Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Integrase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0057 | 0.1182 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0125 | 0.4375 | 1 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0129 | 0.4545 | 0.5 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0186 | 0.7249 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0057 | 0.1182 | 0.5 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0186 | 0.7249 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.007 | 0.1767 | 0.1767 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.015 | 0.5564 | 0.5564 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.1767 | 0.4038 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0186 | 0.7249 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0 | 0.5 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0186 | 0.7249 | 0.5 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0186 | 0.7249 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0244 | 1 | 1 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0186 | 0.7249 | 0.5 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0186 | 0.7249 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.5564 | 0.5564 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0057 | 0.1182 | 0.5 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0186 | 0.7249 | 0.5 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0186 | 0.7249 | 1 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0186 | 0.7249 | 0.7249 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0102 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0186 | 0.7249 | 0.7249 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.4375 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0 | 0.5 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0186 | 0.7249 | 1 |
Onchocerca volvulus | 0.0186 | 0.7249 | 1 | |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0102 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.3289 | 0.3289 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0102 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.1767 | 0.1767 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0244 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.