Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0073 | 0.2986 | 0.2986 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0073 | 0.2986 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0062 | 0.2034 | 0.6811 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0073 | 0.2986 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0073 | 0.2986 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0073 | 0.2986 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0062 | 0.2034 | 0.6811 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0073 | 0.2986 | 0.2986 |
Brugia malayi | endonuclease G, mitochondrial precursor | 0.0044 | 0.0569 | 0.0569 |
Echinococcus multilocularis | Endonuclease G | 0.0044 | 0.0569 | 0.1905 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0073 | 0.2986 | 1 |
Trypanosoma brucei | endonuclease G, putative | 0.0044 | 0.0569 | 0.5 |
Trypanosoma cruzi | endonuclease G, putative | 0.0044 | 0.0569 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.0044 | 0.0569 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0073 | 0.2986 | 0.2986 |
Leishmania major | endonuclease G, putative | 0.0044 | 0.0569 | 0.5 |
Trypanosoma cruzi | endonuclease G, putative | 0.0044 | 0.0569 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0073 | 0.2986 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0073 | 0.2986 | 1 |
Echinococcus multilocularis | ectonucleotide | 0.0062 | 0.2034 | 0.6811 |
Schistosoma mansoni | hypothetical protein | 0.0158 | 1 | 1 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0044 | 0.0569 | 0.5 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2986 | 0.1195 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0044 | 0.0569 | 0.5 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0044 | 0.0569 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0073 | 0.2986 | 0.2986 |
Trypanosoma brucei | endonuclease G, putative | 0.0044 | 0.0569 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0073 | 0.2986 | 0.2986 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0073 | 0.2986 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0073 | 0.2986 | 1 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0044 | 0.0569 | 0.5 |
Echinococcus granulosus | Endonuclease G | 0.0044 | 0.0569 | 0.1905 |
Echinococcus granulosus | ectonucleotide | 0.0062 | 0.2034 | 0.6811 |
Schistosoma mansoni | endonuclease related | 0.0044 | 0.0569 | 0.0569 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2986 | 0.1195 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0073 | 0.2986 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2986 | 0.1195 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0073 | 0.2986 | 1 |
Onchocerca volvulus | 0.0158 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 100 % | Inhibition of amyloid beta-42 self-aggregation (unknown origin) at 25 uM after 20 hrs by ThT fluorescence assay | ChEMBL. | 25467149 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.