Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucosidase, beta, acid | Starlite/ChEMBL | References |
Homo sapiens | UDP-glucose ceramide glucosyltransferase | Starlite/ChEMBL | References |
Homo sapiens | glucosidase, beta (bile acid) 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | survival motor neuron protein 1 | 0.0253 | 0.2395 | 0.2526 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.312 | 1 |
Giardia lamblia | Ceramide glucosyltransferase | 0.0131 | 0.0879 | 0.5 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 0.2826 | 0.3364 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0288 | 0.2826 | 0.2826 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.193 | 0.1027 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0251 | 0.2372 | 0.2823 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0365 | 0.0712 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.0251 | 0.2372 | 0.2497 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.312 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0089 | 0.0365 | 0.0435 |
Echinococcus granulosus | bile acid beta glucosidase | 0.0251 | 0.2372 | 0.2497 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0288 | 0.2826 | 0.5166 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0251 | 0.2372 | 0.2823 |
Trichomonas vaginalis | set domain proteins, putative | 0.0254 | 0.24 | 0.4573 |
Onchocerca volvulus | 0.0474 | 0.5128 | 1 | |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0312 | 0.312 | 0.5783 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.2395 | 0.467 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.312 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0088 | 0.0356 | 0.0424 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.312 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.312 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0312 | 0.312 | 0.6084 |
Brugia malayi | hypothetical protein | 0.0253 | 0.2395 | 0.4262 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0205 | 0.1794 | 0.3 |
Brugia malayi | hypothetical protein | 0.0474 | 0.5128 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0739 | 0.84 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0739 | 0.84 | 0.84 |
Loa Loa (eye worm) | hypothetical protein | 0.0474 | 0.5128 | 1 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.0251 | 0.2372 | 0.2372 |
Brugia malayi | Pre-SET motif family protein | 0.0223 | 0.202 | 0.3474 |
Chlamydia trachomatis | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase | 0.0773 | 0.8816 | 0.5 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0739 | 0.84 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.193 | 0.1027 |
Onchocerca volvulus | 0.0254 | 0.24 | 0.4273 | |
Echinococcus multilocularis | bile acid beta glucosidase | 0.0251 | 0.2372 | 0.2372 |
Brugia malayi | Ceramide glucosyltransferase | 0.0288 | 0.2826 | 0.5166 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0253 | 0.2395 | 0.2395 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0126 | 0.0826 | 0.0826 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.1362 | 0.2656 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0288 | 0.2826 | 0.551 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0246 | 0.231 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0474 | 0.5128 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0126 | 0.0826 | 0.0573 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0288 | 0.2826 | 0.3062 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.312 | 1 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0089 | 0.0365 | 0.0365 |
Schistosoma mansoni | lipoxygenase | 0.0126 | 0.0826 | 0.0983 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0223 | 0.202 | 0.3938 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 0.2826 | 0.3364 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4 nM | Inhibition of GBA2 (unknown origin) | ChEMBL. | 25250725 |
IC50 (binding) | = 150 nM | Inhibition of glucosylceramide synthase (unknown origin) assessed as catabolism of NBD-glucosylceramide | ChEMBL. | 25250725 |
IC50 (binding) | = 2 uM | Inhibition of GBA1 (unknown origin) using beta-D-[1-14C]glucocerebroside assessed as 4-methylumbelliferrone by fluorimetry | ChEMBL. | 25250725 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.