Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | chemokine (C-C motif) receptor 3 | Starlite/ChEMBL | References |
Homo sapiens | chemokine (C-C motif) receptor 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | chemokine (C-C motif) receptor 3 | 359 aa | 338 aa | 23.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Deoxynucleoside kinase | 0.138 | 0.1193 | 1 |
Brugia malayi | Deoxynucleoside kinase family protein | 0.0977 | 0 | 0.5 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0977 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0977 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0977 | 0 | 0.5 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0977 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0977 | 0 | 0.5 |
Echinococcus granulosus | thymidine kinase | 0.436 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0977 | 0 | 0.5 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0977 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0977 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0977 | 0 | 0.5 |
Echinococcus granulosus | Thymidine kinase 2 mitochondrial | 0.436 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0977 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0977 | 0 | 0.5 |
Echinococcus multilocularis | thymidine kinase | 0.436 | 1 | 1 |
Schistosoma mansoni | thymidine kinase | 0.436 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0977 | 0 | 0.5 |
Echinococcus multilocularis | thymidine kinase | 0.436 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0977 | 0 | 0.5 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0977 | 0 | 0.5 |
Echinococcus multilocularis | transfer RNA-Ile | 0.436 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0977 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0977 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0977 | 0 | 0.5 |
Loa Loa (eye worm) | deoxynucleoside kinase | 0.0977 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0977 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells | ChEMBL. | 25497216 | |
Ki (binding) | = 310 nM | Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells | ChEMBL. | 25497216 |
Ki (binding) | = 380 nM | Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells | ChEMBL. | 25497216 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.