Detailed information for compound 947133

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 362.425 | Formula: C21H22N4O2
  • H donors: 0 H acceptors: 2 LogP: 2.74 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(n1cncc1)N1CCN(CC1)Cc1cccc(c1)Oc1ccccc1
  • InChi: 1S/C21H22N4O2/c26-21(25-10-9-22-17-25)24-13-11-23(12-14-24)16-18-5-4-8-20(15-18)27-19-6-2-1-3-7-19/h1-10,15,17H,11-14,16H2
  • InChiKey: LUVFYELCNQAENZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens fatty acid amide hydrolase Starlite/ChEMBL References
Homo sapiens monoglyceride lipase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni amidase Get druggable targets OG5_127783 All targets in OG5_127783
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans similar to YJU3 Get druggable targets OG5_127037 All targets in OG5_127037
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma mansoni fatty-acid amide hydrolase Get druggable targets OG5_127783 All targets in OG5_127783
Trypanosoma brucei monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum esterase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania braziliensis monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma cruzi monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium vivax PST-A protein Get druggable targets OG5_127037 All targets in OG5_127037
Echinococcus multilocularis fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Mycobacterium ulcerans lysophospholipase Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei gambiense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma japonicum ko:K01175 fatty acid amide hydrolase [EC:3.1.-.-], putative Get druggable targets OG5_127783 All targets in OG5_127783
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Echinococcus granulosus fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei gambiense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Brugia malayi amidase Get druggable targets OG5_127783 All targets in OG5_127783
Leishmania major monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Leishmania donovani monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania infantum monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans similar to YJU3 Get druggable targets OG5_127037 All targets in OG5_127037
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
Echinococcus granulosus fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus multilocularis fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania mexicana monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis valacyclovir hydrolase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Mycobacterium tuberculosis Possible lysophospholipase Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum esterase, putative monoglyceride lipase 303 aa 254 aa 19.7 %
Leishmania major hypothetical protein, conserved fatty acid amide hydrolase 579 aa 471 aa 26.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0321 0.4179 0.7158
Leishmania major DNA polymerase eta, putative 0.0034 0.0233 0.207
Loa Loa (eye worm) hypothetical protein 0.0037 0.0271 0.0465
Brugia malayi Niemann-Pick C1 protein precursor 0.0106 0.1226 0.204
Leishmania major DNA polymerase eta, putative 0.0048 0.043 0.4334
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0052 0.0052
Schistosoma mansoni aryl hydrocarbon receptor 0.0096 0.1081 0.1081
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0084 0.0924 0.7425
Echinococcus multilocularis expressed conserved protein 0.01 0.1138 0.1138
Loa Loa (eye worm) hypothetical protein 0.0056 0.0534 0.0914
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0052 0.0052
Brugia malayi CHE-14 protein 0.0046 0.0393 0.0653
Loa Loa (eye worm) hypothetical protein 0.0026 0.0118 0.0202
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0108 0.0639
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0924 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0108 0.0639
Loa Loa (eye worm) hypothetical protein 0.0048 0.043 0.0737
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0108 0.0639
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0052 0.0416
Echinococcus granulosus expressed conserved protein 0.01 0.1138 0.1138
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0118 0.0557
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0052 0.009
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0118 0.0557
Brugia malayi ImpB/MucB/SamB family protein 0.0048 0.043 0.0716
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0118 0.0196
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.0108 0.0639
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0123 0.1458 0.1458
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0025 0.0108 1
Echinococcus multilocularis microtubule associated protein 2 0.0745 1 1
Schistosoma mansoni hypothetical protein 0.0044 0.037 0.037
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0393 0.0673
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0393 0.0393
Mycobacterium ulcerans hypothetical protein 0.0026 0.0118 0.0993
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0108 0.0639
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0108 0.0639
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0118 0.0196
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0118 0.1135
Echinococcus granulosus fatty acid amide hydrolase 1 0.0123 0.1458 0.1458
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0108 0.0639
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0393 0.3905
Onchocerca volvulus 0.0026 0.0118 0.0021
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0118 0.0993
Mycobacterium ulcerans hypothetical protein 0.0084 0.0924 1
Echinococcus granulosus jun protein 0.0454 0.601 0.601
Loa Loa (eye worm) hypoxia-induced factor 1 0.0296 0.3837 0.6572
Echinococcus multilocularis jun protein 0.0454 0.601 0.601
Leishmania major monoglyceride lipase, putative 0.0084 0.0924 1
Trypanosoma brucei DNA polymerase eta, putative 0.0048 0.043 0.4334
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0505 0.0841
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0084 0.0924 0.7425
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0052 0.0262
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0025 0.0108 0.0639
Loa Loa (eye worm) hypothetical protein 0.0026 0.0118 0.0202
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0084 0.0924 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.0924 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0118 0.075
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0108 0.1249 0.1249
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0025 0.0108 0.0185
Echinococcus multilocularis transfer RNA-Lys 0.0071 0.074 0.074
Echinococcus granulosus Niemann Pick C1 protein 0.0106 0.1226 0.1226
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0118 0.0993
Schistosoma mansoni hypothetical protein 0.0369 0.484 0.484
Schistosoma mansoni microtubule-associated protein tau 0.0745 1 1
Echinococcus granulosus single minded 2 0.0071 0.074 0.074
Leishmania major protein kinase, putative 0.0025 0.0108 0.0639
