Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0073 | 0.2986 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0073 | 0.2986 | 1 |
Echinococcus multilocularis | Endonuclease G | 0.0044 | 0.0569 | 0.1905 |
Trypanosoma brucei | endonuclease G, putative | 0.0044 | 0.0569 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0073 | 0.2986 | 1 |
Echinococcus granulosus | Endonuclease G | 0.0044 | 0.0569 | 0.1905 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0044 | 0.0569 | 0.5 |
Leishmania major | endonuclease G, putative | 0.0044 | 0.0569 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2986 | 0.1195 |
Echinococcus granulosus | ectonucleotide | 0.0062 | 0.2034 | 0.6811 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0073 | 0.2986 | 0.2986 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0044 | 0.0569 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0073 | 0.2986 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0073 | 0.2986 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0062 | 0.2034 | 0.6811 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0073 | 0.2986 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.0044 | 0.0569 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0073 | 0.2986 | 0.2986 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0073 | 0.2986 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2986 | 0.1195 |
Schistosoma mansoni | hypothetical protein | 0.0158 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0073 | 0.2986 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0073 | 0.2986 | 0.2986 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2986 | 0.1195 |
Trypanosoma cruzi | endonuclease G, putative | 0.0044 | 0.0569 | 0.5 |
Echinococcus multilocularis | ectonucleotide | 0.0062 | 0.2034 | 0.6811 |
Schistosoma mansoni | endonuclease related | 0.0044 | 0.0569 | 0.0569 |
Onchocerca volvulus | 0.0158 | 1 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0073 | 0.2986 | 0.2986 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0073 | 0.2986 | 1 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0044 | 0.0569 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0044 | 0.0569 | 0.5 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0158 | 1 | 1 |
Trypanosoma brucei | endonuclease G, putative | 0.0044 | 0.0569 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0073 | 0.2986 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0062 | 0.2034 | 0.6811 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0073 | 0.2986 | 0.2986 |
Brugia malayi | endonuclease G, mitochondrial precursor | 0.0044 | 0.0569 | 0.0569 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0073 | 0.2986 | 1 |
Trypanosoma cruzi | endonuclease G, putative | 0.0044 | 0.0569 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 46 % | Inhibition of amyloid beta-42 self-aggregation (unknown origin) at 25 uM after 20 hrs by ThT fluorescence assay | ChEMBL. | 25467149 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.