Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | DNA gyrase, subunit B | References | |
Escherichia coli | DNA gyrase (type II topoisomerase), subunit A | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | mitochondrial DNA topoisomerase II | 0.0121 | 0.0464 | 0.0431 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0121 | 0.0464 | 0.0431 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0318 | 0.1792 | 1 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0318 | 0.1792 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0318 | 0.1792 | 1 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.1185 | 0.765 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0783 | 0.4937 | 0.4882 |
Giardia lamblia | DNA topoisomerase II | 0.0064 | 0.0076 | 0.5 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0152 | 0.0668 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0121 | 0.0464 | 0.0431 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0153 | 0.0677 | 0.3378 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0318 | 0.1792 | 1 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0318 | 0.1792 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1533 | 1 | 1 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.1185 | 0.765 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0153 | 0.0677 | 0.2419 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0121 | 0.0464 | 0.0431 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0153 | 0.0677 | 0.3378 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0069 | 0.0109 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.1185 | 0.765 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0069 | 0.0109 | 0.5 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0318 | 0.1792 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1533 | 1 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.1185 | 0.765 | 0.7624 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0318 | 0.1792 | 1 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0318 | 0.1792 | 1 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.1185 | 0.765 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1533 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1533 | 1 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0088 | 0.0241 | 0.0788 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.1185 | 0.765 | 0.7624 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Fu (ADMET) | = 5.2 % | Fraction unbound in human plasma at 10 uM after 16 hrs by LC-MS/MS analysis | ChEMBL. | 25286019 |
IC50 (binding) | = 0.34 uM | Inhibition of Escherichia coli DNA gyrase using fluorescence-tagged DNA by fluorescenct polarization assay | ChEMBL. | 25286019 |
MIC (functional) | <= 0.2 uM | Antimicrobial activity against tolC-deficient Escherichia coli by broth microdilution method | ChEMBL. | 25286019 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.