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0118 0.1135
Mycobacterium ulcerans putative regulatory protein 0.0071 0.074 0.7941
Brugia malayi bZIP transcription factor family protein 0.0454 0.601 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0152 0.1853 0.1853
Schistosoma mansoni single-minded 0.0096 0.1081 0.1081
Schistosoma mansoni hypothetical protein 0.0044 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0123 0.1458 0.2497
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.0049
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.0924 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.0049
Plasmodium falciparum lysophospholipase, putative 0.0084 0.0924 1
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0271 0.0452
Trypanosoma brucei monoglyceride lipase, putative 0.0084 0.0924 1
Plasmodium falciparum lysophospholipase, putative 0.0084 0.0924 1
Brugia malayi hypothetical protein 0.0357 0.4669 0.7769
Plasmodium vivax PST-A protein 0.0084 0.0924 1
Schistosoma mansoni patched 1 0.0046 0.0393 0.0393
Loa Loa (eye worm) hypothetical protein 0.0026 0.0118 0.0202
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0118 0.0993
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0108 0.0639
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0118 0.0993
Plasmodium falciparum lysophospholipase, putative 0.0084 0.0924 1
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0393 0.0393
Echinococcus multilocularis Niemann Pick C1 protein 0.0106 0.1226 0.1226
Echinococcus multilocularis aryl hydrocarbon receptor 0.0025 0.0108 0.0108
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0505 0.0866
Brugia malayi PAS domain containing protein 0.0096 0.1081 0.18
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0108 0.0639
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.0924 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0118 0.0119
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0106 0.1226 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0108 0.0185
Loa Loa (eye worm) hypothetical protein 0.0054 0.0505 0.0866
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0084 0.0924 1
Trypanosoma brucei monoglyceride lipase, putative 0.0084 0.0924 1
Echinococcus multilocularis protein patched 0.0046 0.0393 0.0393
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0108 0.0639
Schistosoma mansoni hypothetical protein 0.0037 0.0271 0.0271
Schistosoma mansoni fatty-acid amide hydrolase 0.0123 0.1458 0.1458
Onchocerca volvulus 0.0071 0.074 0.1385
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0118 0.075
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0108 0.0639
Plasmodium falciparum esterase, putative 0.0084 0.0924 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.0233 0.207
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.0108 0.0639
Schistosoma mansoni amidase 0.0123 0.1458 0.1458
Leishmania major protein kinase, putative 0.0025 0.0108 0.0639
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0052 0.0052
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.0924 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.0049
Trypanosoma cruzi monoglyceride lipase, putative 0.0084 0.0924 1
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0025 0.0108 0.0639
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0505 0.0841
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0123 0.1458 0.1458
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.0049
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0118 0.0993
Brugia malayi hypoxia-induced factor 1 0.0296 0.3837 0.6385
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0052 0.0262
Loa Loa (eye worm) hypothetical protein 0.0442 0.5839 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0052 0.0052
Echinococcus granulosus dna polymerase eta 0.0048 0.043 0.043
Echinococcus granulosus aryl hydrocarbon receptor 0.0025 0.0108 0.0108
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0025 0.0108 0.0108
Mycobacterium ulcerans lysophospholipase 0.0084 0.0924 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0118 0.075
Echinococcus multilocularis protein dispatched 1 0.0052 0.0481 0.0481
Echinococcus granulosus dna polymerase kappa 0.0021 0.0052 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0924 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0052 0.0052
Schistosoma mansoni jun-related protein 0.0369 0.484 0.484
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0454 0.601 0.601
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0108 0.0639
Giardia lamblia DINP protein human, muc B family 0.0021 0.0052 0.5
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0025 0.0108 0.0108
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0052 0.0416
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0108 0.0639
Echinococcus granulosus fatty acid amide hydrolase 1 0.0123 0.1458 0.1458
Onchocerca volvulus 0.0357 0.4669 1
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0108 0.0639
Schistosoma mansoni DNA polymerase eta 0.0048 0.043 0.043
Echinococcus multilocularis dna polymerase eta 0.0048 0.043 0.043
Brugia malayi amidase 0.0123 0.1458 0.2426
Schistosoma mansoni hypothetical protein 0.0044 0.037 0.037
Echinococcus granulosus Niemann Pick C1 protein 0.0152 0.1853 0.1853
Schistosoma mansoni hypothetical protein 0.0044 0.037 0.037
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0029 0.0158
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0118 0.0993
Brugia malayi bHLH-PAS transcription factor 0.0071 0.074 0.1231
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0118 0.0993
Loa Loa (eye worm) hypothetical protein 0.0106 0.1226 0.21
Brugia malayi hypothetical protein 0.0321 0.4179 0.6954
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0118 0.0119
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.0233 0.5
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0108 0.0639
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0118 0.0196
Mycobacterium tuberculosis Possible lysophospholipase 0.0084 0.0924 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0393 0.0673
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.043 0.4334
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0052 0.0087
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.0924 1
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0393 0.0393
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0118 0.0557
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0454 0.601 0.601

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.55 Inhibition of human recombinant MAGL expressed in HEK293 cells using 2-AG as substrate ChEMBL. 25282655
IC50 (binding) = 7.81 Inhibition of human recombinant FAAH expressed in COS7 cells using anandamide as substrate ChEMBL. 25282655
IC50 (binding) = 15 nM Inhibition of human recombinant FAAH expressed in COS7 cells using anandamide as substrate ChEMBL. 25282655
IC50 (binding) = 2844 nM Inhibition of human recombinant MAGL expressed in HEK293 cells using 2-AG as substrate ChEMBL. 25282655

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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