Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | alpha/beta hydrolase, putative | 0.0306 | 0.0579 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0252 | 0.0438 | 0.0822 |
Mycobacterium tuberculosis | 4,9-DHSA hydrolase | 0.381 | 0.9816 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0306 | 0.0579 | 0.1183 |
Trypanosoma brucei | Alpha/beta hydrolase family, putative | 0.0252 | 0.0438 | 0.0822 |
Mycobacterium tuberculosis | Possible hydrolase | 0.0252 | 0.0438 | 0.0446 |
Brugia malayi | hydrolase, alpha/beta fold family protein | 0.0252 | 0.0438 | 0.0822 |
Trichomonas vaginalis | lipase containing protein, putative | 0.1615 | 0.4031 | 0.5 |
Onchocerca volvulus | 0.1615 | 0.4031 | 0.5 | |
Echinococcus granulosus | abhydrolase domain containing protein 11 | 0.0306 | 0.0579 | 0.1183 |
Toxoplasma gondii | hydrolase, alpha/beta fold family protein | 0.0252 | 0.0438 | 1 |
Loa Loa (eye worm) | lipase | 0.1615 | 0.4031 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.1615 | 0.4031 | 1 |
Schistosoma mansoni | family S33 non-peptidase homologue (S33 family) | 0.0306 | 0.0579 | 1 |
Echinococcus multilocularis | abhydrolase domain containing protein 11 | 0.0306 | 0.0579 | 0.1183 |
Trichomonas vaginalis | lipase containing protein, putative | 0.1615 | 0.4031 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1615 | 0.4031 | 1 |
Trypanosoma cruzi | Alpha/beta hydrolase family, putative | 0.0252 | 0.0438 | 0.0822 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.1615 | 0.4031 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1615 | 0.4031 | 1 |
Wolbachia endosymbiont of Brugia malayi | esterase | 0.013 | 0.0116 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase family, putative | 0.0252 | 0.0438 | 0.0822 |
Chlamydia trachomatis | lysophospholipase esterase | 0.013 | 0.0116 | 0.5 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.1615 | 0.4031 | 1 |
Leishmania major | hypothetical protein, conserved | 0.1615 | 0.4031 | 1 |
Plasmodium vivax | alpha/beta hydrolase, putative | 0.0306 | 0.0579 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.1615 | 0.4031 | 1 |
Brugia malayi | Lipase family protein | 0.1615 | 0.4031 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 92 % | Inhibition of human recombinant MAGL expressed in HEK293 cells using 2-AG as substrate assessed as remaining activity at 10 uM | ChEMBL. | 25282655 |
Activity (binding) | = 92 % | Inhibition of human recombinant FAAH expressed in COS7 cells using anandamide as substrate assessed as remaining activity at 10 uM | ChEMBL. | 25282655 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.