Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinase insert domain receptor | Starlite/ChEMBL | References |
Homo sapiens | polo-like kinase 4 | Starlite/ChEMBL | References |
Homo sapiens | fms-related tyrosine kinase 3 | Starlite/ChEMBL | References |
Homo sapiens | aurora kinase B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | aurora kinase B | 303 aa | 299 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.003 | 0.1192 | 0.182 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0203 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1192 | 0.1192 |
Echinococcus multilocularis | neuroglian | 0.0033 | 0.1339 | 0.2043 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0068 | 0.3154 | 1 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0068 | 0.3154 | 0.5 |
Brugia malayi | Fibronectin type III domain containing protein | 0.003 | 0.1192 | 0.1192 |
Echinococcus multilocularis | roundabout 2 | 0.0036 | 0.1525 | 0.2327 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0007 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1192 | 0.1192 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0068 | 0.3154 | 0.4813 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1192 | 0.1192 |
Schistosoma mansoni | kinase | 0.0193 | 0.9484 | 1 |
Echinococcus granulosus | twitchin | 0.0034 | 0.1386 | 0.2115 |
Trichomonas vaginalis | AGC family protein kinase | 0.0068 | 0.3154 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0068 | 0.3154 | 1 |
Echinococcus granulosus | aurora kinase A | 0.0068 | 0.3154 | 0.4813 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.003 | 0.1192 | 0.1257 |
Brugia malayi | serine/threonine kinase 12 | 0.0068 | 0.3154 | 0.3154 |
Trypanosoma brucei | aurora B kinase | 0.0068 | 0.3154 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0068 | 0.3154 | 0.4813 |
Echinococcus granulosus | defective proboscis extension response | 0.003 | 0.1192 | 0.182 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1192 | 0.1192 |
Entamoeba histolytica | protein kinase, putative | 0.0068 | 0.3154 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0068 | 0.3154 | 1 |
Onchocerca volvulus | 0.0167 | 0.815 | 0.9663 | |
Trichomonas vaginalis | AGC family protein kinase | 0.0068 | 0.3154 | 1 |
Schistosoma mansoni | protein kinase | 0.0068 | 0.3154 | 0.3325 |
Echinococcus multilocularis | Immunoglobulin | 0.003 | 0.1192 | 0.182 |
Echinococcus multilocularis | aurora kinase A | 0.0068 | 0.3154 | 0.4813 |
Entamoeba histolytica | protein kinase, putative | 0.0068 | 0.3154 | 1 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0068 | 0.3154 | 0.3154 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1525 | 0.1525 |
Echinococcus granulosus | roundabout 2 | 0.0036 | 0.1525 | 0.2327 |
Schistosoma mansoni | vesicular amine transporter | 0.003 | 0.1192 | 0.1257 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0059 | 0.2646 | 0.279 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0059 | 0.2646 | 0.4039 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0068 | 0.3154 | 0.3325 |
Trichomonas vaginalis | AGC family protein kinase | 0.0068 | 0.3154 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0068 | 0.3154 | 1 |
Entamoeba histolytica | protein kinase , putative | 0.0068 | 0.3154 | 1 |
Echinococcus granulosus | neuroglian | 0.0033 | 0.1339 | 0.2043 |
Brugia malayi | hypothetical protein | 0.003 | 0.1192 | 0.1192 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0059 | 0.2646 | 0.4039 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0059 | 0.2646 | 0.2646 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1379 | 0.1379 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0172 | 0.8435 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1525 | 0.1525 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.003 | 0.1192 | 0.1257 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0059 | 0.2646 | 0.3138 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0068 | 0.3154 | 0.5 |
Echinococcus granulosus | Immunoglobulin | 0.003 | 0.1192 | 0.182 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0068 | 0.3154 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0068 | 0.3154 | 0.3154 |
Schistosoma mansoni | cell adhesion molecule | 0.0034 | 0.1379 | 0.1454 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0059 | 0.2646 | 0.2646 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1192 | 0.1192 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0068 | 0.3154 | 0.3154 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0034 | 0.1379 | 0.2104 |
Toxoplasma gondii | aurora kinase | 0.0068 | 0.3154 | 0.5 |
Echinococcus multilocularis | Immunoglobulin | 0.003 | 0.1192 | 0.182 |
Loa Loa (eye worm) | AUR protein kinase | 0.0068 | 0.3154 | 0.3154 |
Leishmania major | protein kinase, putative | 0.0068 | 0.3154 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1192 | 0.1192 |
Schistosoma mansoni | tyrosine kinase | 0.0009 | 0.0139 | 0.0146 |
Echinococcus granulosus | Serine:threonine protein kinase PLK4 | 0.0135 | 0.6552 | 1 |
Schistosoma mansoni | nephrin | 0.0033 | 0.1339 | 0.1411 |
Echinococcus multilocularis | Serine:threonine protein kinase PLK4 | 0.0135 | 0.6552 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0068 | 0.3154 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.003 | 0.1192 | 0.1192 |
Loa Loa (eye worm) | AUR protein kinase | 0.0068 | 0.3154 | 0.3154 |
Giardia lamblia | Aurora kinase | 0.0068 | 0.3154 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 0.025 uM | Cytotoxicity against human MCF7 cells after 5 days by SRB assay | ChEMBL. | 24867403 |
IC50 (binding) | = 2.6 nM | Inhibition of human N-terminal GST-tagged PLK4 (1 to 391 residues) expressed in Escherichia coli incubated for 30 mins by ELISA method | ChEMBL. | 24867403 |
IC50 (binding) | = 32 nM | Inhibition of FLT3 (unknown origin) by FRET-based homogeneous assay | ChEMBL. | 24867403 |
IC50 (binding) | = 33 nM | Inhibition of AURKB (unknown origin) by FRET-based homogeneous assay | ChEMBL. | 24867403 |
IC50 (binding) | = 4900 nM | Inhibition of KDR (unknown origin) by FRET-based homogeneous assay | ChEMBL. | 24867403 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.