Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 2 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | References |
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0031 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0031 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0031 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0031 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0031 | 1 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0031 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0016 | 0.0808 | 0.0808 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0031 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0031 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0031 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0031 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0031 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0808 | 0.0808 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0031 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0031 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0031 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0808 | 0.0808 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0031 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0808 | 0.0808 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0031 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0031 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0031 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0031 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0031 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0031 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0016 | 0.0808 | 0.0808 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0031 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0016 | 0.0808 | 0.0808 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0031 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0031 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0031 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0031 | 1 | 1 |
Onchocerca volvulus | 0.0031 | 1 | 0.5 | |
Loa Loa (eye worm) | steroid hormone receptor | 0.0031 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0031 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0031 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0031 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0808 | 0.0808 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0031 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0031 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0031 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0031 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0808 | 0.0808 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0031 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0031 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0031 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0031 | 1 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0031 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0808 | 0.0808 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0031 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0031 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0031 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0016 | 0.0808 | 0.0808 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0031 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0808 | 0.0808 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CLH (ADMET) | = 72 % | Clearance in human liver microsomes after 60 mins by HPLC analysis relative to hepatic blood flow | ChEMBL. | 25516791 |
Emax (binding) | = 92 % | Agonist activity at GR in HFF cells assessed as suppression of IL-1-induced IL-6 production at 2 uM relative to dexamethasone | ChEMBL. | 25516791 |
IC50 (binding) | = 45 nM | Agonist activity at GR in HFF cells assessed as suppression of IL-1-induced IL-6 production | ChEMBL. | 25516791 |
IC50 (binding) | = 110 nM | Displacement of RU-486 from GR (unknown origin) by fluorescence polarization assay | ChEMBL. | 25516791 |
IC50 (binding) | > 2000 nM | Displacement of tetramethylrhodamine-labeled dexamethasone from PR (unknown origin) by fluorescence polarization assay | ChEMBL. | 25516791 |
IC50 (binding) | > 2000 nM | Displacement of RU-486 from MR (unknown origin) by fluorescence polarization assay | ChEMBL. | 25516791 |
IC50 (ADMET) | = 6 uM | Inhibition of human recombinant CYP3A4 using 7-benzyloxy-4-(trifluoromethyl)-coumarin as substrate after 30 mins by fluorescence assay | ChEMBL. | 25516791 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.