Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | alanyl (membrane) aminopeptidase | Starlite/ChEMBL | References |
Sus scrofa | Cytosol aminopeptidase | Starlite/ChEMBL | References |
Homo sapiens | endoplasmic reticulum aminopeptidase 1 | Starlite/ChEMBL | References |
Sus scrofa | Aminopeptidase N | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aminopeptidase N | 0.0328 | 1 | 1 |
Chlamydia trachomatis | cytosol aminopeptidase | 0.0204 | 0.0163 | 0.5 |
Mycobacterium tuberculosis | Probable aminopeptidase PepB | 0.0204 | 0.0163 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 0.6484 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MF, Family M17 | 0.0204 | 0.0163 | 0.5 |
Leishmania major | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 | 0.0204 | 0.0163 | 0.5 |
Plasmodium vivax | M17 leucyl aminopeptidase, putative | 0.0204 | 0.0163 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, Clan MF, Family M17, putative | 0.0204 | 0.0163 | 0.5 |
Toxoplasma gondii | leucyl aminopeptidase LAP | 0.0204 | 0.0163 | 0.5 |
Trypanosoma cruzi | cytosolic leucyl aminopeptidase, putative | 0.0204 | 0.0163 | 0.5 |
Mycobacterium leprae | Probable cytosol aminopeptidase PepB | 0.0204 | 0.0163 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0246 | 0.3516 | 0.5422 |
Plasmodium falciparum | M17 leucyl aminopeptidase | 0.0204 | 0.0163 | 0.5 |
Mycobacterium ulcerans | leucyl aminopeptidase | 0.0204 | 0.0163 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.0328 | 1 | 1 |
Onchocerca volvulus | 0.0328 | 1 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.0204 | 0.0163 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.69 nM | Inhibition of human recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation | ChEMBL. | 25192493 |
Ki (binding) | = 4.2 nM | Inhibition of pig recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation | ChEMBL. | 25192493 |
Ki (binding) | = 138 nM | Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation | ChEMBL. | 25192493 |
Ki (binding) | = 3.73 uM | Inhibition of human ERAP1 preincubated for 30 to 60 mins followed by addition of Leu-AMC as substrate measured for 15 mins by spectrofluorimetric method | ChEMBL. | 27390066 |
Ki (binding) | > 250 uM | Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric method | ChEMBL. | 27390066 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.