Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, theta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132502 | All targets in OG5_132502 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132502 | All targets in OG5_132502 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132502 | All targets in OG5_132502 |
Onchocerca volvulus | Get druggable targets OG5_132502 | All targets in OG5_132502 | |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132502 | All targets in OG5_132502 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132502 | All targets in OG5_132502 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | expressed protein | 0.0106 | 0.5565 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0022 | 0.0563 | 0.0985 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0103 | 0.5416 | 1 |
Trichomonas vaginalis | rotamase, putative | 0.0103 | 0.5416 | 0.9732 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0032 | 0.1166 | 0.2128 |
Trichomonas vaginalis | AGC family protein kinase | 0.0013 | 0.0017 | 0.003 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0022 | 0.0563 | 0.0985 |
Echinococcus granulosus | expressed protein | 0.0106 | 0.5565 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.9774 | 0.9773 |
Trichomonas vaginalis | AGC family protein kinase | 0.0013 | 0.0017 | 0.003 |
Echinococcus granulosus | protein kinase c iota type | 0.0022 | 0.0563 | 0.0985 |
Trichomonas vaginalis | AGC family protein kinase | 0.0013 | 0.0017 | 0.003 |
Schistosoma mansoni | atypical protein kinase C | 0.0022 | 0.0563 | 0.0985 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0106 | 0.5565 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0013 | 0.0017 | 0.003 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0103 | 0.5416 | 1 |
Brugia malayi | protein kinase C II. | 0.0022 | 0.0563 | 0.0985 |
Trichomonas vaginalis | AGC family protein kinase | 0.0013 | 0.0017 | 0.003 |
Trichomonas vaginalis | AGC family protein kinase | 0.0013 | 0.0017 | 0.003 |
Trichomonas vaginalis | AGC family protein kinase | 0.0013 | 0.0017 | 0.003 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0106 | 0.5565 | 0.5557 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0103 | 0.5416 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0022 | 0.0563 | 0.0985 |
Trichomonas vaginalis | AGC family protein kinase | 0.0013 | 0.0017 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.9227 | 0.9226 |
Onchocerca volvulus | 0.0167 | 0.9227 | 0.5 | |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0106 | 0.5565 | 1 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0103 | 0.5416 | 1 |
Schistosoma mansoni | rotamase | 0.0106 | 0.5565 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0022 | 0.0563 | 0.0547 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0022 | 0.0563 | 0.0985 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0022 | 0.0563 | 0.0985 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.9227 | 0.9226 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.9227 | 0.9226 |
Trichomonas vaginalis | AGC family protein kinase | 0.0013 | 0.0017 | 0.003 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0103 | 0.5416 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0013 | 0.0017 | 0.003 |
Echinococcus multilocularis | protein kinase c iota type | 0.0022 | 0.0563 | 0.0985 |
Trichomonas vaginalis | rotamase, putative | 0.0106 | 0.5565 | 1 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0022 | 0.0563 | 0.0985 |
Toxoplasma gondii | PPIC-type PPIASE domain-containing protein | 0.0032 | 0.1166 | 0.2128 |
Wolbachia endosymbiont of Brugia malayi | parvulin-like peptidyl-prolyl isomerase, PPID | 0.0032 | 0.1166 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0013 | 0.0017 | 0.003 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0103 | 0.5416 | 1 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0022 | 0.0563 | 0.0985 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.5 uM | Inhibition of human recombinant PKCtheta expressed in Sf21 cells using Bio-cdc peptide substrate and ATP after 60 mins by time-resolved fluorescence in-vitro kinase assay | ChEMBL. | 25000588 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.