Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0165143 | 0.0100088 | 0.0241731 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0145871 | 0 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.0165143 | 0.0100088 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0165143 | 0.0100088 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0165143 | 0.0100088 | 0.0100088 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.19255 | 0.924242 | 1 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.094312 | 0.414048 | 1 |
Onchocerca volvulus | 0.0145871 | 0 | 0.5 | |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.207137 | 1 | 1 |
Echinococcus multilocularis | 0.0145871 | 0 | 0.5 | |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0165143 | 0.0100088 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0165143 | 0.0100088 | 0.0241731 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0165143 | 0.0100088 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145871 | 0 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0145871 | 0 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0165143 | 0.0100088 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.094312 | 0.414048 | 0.414048 |
Loa Loa (eye worm) | hypothetical protein | 0.0145871 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145871 | 0 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0165143 | 0.0100088 | 0.5 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.094312 | 0.414048 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145871 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145871 | 0 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0165143 | 0.0100088 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.094312 | 0.414048 | 0.414048 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0165143 | 0.0100088 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0145871 | 0 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.094312 | 0.414048 | 0.447987 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0145871 | 0 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0165143 | 0.0100088 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0165143 | 0.0100088 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.094312 | 0.414048 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.094312 | 0.414048 | 1 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.094312 | 0.414048 | 0.414048 |
Loa Loa (eye worm) | hypothetical protein | 0.0145871 | 0 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.207137 | 1 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0165143 | 0.0100088 | 0.0108292 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.0342 ng ml-1 | Compound was tested in vitro for antimalarial activity against W-2 strain (Plasmodium falciparum) | ChEMBL. | 11689078 |
IC90 (functional) | = 0.32 ng ml-1 | In vitro for antimalarial activity against K-1 strain (Plasmodium falciparum) | ChEMBL. | 11689078 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 11689078 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.