Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sucrase-isomaltase (alpha-glucosidase) | Starlite/ChEMBL | References |
Homo sapiens | maltase-glucoamylase (alpha-glucosidase) | Starlite/ChEMBL | References |
Homo sapiens | glucosidase, beta (bile acid) 2 | Starlite/ChEMBL | References |
Homo sapiens | UDP-glucose ceramide glucosyltransferase | Starlite/ChEMBL | References |
Homo sapiens | glucosidase, beta, acid | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.1812 | 0.1027 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 0.4667 | 0.4532 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0288 | 0.4667 | 0.4667 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5605 | 1 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0288 | 0.4667 | 0.4532 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5605 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5605 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.1812 | 0.1027 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0423 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0423 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0423 | 1 | 1 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0288 | 0.4667 | 0.4532 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5605 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0251 | 0.322 | 0.3049 |
Onchocerca volvulus | 0.0284 | 0.4526 | 0.9571 | |
Echinococcus multilocularis | bile acid beta glucosidase | 0.0251 | 0.322 | 0.3049 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.0251 | 0.322 | 0.3049 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0423 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5605 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0423 | 1 | 1 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0288 | 0.4667 | 1 |
Echinococcus granulosus | bile acid beta glucosidase | 0.0251 | 0.322 | 0.3049 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0312 | 0.5605 | 0.5605 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5605 | 1 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.0251 | 0.322 | 0.3049 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0312 | 0.5605 | 0.1759 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0251 | 0.322 | 0.3049 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0423 | 1 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 0.4667 | 0.4532 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 nM | Inhibition of GBA2 (unknown origin) | ChEMBL. | 25250725 |
IC50 (binding) | = 75 nM | Inhibition of glucosylceramide synthase (unknown origin) assessed as catabolism of NBD-glucosylceramide | ChEMBL. | 25250725 |
IC50 (binding) | = 300 nM | Inhibition of GBA1 (unknown origin) using beta-D-[1-14C]glucocerebroside assessed as 4-methylumbelliferrone by fluorimetry | ChEMBL. | 25250725 |
IC50 (binding) | = 0.2 uM | Inhibition of intestinal sucrase (unknown origin) | ChEMBL. | 25250725 |
IC50 (binding) | = 1.5 uM | Inhibition of intestinal maltase (unknown origin) | ChEMBL. | 25250725 |
IC50 (binding) | = 20 uM | Inhibition of intestinal lactase (unknown origin) | ChEMBL. | 25250725 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.