Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 2 | Starlite/ChEMBL | References |
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0031 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0031 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0808 | 0.0808 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0031 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0031 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0016 | 0.0808 | 0.0808 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0808 | 0.0808 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0808 | 0.0808 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0031 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0016 | 0.0808 | 0.0808 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0031 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0031 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0031 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0031 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0031 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0031 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0031 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0808 | 0.0808 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0031 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0031 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0031 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0031 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0031 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0015 | 0 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0031 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0031 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0031 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0031 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0808 | 0.0808 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0031 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0031 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0031 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0016 | 0.0808 | 0.0808 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0031 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0031 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0031 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0031 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0031 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0031 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0031 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0808 | 0.0808 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0031 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0031 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0031 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0031 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0031 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0808 | 0.0808 |
Brugia malayi | nuclear hormone receptor | 0.0031 | 1 | 1 |
Onchocerca volvulus | 0.0031 | 1 | 0.5 | |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0031 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0016 | 0.0808 | 0.0808 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0031 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0031 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CLH (ADMET) | = 62 % | Clearance in human liver microsomes after 60 mins by HPLC analysis relative to hepatic blood flow | ChEMBL. | 25516791 |
Emax (binding) | = 95 % | Agonist activity at GR in HFF cells assessed as suppression of IL-1-induced IL-6 production at 2 uM relative to dexamethasone | ChEMBL. | 25516791 |
IC50 (binding) | = 2 nM | Agonist activity at GR in HFF cells assessed as suppression of IL-1-induced IL-6 production | ChEMBL. | 25516791 |
IC50 (binding) | = 10 nM | Displacement of RU-486 from GR (unknown origin) by fluorescence polarization assay | ChEMBL. | 25516791 |
IC50 (binding) | > 2000 nM | Displacement of tetramethylrhodamine-labeled dexamethasone from PR (unknown origin) by fluorescence polarization assay | ChEMBL. | 25516791 |
IC50 (binding) | > 2000 nM | Displacement of RU-486 from MR (unknown origin) by fluorescence polarization assay | ChEMBL. | 25516791 |
IC50 (ADMET) | = 0.01 uM | Inhibition of human recombinant CYP3A4 using 7-benzyloxy-4-(trifluoromethyl)-coumarin as substrate after 30 mins by fluorescence assay | ChEMBL. | 25516791 |
IC50 (binding) | = 20 uM | Inhibition of human ERG channel expressed in recombinant HEK293 cells by whole cell patch-clamp technique | ChEMBL. | 25516791 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.