Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.019 | 0.6426 | 0.5758 |
Trypanosoma cruzi | oligopeptidase b | 0.0103 | 0.1943 | 0.0437 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0103 | 0.1943 | 0.0437 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 1 | 1 |
Trypanosoma cruzi | prolyl endopeptidase | 0.026 | 1 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.026 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.026 | 1 | 1 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.026 | 1 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0233 | 0.8597 | 0.8331 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 0.1574 | 0.5 |
Echinococcus multilocularis | prolyl endopeptidase | 0.026 | 1 | 1 |
Trypanosoma cruzi | oligopeptidase b | 0.0103 | 0.1943 | 0.0437 |
Toxoplasma gondii | prolyl endopeptidase | 0.026 | 1 | 1 |
Trypanosoma brucei | oligopeptidase b | 0.0103 | 0.1943 | 0.0437 |
Echinococcus granulosus | geminin | 0.019 | 0.6426 | 0.5758 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.1574 | 0.1574 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0103 | 0.1943 | 0.0437 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0103 | 0.1943 | 0.0437 |
Plasmodium vivax | hexokinase, putative | 0.0096 | 0.1574 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.1574 | 0.1574 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.026 | 1 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0096 | 0.1574 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.6426 | 0.5758 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 0.1574 | 0.1574 |
Plasmodium falciparum | hexokinase | 0.0096 | 0.1574 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 0.1574 | 0.5 |
Trypanosoma brucei | prolyl endopeptidase | 0.026 | 1 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0103 | 0.1943 | 0.5 |
Echinococcus multilocularis | geminin | 0.019 | 0.6426 | 0.5758 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0103 | 0.1943 | 0.5 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0103 | 0.1943 | 0.0437 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0259 | 0.993 | 1 |
Leishmania major | oligopeptidase b | 0.0103 | 0.1943 | 0.0437 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0103 | 0.1943 | 0.0437 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 16.8 uM | Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose | ChEMBL. | 25516785 |
Km (binding) | = 1.2 mM | Activity of human recombinant Glucokinase measured over 5 mins by spectrophotometry | ChEMBL. | 25516785 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.