.0049	0.0221	0.0361
Brugia malayi	ORL1-like opioid receptor	0.0049	0.0221	0.0361
Echinococcus multilocularis	dro:myosuppressin receptor	0.0049	0.0221	0.0176
Schistosoma mansoni	neuropeptide receptor	0.0049	0.0221	0.0136
Schistosoma mansoni	hypothetical protein	0.0049	0.0221	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0221	0.0176
Echinococcus granulosus	microsomal glutathione S transferase 3	0.0115	0.1386	0.1347
Schistosoma mansoni	adenoreceptor	0.0049	0.0221	0.0136
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0221	0.0136
Echinococcus granulosus	ceramide glucosyltransferase	0.0288	0.4463	0.4437
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0049	0.0221	0.0176
Echinococcus granulosus	7tm_1 domain containing protein	0.0049	0.0221	0.0176
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0049	0.0221	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Brugia malayi	hypothetical protein	0.0049	0.0221	0.0361
Brugia malayi	hypothetical protein	0.0049	0.0221	0.0361
Brugia malayi	hypothetical protein	0.0049	0.0221	0.0361
Schistosoma mansoni	neuropeptide receptor	0.0049	0.0221	0.0136
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0049	0.0221	0.0361
Echinococcus multilocularis	serotonin receptor	0.0049	0.0221	0.0176
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0221	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0221	0.0361
Schistosoma mansoni	ceramide glucosyltransferase	0.0288	0.4463	0.5354
Brugia malayi	AKH receptor	0.0049	0.0221	0.0361
Brugia malayi	Dopamine receptor protein 1	0.0049	0.0221	0.0361
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0049	0.0221	0.0176
Brugia malayi	Ceramide glucosyltransferase	0.0288	0.4463	0.9127
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0049	0.0221	0.0176
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.2982	0.6103
Echinococcus multilocularis	neuropeptide receptor	0.0049	0.0221	0.0176
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.2982	0.6103

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 10 nM	Inhibition of GBA2 (unknown origin)	ChEMBL.	25250725
IC50 (binding)	= 125 nM	Inhibition of GBA1 (unknown origin) using beta-D-[1-14C]glucocerebroside assessed as 4-methylumbelliferrone by fluorimetry	ChEMBL.	25250725
IC50 (binding)	= 1.25 uM	Inhibition of glucosylceramide synthase (unknown origin) assessed as catabolism of NBD-glucosylceramide	ChEMBL.	25250725
IC50 (binding)	= 35 uM	Inhibition of intestinal sucrase (unknown origin)	ChEMBL.	25250725
IC50 (binding)	> 100 uM	Inhibition of intestinal lactase (unknown origin)	ChEMBL.	25250725
IC50 (binding)	> 100 uM	Inhibition of intestinal maltase (unknown origin)	ChEMBL.	25250725

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3354620

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 942168