Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | folate hydrolase (prostate-specific membrane antigen) 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Candida albicans | similar to transferrin receptor | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Schistosoma japonicum | ko:K01301 glutamate carboxypeptidase II [EC3.4.17.21], putative | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Candida albicans | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0236 | 0.8941 | 0.8595 |
Brugia malayi | phosphoinositide-dependent protein kinase I | 0.01 | 0.2464 | 0.2756 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0163 | 0.5465 | 0.3982 |
Trichomonas vaginalis | AGC family protein kinase | 0.01 | 0.2464 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.01 | 0.2464 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0258 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.01 | 0.2464 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.8941 | 1 |
Brugia malayi | hypothetical protein | 0.0236 | 0.8941 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.4948 | 0.3836 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.5654 | 0.4926 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0236 | 0.8941 | 0.8595 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.2981 | 0.0798 |
Schistosoma mansoni | serine/threonine protein kinase | 0.01 | 0.2464 | 0.8827 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0107 | 0.2792 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.01 | 0.2464 | 0.5 |
Onchocerca volvulus | 0.0048 | 0 | 0.5 | |
Brugia malayi | Protein kinase domain containing protein | 0.01 | 0.2464 | 0.2756 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3 nM | Inhibition of [131I]DCIT from PSMA in human LNCAP cells | ChEMBL. | 19111054 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.