Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0448 | 0.5873 | 0.3163 |
Echinococcus multilocularis | Bromodomain containing protein | 0.0323 | 0.3963 | 0.3963 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0448 | 0.5873 | 0.3163 |
Echinococcus granulosus | CREB binding protein | 0.0442 | 0.579 | 0.579 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0323 | 0.3963 | 0.3605 |
Entamoeba histolytica | bromodomain-containing protein | 0.0323 | 0.3963 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.0101 | 0.0561 | 0.0561 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0717 | 1 | 1 |
Toxoplasma gondii | bromodomain-containing protein | 0.0323 | 0.3963 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0448 | 0.5873 | 0.3163 |
Echinococcus multilocularis | bromodomain containing 2 | 0.0717 | 1 | 1 |
Trichomonas vaginalis | bromodomain containing protein, putative | 0.0448 | 0.5873 | 0.3163 |
Echinococcus granulosus | bromodomain containing 2 | 0.0717 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0717 | 1 | 1 |
Entamoeba histolytica | bromodomain-containing protein | 0.0323 | 0.3963 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.1851 | 0.1367 |
Echinococcus multilocularis | CREB binding protein | 0.0318 | 0.3886 | 0.3886 |
Brugia malayi | Bromodomain containing protein | 0.0717 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0394 | 0.5043 | 0.1789 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0717 | 1 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0448 | 0.5873 | 0.3163 |
Echinococcus granulosus | CREB binding protein | 0.0291 | 0.3468 | 0.3468 |
Brugia malayi | hypothetical protein | 0.0269 | 0.3134 | 0.2726 |
Schistosoma mansoni | bromodomain-containing protein 3 brd3 | 0.0717 | 1 | 1 |
Entamoeba histolytica | bromodomain-containing protein | 0.0323 | 0.3963 | 1 |
Giardia lamblia | Kinase, putative | 0.0323 | 0.3963 | 0.5 |
Onchocerca volvulus | 0.0323 | 0.3963 | 0.5 | |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.0101 | 0.0561 | 0.0561 |
Loa Loa (eye worm) | CBP-B | 0.0322 | 0.3939 | 0.3578 |
Brugia malayi | TAZ zinc finger family protein | 0.0442 | 0.579 | 0.554 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 111 nM | Agonist activity at human recombinant CB2 receptor expressing CHO cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins | ChEMBL. | 25575658 |
EC50 (functional) | > 20000 nM | Agonist activity at human recombinant CB1 receptor expressing CHO cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins | ChEMBL. | 25575658 |
T1/2 (ADMET) | > 120 min | Half life in human liver microsomes at 1 uM in presence of NADPH by LC-MS/MS method | ChEMBL. | 25575658 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.